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AB273598

SRT1720 hydrochloride

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(1 Publication)

MW 506 Da, Purity >98%. Selective SIRT1 activator (EC50 = 0.16 μM), 230-fold less potent for SIRT2 and SIRT3. Induce autophagy.
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Chemical Structure - SRT1720 hydrochloride (AB273598)
  • Chemical Structure

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Chemical Structure - SRT1720 hydrochloride (AB273598)

Chemical structure of SRT1720 hydrochloride, 1001645-58-4

Key facts

CAS number

1001645-58-4

Purity

>98%

Form

Solid

form

Molecular weight

506 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>4</sub>ClN<sub>7</sub>OS

PubChem

25232708

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

SRT 1720 Hydrochloride

Biological description

Selective SIRT1 activator (EC50 = 0.16 μM), 230-fold less potent for SIRT2 and SIRT3. Induce autophagy.

Canonical smiles

C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl

InChi

InChI=1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H

InChiKey

DTGRRMPPXCRRIM-UHFFFAOYSA-N

IUPAC Name

N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 81:324 PubMed39080028

2024

Decreased AMPK/SIRT1/PDK4 induced by androgen excess inhibits human endometrial stromal cell decidualization in PCOS.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Hong,Shan Xiao,Lianghui Diao,Ruochun Lian,Cong Chen,Yong Zeng,Su Liu
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