MW 211.2 Da, Purity >99%. Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in vitro and in vivo.
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- Genes and environment : the official journal of the Japanese Environmental Mutagen Society 45:192023Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Takata,Katsuyuki Kiura,Takamasa Nakasuka,Atsuko Hirabae,Sakae Arimoto-KobayashiPubMed 37280663
- Nature communications 14:23532023HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLena Wiedmann,Francesca De Angelis Rigotti,Nuria Vaquero-Siguero,Elisa Donato,Elisa Espinet,Iris Moll,Elisenda Alsina-Sanchis,Hanibal Bohnenberger,Elena Fernandez-Florido,Ronja Mülfarth,Margherita Vacca,Jennifer Gerwing,Lena-Christin Conradi,Philipp Ströbel,Andreas Trumpp,Carolin Mogler,Andreas Fischer,Juan Rodriguez-VitaPubMed 37095087
- BioImpacts : BI 13:51-612023Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSevda Jafari,Saba Heydarian,Raymond Lai,Elnaz Mehdizadeh Aghdam,Ommoleila MolaviPubMed 36816998
- Cell reports 42:1121372023Cationic amphiphilic antihistamines inhibit STAT3 via Ca-dependent lysosomal H efflux.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBin Liu,Ran Chen,Yidan Zhang,Jinrong Huang,Yonglun Luo,Susanne Rosthøj,Chenyang Zhao,Marja JäätteläPubMed 36807142
- Cell reports 41:1118252022Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKathryn S Potts,Rosannah C Cameron,Amina Metidji,Noura Ghazale,LaShanale Wallace,Ana I Leal-Cervantes,Reid Palumbo,Juan Martin Barajas,Varun Gupta,Srinivas Aluri,Kith Pradhan,Jacquelyn A Myers,Mia McKinstry,Xiaoying Bai,Gaurav S Choudhary,Aditi Shastri,Amit Verma,Esther A Obeng,Teresa V BowmanPubMed 36516770
- Frontiers in physiology 13:8560882022CCL5 Suppresses Klotho Expression p-STAT3/DNA Methyltransferase1-Mediated Promoter Hypermethylation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQiFeng Liu,ShaSha Li,LiXia Yu,XiaoYa Yin,Xi Liu,JianMing Ye,GuoYuan LuPubMed 35299661
- Cell reports 38:1103092022Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChris S Mantsounga,Cadence Lee,Jade Neverson,Sheila Sharma,Abigail Healy,Joshua M Berus,Crystal Parry,Nicolle M Ceneri,Francesc López-Giráldez,Hyung J Chun,Qing Lu,Frank Sellke,Gaurav Choudhary,Alan R MorrisonPubMed 35108537
- Frontiers in cell and developmental biology 9:8068502022Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhengru Liu,Mingming Qi,Shan Tian,Qian Yang,Jian Liu,Siwei Wang,Mengyao Ji,Rong Yu,Suqi Zeng,Jinting Li,Yuping Wei,Weiguo DongPubMed 35096833
- Cancer immunology research 10:56-692021B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTaito Miyamoto,Ryusuke Murakami,Junzo Hamanishi,Kenji Tanigaki,Yuko Hosoe,Nathan Mise,Shiro Takamatsu,Yuka Mise,Masayo Ukita,Mana Taki,Koji Yamanoi,Naoki Horikawa,Kaoru Abiko,Ken Yamaguchi,Tsukasa Baba,Noriomi Matsumura,Masaki MandaiPubMed 34799346
- Frontiers in immunology 12:7004312021The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1β.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGeorge A Timmons,Richard G Carroll,James R O'Siorain,Mariana P Cervantes-Silva,Lauren E Fagan,Shannon L Cox,Eva Palsson-McDermott,David K Finlay,Emma E Vincent,Nicholas Jones,Annie M CurtisPubMed 34858390
Key facts
- CAS number
- 19983-44-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 211.2 Da
- Molecular formula
- C8H5NO4S
- PubChem identifier
- 2779853
- Nature
- Synthetic
Target data
Alternative names
1110034C02Rik, ADMIO, APRF, AW109958, Acute-phase response factor, DNA binding protein APRF, FLJ20882, HIES, MGC16063, STAT3_HUMAN, Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 3 (acute phase response factor)
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MW 211.2 Da, Purity >99%. Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in vitro and in vivo.
Key facts
- CAS number
- 19983-44-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 211.2 Da
- Molecular formula
- C8H5NO4S
- PubChem identifier
- 2779853
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 50 mM.
- Biochemical name
- Stattic
- Biological description
Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in vitro and in vivo.
- Canonical SMILES
- C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
- InChI
- InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
- InChIKey
- ZRRGOUHITGRLBA-UHFFFAOYSA-N
- IUPAC name
- 6-nitro-1-benzothiophene 1,1-dioxide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Signal Transducer and Activator of Transcription 3 (STAT3) also called p-stat3 or phospho-STAT3 is a critical transcription factor involved in various cellular processes. The molecular weight of STAT3 is approximately 92 kDa. This protein is expressed broadly across many tissues and cell types. Mechanically upon cytokine or growth factor stimulation STAT3 undergoes phosphorylation resulting in dimerization. This phosphorylated form often referred to as phospho-Stat3 or p-STAT3 translocates to the nucleus where it binds specific DNA sequences to modulate gene transcription.
- Biological function summary
STAT3 is an important player in regulating cell growth and apoptosis. It functions not only as a transcription factor but also as part of a larger protein complex that operates within the cell nucleus to influence gene expression. This multifaceted role enables STAT3 to control the expression of genes related to cell proliferation survival and differentiation impacting various biological processes. These functions highlight its importance in tissue homeostasis and response to extracellular signals.
- Pathways
STAT3 is actively involved in the JAK-STAT signaling pathway a principal route for many cytokines and growth factors and the MAPK pathway. STAT3 interacts with proteins such as JAK kinases which phosphorylate Stat3 and initiate the STAT3 signaling cascade. Additionally it closely associates with the protein Raf1 in the MAPK pathway linking external signals to transcriptional responses. These pathways play a significant role in immune response inflammation and growth signaling.
- Associated diseases and disorders
Researchers have implicated STAT3 in cancer and autoimmune diseases. Persistent activation of STAT3 is often observed in various cancers including breast and lung cancer promoting oncogenesis through altered gene expression. Additionally abnormal STAT3 signaling is associated with autoimmune conditions such as rheumatoid arthritis. The interplay between STAT3 and proteins like IL-6 in these diseases highlights its potential as a therapeutic target for intervention.
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2 product images
Chemical Structure - Stattic, STAT3 inhibitor (ab120952)
2D chemical structure image of ab120952, Stattic, STAT3 inhibitor
Functional Studies - Stattic, STAT3 inhibitor (ab120952)
Anti-STAT3 (phospho Y705) antibody [EP2147Y] ab76315 staining STAT3 (phospho Y705) in MDA-MB-231 cells treated with stattic (ab120952), by ICC/IF. Decrease in STAT3 (phospho Y705) expression correlates with increased concentration of stattic as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120952 (stattic) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-STAT3 (phospho Y705) antibody [EP2147Y] ab76315 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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