JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120952

Stattic, STAT3 inhibitor

4

(1 Review)

|

(31 Publications)

MW 211.2 Da, Purity >99%. Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in vitro and in vivo.
2 Images
Functional Studies - Stattic, STAT3 inhibitor (AB120952)
  • FuncS

Unknown

Functional Studies - Stattic, STAT3 inhibitor (AB120952)

ab76315 staining STAT3 (phospho Y705) in MDA-MB-231 cells treated with stattic (ab120952), by ICC/IF. Decrease in STAT3 (phospho Y705) expression correlates with increased concentration of stattic as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120952 (stattic) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab76315 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Stattic, STAT3 inhibitor (AB120952)
  • Chemical Structure

Lab

Chemical Structure - Stattic, STAT3 inhibitor (AB120952)

2D chemical structure image of ab120952, Stattic, STAT3 inhibitor

Key facts

CAS number

19983-44-9

Purity

>99%

Form

Solid

form

Molecular weight

211.2 Da

Molecular formula

C<sub>8</sub>H<sub>5</sub>NO<sub>4</sub>S

PubChem

2779853

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Stattic

Biological description

Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in vitro and in vivo.

Canonical smiles

C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

InChi

InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChiKey

ZRRGOUHITGRLBA-UHFFFAOYSA-N

IUPAC Name

6-nitro-1-benzothiophene 1,1-dioxide

style
left-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Biochemicals

AB120868

Niclosamide, STAT3 inhibitor

Chemical Structure - Niclosamide, STAT3 inhibitor (AB120868)

  • 0
  • 0
Primary Antibodies

AB68153

Anti-STAT3 antibody [EPR787Y]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Western blot - Anti-STAT3 antibody [EPR787Y] (AB68153)

  • 4
  • 10
Biochemicals

AB120666

Cryptotanshinone, STAT3 inhibitor

Functional Studies - Cryptotanshinone, STAT3 inhibitor (AB120666)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Signal Transducer and Activator of Transcription 3 (STAT3) also called p-stat3 or phospho-STAT3 is a critical transcription factor involved in various cellular processes. The molecular weight of STAT3 is approximately 92 kDa. This protein is expressed broadly across many tissues and cell types. Mechanically upon cytokine or growth factor stimulation STAT3 undergoes phosphorylation resulting in dimerization. This phosphorylated form often referred to as phospho-Stat3 or p-STAT3 translocates to the nucleus where it binds specific DNA sequences to modulate gene transcription.
Biological function summary

STAT3 is an important player in regulating cell growth and apoptosis. It functions not only as a transcription factor but also as part of a larger protein complex that operates within the cell nucleus to influence gene expression. This multifaceted role enables STAT3 to control the expression of genes related to cell proliferation survival and differentiation impacting various biological processes. These functions highlight its importance in tissue homeostasis and response to extracellular signals.

Pathways

STAT3 is actively involved in the JAK-STAT signaling pathway a principal route for many cytokines and growth factors and the MAPK pathway. STAT3 interacts with proteins such as JAK kinases which phosphorylate Stat3 and initiate the STAT3 signaling cascade. Additionally it closely associates with the protein Raf1 in the MAPK pathway linking external signals to transcriptional responses. These pathways play a significant role in immune response inflammation and growth signaling.

Researchers have implicated STAT3 in cancer and autoimmune diseases. Persistent activation of STAT3 is often observed in various cancers including breast and lung cancer promoting oncogenesis through altered gene expression. Additionally abnormal STAT3 signaling is associated with autoimmune conditions such as rheumatoid arthritis. The interplay between STAT3 and proteins like IL-6 in these diseases highlights its potential as a therapeutic target for intervention.
style
left-column
style
left-column

Product protocols

style
left-column

Publications (31)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39273571

2024

Protein Kinase C-Delta Mediates Cell Cycle Reentry and Apoptosis Induced by Amyloid-Beta Peptide in Post-Mitotic Cortical Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Hsuan Wu,A-Ching Chao,Yi-Heng Hsieh,You Lien,Yi-Chun Lin,Ding-I Yang

Immunity 57:1306-1323.e8 PubMed38815582

2024

Intestinal CXCR6 ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Zhou Liang,Ziwen Tang,Changjian Zhu,Feng Li,Shuaijiabin Chen,Xu Han,Ruilin Zheng,Xinrong Hu,Ruoni Lin,Qiaoqiao Pei,Changjun Yin,Ji Wang,Ce Tang,Nan Cao,Jincun Zhao,Rong Wang,Xiaoyan Li,Ning Luo,Qiong Wen,Jianwen Yu,Jianbo Li,Xi Xia,Xunhua Zheng,Xin Wang,Naya Huang,Zhong Zhong,Chengqiang Mo,Peisong Chen,Yating Wang,Jinjin Fan,Yun Guo,Haojie Zhong,Jiaqi Liu,Zhenwei Peng,Haiping Mao,Guo-Ping Shi,Joseph V Bonventre,Wei Chen,Yi Zhou

Genes and environment : the official journal of the Japanese Environmental Mutagen Society 45:19 PubMed37280663

2023

Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Takata,Katsuyuki Kiura,Takamasa Nakasuka,Atsuko Hirabae,Sakae Arimoto-Kobayashi

Nature communications 14:2353 PubMed37095087

2023

HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lena Wiedmann,Francesca De Angelis Rigotti,Nuria Vaquero-Siguero,Elisa Donato,Elisa Espinet,Iris Moll,Elisenda Alsina-Sanchis,Hanibal Bohnenberger,Elena Fernandez-Florido,Ronja Mülfarth,Margherita Vacca,Jennifer Gerwing,Lena-Christin Conradi,Philipp Ströbel,Andreas Trumpp,Carolin Mogler,Andreas Fischer,Juan Rodriguez-Vita

BioImpacts : BI 13:51-61 PubMed36816998

2023

Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Sevda Jafari,Saba Heydarian,Raymond Lai,Elnaz Mehdizadeh Aghdam,Ommoleila Molavi

Cell reports 42:112137 PubMed36807142

2023

Cationic amphiphilic antihistamines inhibit STAT3 via Ca-dependent lysosomal H efflux.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Liu,Ran Chen,Yidan Zhang,Jinrong Huang,Yonglun Luo,Susanne Rosthøj,Chenyang Zhao,Marja Jäättelä

Cell reports 41:111825 PubMed36516770

2022

Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Kathryn S Potts,Rosannah C Cameron,Amina Metidji,Noura Ghazale,LaShanale Wallace,Ana I Leal-Cervantes,Reid Palumbo,Juan Martin Barajas,Varun Gupta,Srinivas Aluri,Kith Pradhan,Jacquelyn A Myers,Mia McKinstry,Xiaoying Bai,Gaurav S Choudhary,Aditi Shastri,Amit Verma,Esther A Obeng,Teresa V Bowman

Frontiers in physiology 13:856088 PubMed35299661

2022

CCL5 Suppresses Klotho Expression p-STAT3/DNA Methyltransferase1-Mediated Promoter Hypermethylation.

Applications

Unspecified application

Species

Unspecified reactive species

QiFeng Liu,ShaSha Li,LiXia Yu,XiaoYa Yin,Xi Liu,JianMing Ye,GuoYuan Lu

Cell reports 38:110309 PubMed35108537

2022

Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A.

Applications

Unspecified application

Species

Unspecified reactive species

Chris S Mantsounga,Cadence Lee,Jade Neverson,Sheila Sharma,Abigail Healy,Joshua M Berus,Crystal Parry,Nicolle M Ceneri,Francesc López-Giráldez,Hyung J Chun,Qing Lu,Frank Sellke,Gaurav Choudhary,Alan R Morrison

Frontiers in cell and developmental biology 9:806850 PubMed35096833

2022

Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengru Liu,Mingming Qi,Shan Tian,Qian Yang,Jian Liu,Siwei Wang,Mengyao Ji,Rong Yu,Suqi Zeng,Jinting Li,Yuping Wei,Weiguo Dong
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com