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AB142174

StemRegenin 1 hydrochloride, AhR antagonist

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(1 Publication)

StemRegenin 1 (SR1) hydrochloride (ab142174) is a cell-permeable, potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 127 nM). Used for hematopoietic differentiation of iPSCs. MW 429.5, Purity >98%.

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Chemical Structure - StemRegenin 1 hydrochloride, AhR antagonist (AB142174)
  • Chemical Structure

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Chemical Structure - StemRegenin 1 hydrochloride, AhR antagonist (AB142174)

2D chemical structure image of ab142174, StemRegenin 1 hydrochloride, AhR antagonist

Key facts

CAS number

1227633-49-9

Purity

>98%

Form

Solid

form

Molecular weight

429.5 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>3</sub>N<sub>5</sub>OS

PubChem

46199207

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM (with warming)

Biochemical name

StemRegenin 1

Biological description

Cell-permeable, potent aryl hydrocarbon receptor antagonist (IC50 = 127 nM). Used for hematopoietic differentiation of iPSCs. Active in vitro and in vivo.

Canonical smiles

CC(C)N1C=NC2=C(N=C(N=C21)C3=CSC4=CC=CC=C43)NCCC5=CC=C(C=C5)O

InChi

InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)

InChiKey

BGFHMYJZJZLMHW-UHFFFAOYSA-N

IUPAC Name

4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1967 StemRegenin 1. 1967-5 is the same size as the 5 mg size of ab142174.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

JACC. Basic to translational science 9:607-627 PubMed38984053

2024

Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Sohel M Julovi,Katie Trinh,Harry Robertson,Cuicui Xu,Nikita Minhas,Seethalakshmi Viswanathan,Ellis Patrick,John D Horowitz,Daniel N Meijles,Natasha M Rogers
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Product promise

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