STF-083010, IRE1alpha endonuclease inhibitor

Key facts

CAS number

307543-71-1

Form

Solid

form

Molecular weight

317.4 Da

Molecular formula

C₁₅H₁₁NO₃S₂

PubChem

6537512

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CID 6537512

Biological description

Selective IRE1α endonuclease inhibitor. Dose dependently inhibits XBP-1 splicing. Shows cancer cell selective cytotoxic and cytostatic antiproliferative effects. Shows antitumor effects in vivo.

Canonical smiles

C1=CC=C2C(=C1)C=CC(=O)C2=CNS(=O)(=O)C3=CC=CS3

Isomeric smiles

C1=CC=C\2C(=C1)C=CC(=O)/C2=C\NS(=O)(=O)C3=CC=CS3

InChi

InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,16H/b13-10-

InChiKey

AUXKGDNZANYAPX-RAXLEYEMSA-N

IUPAC Name

N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]thiophene-2-sulfonamide