MW 317.4 Da. Selective IRE1α endonuclease inhibitor. Dose dependently inhibits XBP-1 splicing. Shows cancer cell selective cytotoxic and cytostatic antiproliferative effects. Shows antitumor effects in vivo. .
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- iScience 25:1040502022Subtilase cytotoxin from Shiga-toxigenic impairs the inflammasome and exacerbates enteropathogenic bacterial infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHiroyasu Tsutsuki,Tianli Zhang,Kinnosuke Yahiro,Katsuhiko Ono,Yukio Fujiwara,Sunao Iyoda,Fan-Yan Wei,Kazuaki Monde,Kazuko Seto,Makoto Ohnishi,Hiroyuki Oshiumi,Takaaki Akaike,Tomohiro SawaPubMed 35345462
- Pharmacology research & perspectives 9:e007912021Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSuoli Cheng,Xueqin Liu,Fan Gong,Xiaoling Ding,Xuebing Zhou,Cuiyun Liu,Fei Zhao,Xiaoliang Li,Jiandang ShiPubMed 34038621
- Biomedical and environmental sciences : BES 31:867-8752019Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao Nuan Luo,Hai Lan Yao,Juan Song,Qin Qin Song,Bing Tian Shi,Dong Xia,Jun HanPubMed 30636656
Key facts
- CAS number
- 307543-71-1
- Form
- Solid
- Molecular weight
- 317.4 Da
- Molecular formula
- C15H11NO3S2
- PubChem identifier
- 6537512
- Nature
- Synthetic
Target data
Recommended products
MW 317.4 Da. Selective IRE1α endonuclease inhibitor. Dose dependently inhibits XBP-1 splicing. Shows cancer cell selective cytotoxic and cytostatic antiproliferative effects. Shows antitumor effects in vivo. .
Key facts
- CAS number
- 307543-71-1
- Form
- Solid
- Molecular weight
- 317.4 Da
- Molecular formula
- C15H11NO3S2
- PubChem identifier
- 6537512
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- CID 6537512
- Biological description
Selective IRE1α endonuclease inhibitor. Dose dependently inhibits XBP-1 splicing. Shows cancer cell selective cytotoxic and cytostatic antiproliferative effects. Shows antitumor effects in vivo.
- Canonical SMILES
- C1=CC=C2C(=C1)C=CC(=O)C2=CNS(=O)(=O)C3=CC=CS3
- Isomeric SMILES
- C1=CC=C\2C(=C1)C=CC(=O)/C2=C\NS(=O)(=O)C3=CC=CS3
- InChI
- InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,16H/b13-10-
- InChIKey
- AUXKGDNZANYAPX-RAXLEYEMSA-N
- IUPAC name
- N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]thiophene-2-sulfonamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - STF-083010, IRE1alpha endonuclease inhibitor (ab146176)
2D chemical structure image of ab146176, STF-083010, IRE1alpha endonuclease inhibitor
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