JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB142155

Streptozocin, Pancreatic beta-cell toxin

Be the first to review this product! Submit a review

|

(10 Publications)

MW 265.22 Da, Purity >95%. Selective pancreatic β-cell toxin. DNA alkylating agent. Diabetagen and anticancer activity in vivo.
1 Images
Chemical Structure - Streptozocin, Pancreatic beta-cell toxin (AB142155)
  • Chemical Structure

Lab

Chemical Structure - Streptozocin, Pancreatic beta-cell toxin (AB142155)

2D chemical structure image of ab142155, Streptozocin, Pancreatic beta-cell toxin

Key facts

CAS number

18883-66-4

Purity

>95%

Form

Solid

form

Source

Stretomyces achromogenes

Molecular weight

265.22 Da

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>5</sub>N<sub>3</sub>O<sub>7</sub>

PubChem

7067772

Nature

Native

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Streptozotocin

Biological description

Selective pancreatic β-cell toxin. DNA alkylating agent. Diabetagen and anticancer activity in vivo.

Canonical smiles

CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O

Isomeric smiles

CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O)N=O

InChi

InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7-/m1/s1

InChiKey

ZSJLQEPLLKMAKR-NYMZXIIRSA-N

IUPAC Name

1-methyl-1-nitroso-3-[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea

style
left-column

Complementary Products

Assay Kits

AB236712

Rat TNF alpha ELISA Kit

Recombinant|SimpleStep

ELISA - Rat TNF alpha ELISA Kit (AB236712)

  • 0
  • 0
Primary Antibodies

AB178846

Anti-Iba1 antibody [EPR16588] - Microglia marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Iba1 antibody [EPR16588] - Microglia marker (AB178846)

  • 5
  • 49
Primary Antibodies

AB13847

Anti-Caspase-3 antibody

KO Validated

Western blot - Anti-Caspase-3 antibody (AB13847)

  • 4
  • 56
Assay Kits

AB118970

Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric)

Biochemical assay - Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric) (AB118970)

  • 5
  • 3
style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1930 Streptozocin. 1930-500 is the same size as the 500 mg size of ab142155.
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (10)

Recent publications for all applications. Explore the full list and refine your search

International journal of medical sciences 19:729-739 PubMed35582427

2022

Dapagliflozin Ameliorates Lipopolysaccharide Related Acute Kidney Injury in Mice with Streptozotocin-induced Diabetes Mellitus.

Applications

Unspecified application

Species

Unspecified reactive species

Po-Jui Chi,Chung-Jen Lee,Yi-Jen Hsieh,Chia-Wen Lu,Bang-Gee Hsu

Saudi journal of biological sciences 29:1210-1220 PubMed35241966

2022

Urolithin A prevents streptozotocin-induced diabetic cardiomyopathy in rats by activating SIRT1.

Applications

Unspecified application

Species

Unspecified reactive species

Gadah Albasher,Saad Alkahtani,Laila Naif Al-Harbi

Molecular medicine reports 25: PubMed35119079

2022

Exenatide exerts a neuroprotective effect against diabetic cognitive impairment in rats by inhibiting apoptosis: Role of the JNK/c‑JUN signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Gengyin Wang,Zongquan Zhao,Bo Ren,Wu Yu,Xudong Zhang,Jiang Liu,Liping Wang,Daowen Si,Meiliu Yang

Pharmaceutical biology 60:25-37 PubMed34870551

2021

Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK.

Applications

Unspecified application

Species

Unspecified reactive species

Jozaa Z ALTamimi,Ghedeir M Alshammari,Nora A AlFaris,Reham I Alagal,Dalal H Aljabryn,Norah A Albekairi,Mahmoud Ahmad Alkhateeb,Mohammed Abdo Yahya

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 71: PubMed33901999

2021

Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

J Z Altamimi,N A Alfaris,G M Alshammari,R I Alagal,D H Aljabryn,H Aldera,M A Alkhateeb,M A Yahya

Saudi journal of biological sciences 28:4300-4310 PubMed34354412

2021

Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2.

Applications

Unspecified application

Species

Unspecified reactive species

Jozaa Z ALTamimi,Nora A AlFaris,Dalal H Aljabryn,Reham I Alagal,Ghedeir M Alshammari,Hussain Aldera,Sultan Alqahtani,Mohammed Abdo Yahya

Pharmaceutics 13: PubMed33670981

2021

6-Gingerol, a Bioactive Compound of Ginger Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats by Regulating the Oxidative Stress and Inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Saleh A Almatroodi,Abdullah M Alnuqaydan,Ali Yousif Babiker,Mashael Abdullah Almogbel,Amjad Ali Khan,Arshad Husain Rahmani

Frontiers in aging neuroscience 12:201 PubMed32792939

2020

Strawberry Leaf Extract Treatment Alleviates Cognitive Impairment by Activating Nrf2/HO-1 Signaling in Rats With Streptozotocin-Induced Diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Li Zhang,Qinghua Ma,Yanling Zhou

JCI insight 4: PubMed31534053

2019

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.

Applications

Unspecified application

Species

Unspecified reactive species

Victor G Puelles,James W van der Wolde,Nicola Wanner,Markus W Scheppach,Luise A Cullen-McEwen,Tillmann Bork,Maja T Lindenmeyer,Lukas Gernhold,Milagros N Wong,Fabian Braun,Clemens D Cohen,Michelle M Kett,Christoph Kuppe,Rafael Kramann,Turgay Saritas,Claudia R van Roeyen,Marcus J Moeller,Leon Tribolet,Richard Rebello,Yu By Sun,Jinhua Li,Gerhard Müller-Newen,Michael D Hughson,Wendy E Hoy,Fermin Person,Thorsten Wiech,Sharon D Ricardo,Peter G Kerr,Kate M Denton,Luc Furic,Tobias B Huber,David J Nikolic-Paterson,John F Bertram

Molecular medicine reports 16:9131-9136 PubMed28990110

2017

Effects of butylphthalide on cognitive decline in diabetic rats.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyan Tian,Jinhua Wang,Yan Wang,Miao Zhang,Yuying Zhou
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com