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MW 390.5 Da, Purity >99%. Selective VEGFR-2 inhibitor (IC50 = 700 nM). Shows antiangiogenic activity. Active in vivo.
Alternative names=AI838772, AW493413, CD309, CD309 antigen, EC 2.7.10.1, FLJ11090, FLK-1, FLK1, mouse, homolog of, Fetal liver kinase 1, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), Ly73, MGC104252, MGC112732, Protein-tyrosine kinase receptor flk-1, RP24-311F12.2, SCAN1, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosine kinase growth factor receptor, Tyrosyl-DNA phosphodiesterase 1, VEGFR, VEGFR-2, VGFR2_HUMAN, Vascular endothelial growth factor receptor 2, soluble VEGFR2
- CAS number
168835-82-3
- Purity
> 99%
- Form
Solid
- Molecular weight
390.5 Da
- Molecular formula
C25H30N2O2
- PubChem identifier
5941539
- Nature
Synthetic
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MW 390.5 Da, Purity >99%. Selective VEGFR-2 inhibitor (IC50 = 700 nM). Shows antiangiogenic activity. Active in vivo.
Alternative names=AI838772, AW493413, CD309, CD309 antigen, EC 2.7.10.1, FLJ11090, FLK-1, FLK1, mouse, homolog of, Fetal liver kinase 1, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), Ly73, MGC104252, MGC112732, Protein-tyrosine kinase receptor flk-1, RP24-311F12.2, SCAN1, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosine kinase growth factor receptor, Tyrosyl-DNA phosphodiesterase 1, VEGFR, VEGFR-2, VGFR2_HUMAN, Vascular endothelial growth factor receptor 2, soluble VEGFR2
Key facts
- CAS number
168835-82-3
- Purity
> 99%
- Form
Solid
- Molecular weight
390.5 Da
- Molecular formula
C25H30N2O2
- PubChem identifier
5941539
- Nature
Synthetic
- Biochemical name
(E)-2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
- Biological description
Selective VEGFR-2 inhibitor (IC50 = 700 nM). Shows antiangiogenic activity. Active in vivo.
- Canonical SMILES
CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2
- Isomeric SMILES
CC(C)C1=CC(=CC(=C1O)C(C)C)/C=C(\C#N)/C(=O)NCCCC2=CC=CC=C2
- InChI
InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
- InChIKey
JANPYFTYAGTSIN-FYJGNVAPSA-N
- IUPAC name
(E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
Notes
It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 1 hour a DMSO solution showed signs of decomposition. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately
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