SU-5402, VEGFR and FGFR inhibitor

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(2 Publications)

MW 296.32 Da, Purity >97%. Potent, selective VEGFR and FGFR inhibitor (IC₅₀ values are 0.02 (VEGFR2), 0.03 (FGFR1), 0.51 (PDGFRβ) and >100 μM (EGFR)). Attenuates integrin β4-induced differentiation of neural stem cells. Shows antitumor effects in vivo. .

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7TM receptor, ACM2_HUMAN, AChR, ASV, AW259666, Acetylcholine receptor, muscarinic, 2, Avian sarcoma virus, BFGFR, Basic fibroblast growth factor receptor 1, C SRC, CA 2, CA-II, CAC, CAH2_HUMAN, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CD 140B, CD140A, CD140a antigen, CD140b antigen, CD309, CD309 antigen, CD331, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, CEK, CHRM 2, CM2, CNR, CNR1_HUMAN, Cannabinoid receptor 1, Car 2, Carbonate dehydratase II, Carbonic anhydrase 2, Carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase C, formerly, Carbonic anhydrase II, Carbonic dehydratase, Central cannabinoid receptor, Cholinergic receptor muscarinic 2, Cholinergic receptor, muscarinic 2, cardiac, Cholinergic receptor, muscarinic 2, isoform a, Cholinergic receptor, muscarinic 2a, D(2) dopamine receptor, D2 dopamine receptor, D2DR, D2R, DRD2_HUMAN, Dopamine D2 receptor, Dopamine receptor D2, EC 2.7.10.1, EC 2.7.10.2, Epididymis secretory protein Li 282, FGFBR, FGFR1/PLAG1 fusion, FGFR1_HUMAN, FLG, FLJ43243, FLK-1, FLK1, mouse, homolog of, FLT, FLT-2, FRT, Fetal liver kinase 1, Flt-1, Fms related tyrosine kinase 1, Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor, Fms-like gene, Fms-like tyrosine kinase 1, Fms-like tyrosine kinase 2, HBGFR, HEL-76, HEL-S-282, HH2, HM 2, HRTFDS, KAL2, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), Ly73, M2 muscarinic receptor, M2-mAChR, MGC120006, MGC120007, Muscarinic M2 receptor, Muscarinic acetylcholine receptor M2, N-SAM, Neuronal CSRC tyrosine specific protein kinase, Neuronal SRC, Neuronal proto-oncogene tyrosine-protein kinase Src, OGD, OTTHUMP00000016838, OTTHUMP00000174476, OTTHUMP00000174477, OTTHUMP00000214579, Oncogene SRC, PDGF Receptor alpha + beta, PDGF-R-alpha, PDGF-R-beta, PDGFR 2, PDGFRA, PDGFRB, Platelet derived growth factor receptor alpha, Platelet derived growth factor receptor beta, Protein-tyrosine kinase receptor flk-1, Proto-oncogene c-Fgr, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, Protooncogene SRC, Protooncogene SRC Rous sarcoma, SRC Oncogene, SRC proto oncogene non receptor tyrosine kinase, SRC_HUMAN, Soluble VEGF receptor 1 14, Soluble VEGFR1 variant 2, Soluble VEGFR1 variant 21, Tyrosine kinase growth factor receptor, Tyrosine kinase pp60c src, Tyrosine protein kinase SRC 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian), VEGFR, VEGFR-1, VEGFR-2, VGFR1_HUMAN, VGFR2_HUMAN, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor vascular permeability factor receptor, Vascular permeability factor receptor, Vascular permeability factor receptor 1, bFGF-R-1, chrm2a, epididymis luminal protein 76, fibroblast growth factor receptor 1, fms-related tyrosine kinase 2, heparin-binding growth factor receptor, hydroxyaryl-protein kinase, p60-Src, p60c-src, pp60c-src, soluble VEGFR2, v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog, v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian