SU 5416 (Semaxanib), VEGFR-2 inhibitor
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(3 Publications)
MW 238.28 Da, Purity >99%. Selective VEGFR-2 inhibitor. Adenine mimetic. Inhibits endothelial cell proliferation. Inhibits angiogenesis and shows antitumor effects in vivo. .
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CD309, CD309 antigen, EC 2.7.10.1, FLK-1, FLK1, mouse, homolog of, FLT, FLT-4, FLT41, FRT, Fetal liver kinase 1, Flt-1, Fms related tyrosine kinase 1, Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor, Fms related tyrosine kinase 4, Fms-like tyrosine kinase 1, Fms-like tyrosine kinase 4, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), LMPH1A, Ly73, PCL, Protein-tyrosine kinase receptor flk-1, Soluble VEGF receptor 1 14, Soluble VEGFR1 variant 2, Soluble VEGFR1 variant 21, Soluble VEGFR3 variant 1, Soluble VEGFR3 variant 2, Soluble VEGFR3 variant 3, Tyrosine kinase growth factor receptor, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Tyrosine-protein kinase receptor FLT4, VEGFR, VEGFR-1, VEGFR-2, VEGFR-3, VGFR1_HUMAN, VGFR2_HUMAN, VGFR3_HUMAN, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 3, Vascular endothelial growth factor receptor 3 precursor, Vascular endothelial growth factor vascular permeability factor receptor, Vascular permeability factor receptor, Vascular permeability factor receptor 1, soluble VEGFR2
- Chemical Structure
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Chemical Structure - SU 5416 (Semaxanib), VEGFR-2 inhibitor (AB145056)
2D chemical structure image of ab145056, SU 5416 (Semaxanib), VEGFR-2 inhibitor
Properties and storage information
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Supplementary information
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Biological function summary
These receptors play roles in modulating vascular permeability endothelial cell proliferation and blood vessel formation. They are part of complexes that include ligands such as various VEGF isoforms. VEGF Receptor 2 is the principal mediator of VEGF-induced endothelial cell responses. VEGF Receptor 1 serves as a decoy receptor to modulate the availability of VEGF for VEGF Receptor 2 whilst VEGF Receptor 3 mainly regulates lymphatic endothelial cell functions.
Pathways
These receptors are central to the VEGF signaling pathway which plays a role in angiogenesis and vasculogenesis. The pathway involves a cascade where VEGF binding leads to receptor dimerization and phosphorylation of intracellular domains activating downstream pathways like the MAPK and PI3K/Akt pathways. These receptors interact with various proteins including growth factors and other signaling molecules to ensure proper vascular function and adaptation.
Publications (3)
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Frontiers in pharmacology 13:968124 PubMed36091747
2022
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Nature communications 10:1442 PubMed30926814
2019
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Unspecified reactive species
PloS one 12:e0180615 PubMed28686688
2017
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Rat
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