JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB144532

Suberoyl bis-hydroxamic acid (SBHA), HDAC inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 204.22 Da, Purity >98%. Potent, non-selective HDAC inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (ab142387). Induces apoptosis. Shows antiproliferative effects (IC50 = 15 μM, HeLa cells).

View Alternative Names

AHO3, BDMR, CDA07, CDLS5, CPBHM, D10Wsu179e, DKFZp686H12203, EC 3.5.1.98, FLJ16239, GON 10, HA6116, HD 2, HD 4, HD 6, HD 8, HD1, HD3, HDAC A, HDAC1_HUMAN, HDAC2_HUMAN, HDAC3_HUMAN, HDAC4_HUMAN, HDAC6_HUMAN, HDAC8_HUMAN, HDACL-1, Histone Deacetylase A, Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 2 (HD2), Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 6, Histone deacetylase 6 (HD6), Histone deacetylase 8, Histone deacetylase like 1, JM 21, KIAA0288, KIAA0901, MRXS6, OTTHUMP00000017046, OTTHUMP00000032398, OTTHUMP00000197663, OTTHUMP00000227077, OTTHUMP00000227078, PPP1R90, Protein phosphatase 1 regulatory subunit 90, RPD 3, RPD3-2, RPD3L1, Reduced potassium dependency yeast homolog like 1, SMAP45, WTS, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, transcriptional regulator homolog RPD3

Key facts

CAS number

38937-66-5

Purity

>98%

Molecular weight

204.22 Da

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

5173

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

n,n'-Dihydroxyoctanediamide

Biological description

Potent, non-selective HDAC inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (ab142387). Induces apoptosis. Shows antiproliferative effects (IC50 = 15 μM, HeLa cells).

Canonical smiles

C(CCCC(=O)NO)CCC(=O)NO

InChi

InChI=1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)

InChiKey

IDQPVOFTURLJPT-UHFFFAOYSA-N

IUPAC Name

N,N'-dihydroxyoctanediamide

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 and HDAC8 are members of the histone deacetylase family involved in removing acetyl groups from histones which leads to chromatin condensation and transcriptional repression. These enzymes have different molecular weights: HDAC1 at 55 kDa HDAC2 at 55 kDa HDAC3 at 49 kDa HDAC4 at 119 kDa HDAC6 at 131 kDa and HDAC8 at 44 kDa. They are widely expressed in various tissues including the brain liver and heart impacting many cellular functions. These enzymes also go by alternate names such as RPD3-like protein for HDAC1.
Biological function summary

These HDACs play important roles in regulating gene expression by forming multi-protein complexes. They interact with other proteins to modulate DNA accessibility influencing transcriptional outcomes. HDACs often associate with transcription factors and co-repressors such as SMRT and N-CoR to stabilize the transcriptional machinery. As a result they impact cell cycle regulation apoptosis and differentiation. These activities highlight their participation in controlling several essential cellular processes.

Pathways

HDACs integrate into key biological pathways such as the MAPK/ERK pathway and the PI3K/AKT pathway. They control cellular responses to external stimuli and help maintain homeostasis. Through these pathways HDACs interact with proteins like p53 a tumor suppressor and RB1 a regulator of cell cycle progression. Their involvement in these pathways emphasizes their essential role in cellular growth and survival linking them to cellular stress responses and oncogenic processes.

HDACs have strong connections to cancer and neurodegenerative diseases. Abnormal HDAC activity contributes to cancer by modulating the expression of oncogenes and tumor suppressor genes with p53 and Myc being key related proteins. In neurodegenerative disorders such as Alzheimer's disease HDAC dysregulation affects gene expression profiles important for neuronal survival with tau protein being a significant associated protein. This connection to diseases reflects the potential of HDACs as therapeutic targets for modulating these pathological conditions.
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB144480

SAHA (Vorinostat), HDAC inhibitor

  • 0
  • 0
Biochemicals

AB142060

Apicidin, HDAC inhibitor

Chemical Structure - Apicidin, HDAC inhibitor (AB142060)

  • 0
  • 0
Primary Antibodies

AB192890

Anti-LC3B antibody [EPR18709] - Autophagosome Marker

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-LC3B antibody [EPR18709] - Autophagosome Marker (AB192890)

  • 5
  • 19
Biochemicals

AB120224

Rapamycin, mTORC1 complex inhibitor

Chemical Structure - Rapamycin, mTORC1 complex inhibitor (AB120224)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com