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MW 481.58 g/mol. Irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 μM to adipocytes. It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion. Impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.
- CAS number
135661-44-8
- Form
Solid
- Molecular weight
481.58 g/mol
- Molecular formula
C22H36NNaO7S
- Nature
Synthetic
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MW 481.58 g/mol. Irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 μM to adipocytes. It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion. Impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.
Key facts
- CAS number
135661-44-8
- Form
Solid
- Molecular weight
481.58 g/mol
- Molecular formula
C22H36NNaO7S
- Nature
Synthetic
- Biological description
Irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 μM to adipocytes. It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion. Impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.
- IUPAC name
2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic acid sodium salt
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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