JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB145240

Swainsonine, lysosomal alpha-mannosidase inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 173.21 Da, Purity >98%. Reversible lysosomal α-mannosidase inhibitor. Apoptotic agent. Induces apoptosis through mitochondrial pathway and caspase activation. Potentiates the effect of paclitaxel (ab120143). Shows tremorgenic and ataxic effects in vivo. Orally active.
1 Images
Chemical Structure - Swainsonine, lysosomal alpha-mannosidase inhibitor (AB145240)
  • Chemical Structure

Lab

Chemical Structure - Swainsonine, lysosomal alpha-mannosidase inhibitor (AB145240)

2D chemical structure image of ab145240, Swainsonine, lysosomal alpha-mannosidase inhibitor

Key facts

CAS number

72741-87-8

Purity

>98%

Form

Solid

form

Molecular weight

173.21 Da

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>5</sub>NO<sub>3</sub>

PubChem

51683

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Soluble in ethanol

Soluble in DMSO

Biochemical name

Swainsonine

Biological description

Reversible lysosomal α-mannosidase inhibitor. Apoptotic agent. Induces apoptosis through mitochondrial pathway and caspase activation. Potentiates the effect of paclitaxel (ab120143). Shows tremorgenic and ataxic effects in vivo. Orally active.

Canonical smiles

C1CC(C2C(C(CN2C1)O)O)O

Isomeric smiles

C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O

InChi

InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1

InChiKey

FXUAIOOAOAVCGD-WCTZXXKLSA-N

IUPAC Name

(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

style
left-column

Complementary Products

Assay Kits

AB234622

Lysosomal Intracellular Activity Assay Kit

Functional Studies - Lysosomal Intracellular Activity Assay Kit (AB234622)

  • 0
  • 0
Primary Antibodies

AB223175

Anti-p26 antibody

Immunocytochemistry/ Immunofluorescence - Anti-p26 antibody (AB223175)

  • 0
  • 0
Assay Kits

AB211113

Lysozyme Activity Assay Kit (Fluorometric)

Functional Studies - Lysozyme Activity Assay Kit (Fluorometric) (AB211113)

  • 0
  • 0
Assay Kits

AB252887

Lysosomal alpha-Glucosidase Activity Assay Kit (Fluorometric)

Enzyme activity assay - Lysosomal alpha-Glucosidase Activity Assay Kit (Fluorometric) (AB252887)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com