T0901317, LXR agonist

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(2 Publications)

MW 481.3 Da, Purity >99%. Potent, non-selective LXR agonist (EC₅₀ = 50 nM). Increases ABCA1 expression associated with cholesterol efflux regulation and HDL metabolism. Increases muscle expression of PPAR-δ. Shows antiobesogenic effects in vivo. .

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AIS, ANDR_HUMAN, AR, AR8, AW107337, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), BAR, BXR, Bile acid receptor, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), FLJ00280, FLJ00318, FLJ16020, FLJ16733, Farnesoid X-activated receptor, Farnesol receptor HRR-1, G-6-Pase, G6PC_HUMAN, G6PT, G6Pase-alpha, GCCR, GCRST, GCR_HUMAN, GR, GSD1, GSD1a, Glucocorticoid receptor, Glucose-6-phosphatase, Glucose-6-phosphatase alpha, Grl1, HRR 1, HUMARA, HYSP1, IMD42, KD, Kennedy disease (KD), LX receptor beta, LXR a, LXR b, LXR beta, Liver X nuclear receptor beta, Liver X receptor alpha, Liver X receptor beta, MGC102720, MGC129539, MGC163350, MGC93613, NER I, NER1, NR1F1, NR1F3, NR1H2_HUMAN, NR1H3_HUMAN, NR1I2_HUMAN, NR2B1, NR3C4, Nuclear orphan receptor LXR beta, Nuclear receptor NER, Nuclear receptor ROR-alpha, Nuclear receptor ROR-gamma, Nuclear receptor RZR-alpha, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 1, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group H member 2, Nuclear receptor subfamily 1 group H member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OR-1, OTTHUMP00000022510, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, Oxysterols receptor LXR-alpha, Oxysterols receptor LXR-beta, PAR, PAR q, PRR, Pregnane X receptor, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor alpha, RAR related orphan receptor gamma, RAR-related orphan receptor A, RAR-related orphan receptor C, RIP 14, RIP15, RLD 1, RORA_HUMAN, RORG_HUMAN, RP23-281C18.19, RXR alpha1, RXR-interacting protein 14, RXRA_HUMAN, RZR GAMMA, RZR-ALPHA, RZRA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid receptor RXR-alpha, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, Retinoid X receptor-interacting protein 14, Retinoid-related orphan receptor-alpha, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SMAX1, SXR, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone nuclear receptor NER, TFM, TOR, Testicular Feminization (TFM), Transcription factor RZR alpha, UNR, Ubiquitously-expressed nuclear receptor, androgen receptor splice variant 4b, fhl2a, g6pc, glucocorticoid nuclear receptor variant 1, glucose-6-phosphatase, catalytic subunit, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), pregnane X nuclear receptor variant 2