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AB120656

Tamoxifen citrate, Estrogen receptor antagonist and partial agonist

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(2 Publications)

MW 563.65 g/mol, Purity >99%. Competitive estrogen receptor antagonist and partial agonist. Inhibits estrogen dependent gene transcription and tumor growth. Additionally decreases cardiac infarction and inhibits Kir2.1, Kir2.2 and Kir2.3 potassium channels (IC50 values are 0.93, 0.87 and 0.31 μM, respectively).
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Chemical Structure - Tamoxifen citrate, Estrogen receptor antagonist and partial agonist (AB120656)
  • Chemical Structure

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Chemical Structure - Tamoxifen citrate, Estrogen receptor antagonist and partial agonist (AB120656)

2D chemical structure image of ab120656, Tamoxifen citrate, Estrogen receptor antagonist and partial agonist

Key facts

CAS number

54965-24-1

Purity

>99%

Form

Solid

form

Molecular weight

563.65 g/mol

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>2</sub><sub>9</sub>NO.C<sub>6</sub>H<sub>8</sub>O<sub>7</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 5 mM

Biological description

Competitive estrogen receptor antagonist and partial agonist. Inhibits estrogen dependent gene transcription and tumor growth. Additionally decreases cardiac infarction and inhibits Kir2.1, Kir2.2 and Kir2.3 potassium channels (IC50 values are 0.93, 0.87 and 0.31 μM, respectively).

IUPAC Name

(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer gene therapy 31:69-81 PubMed37935981

2023

Tafazzin mediates tamoxifen resistance by regulating cellular phospholipid composition in ER-positive breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xuan Li,Yuan Zhang,Tengjiang Zhang,Luyang Zhao,Christopher G Lin,Haitian Hu,Hanqiu Zheng

Cell stem cell 30:86-95.e4 PubMed36563695

2022

A deep learning platform to assess drug proarrhythmia risk.

Applications

Unspecified application

Species

Unspecified reactive species

Ricardo Serrano,Dries A M Feyen,Arne A N Bruyneel,Anna P Hnatiuk,Michelle M Vu,Prashila L Amatya,Isaac Perea-Gil,Maricela Prado,Timon Seeger,Joseph C Wu,Ioannis Karakikes,Mark Mercola
View all publications
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