Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion
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MW 276.3 Da, Purity >95%. Cytotoxic to cancer cells, inhibits cell migration and invasion. Shows anti-inflammatory, Anticancer, immunosuppressive and anticoagulant agent. Active in vivo and in vitro.
View Alternative Names
70Z-SHP, AI413597, AW045860, CE-2, CES2, CES2A1, Carboxylesterase 2, Carboxylesterase 2 (intestine, liver), Cocaine esterase, DDPAC, EC 3.1.1.1, EC 3.1.3.48, EST2_HUMAN, FLJ31424, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, HCP, HCPH, HPTP1C, Hematopoietic cell phosphatase, Hematopoietic cell protein-tyrosine phosphatase, ICE, Iintestinal carboxylesterase liver carboxylesterase 2, Intestinal carboxylesterase; liver carboxylesterase-2, MAPT, MAPTL, MGC134287, MGC138549, MGC156663, MSTD, MTBT1, MTBT2, Methylumbelliferyl acetate deacetylase 2, Microtubule associated protein tau isoform 4, Microtubule-associated protein tau, Mtapt, Neurofibrillary tangle protein, PCE-2, PHF-tau, PPND, PPP1R103, PTN6_HUMAN, PTP-1C, Paired helical filament-tau, Protein phosphatase 1, regulatory subunit 103, Protein tyrosine phosphatase non receptor type 6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, Ptpn6, RNPTAU, SH-PTP1, SHP 1L, TAU_HUMAN, Tauopathy and respiratory failure, Tauopathy and respiratory failure, included, Tyrosine-protein phosphatase non-receptor type 6, hCE-2, pTau
- Chemical Structure
Lab
Chemical Structure - Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion (AB142664)
2D chemical structure image of ab142664, Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion
Properties and storage information
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Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Tau maintains microtubule stability which is essential for neuronal transport and function. Tau does not often form complexes but can be hyperphosphorylated affecting its function. SHP-1 is a cytoplasmic tyrosine phosphatase that regulates signaling pathways in immune cells often being part of larger signaling complexes. CES2 is involved in hydrolyzing ester and amide bonds critical for the detoxification of various substances and metabolism of some prodrugs.
Pathways
Tau closely links to the MAPK signaling pathway influencing neuronal growth and differentiation. It interacts with proteins like tubulin in microtubules. SHP-1 is an important regulator in the JAK/STAT signaling pathway modulating cytokine signaling in immune responses. It interacts with upstream kinases and downstream proteins like STAT. CES2 is integral to the xenobiotic metabolism mechanism playing a part in drug detoxification involving the cytochrome P450 enzymes.
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