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MW 415.5 Da, Purity >95%. Broad spectrum inhibitor of TACE (TNF-α convertase/ADAM17/α-secretase), MMPs and other ADAMs. Blocks phorbol-12-myristate-13-acetate-induced (PMA) shedding of cell surface proteins such as TGF-α and β-amyloid precursor protein (IC50 = 10 μM). Inhibits TNF-α release.

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Publications

Key facts

CAS number

689284-12-6

Purity

> 95%

Form

Solid

Molecular weight

415.5 Da

Molecular formula

C19H37N5O5

PubChem identifier

10093303

Nature

Synthetic

Recommended products

MW 415.5 Da, Purity >95%. Broad spectrum inhibitor of TACE (TNF-α convertase/ADAM17/α-secretase), MMPs and other ADAMs. Blocks phorbol-12-myristate-13-acetate-induced (PMA) shedding of cell surface proteins such as TGF-α and β-amyloid precursor protein (IC50 = 10 μM). Inhibits TNF-α release.

Key facts

Purity

> 95%

PubChem identifier

10093303

Solubility

Soluble in water to 50 mM.

Biochemical name

N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide

Biological description

Broad spectrum inhibitor of TACE (TNF-α convertase/ADAM17/α-secretase), MMPs and other ADAMs. Blocks phorbol-12-myristate-13-acetate-induced (PMA) shedding of cell surface proteins such as TGF-α and β-amyloid precursor protein (IC50 = 10 μM). Inhibits TNF-α release.

Canonical SMILES

CC(C)CC(CC(=O)NO)C(=O)NC(C(=O)NC(C)C(=O)NCCN)C(C)(C)C

Isomeric SMILES

C[C@@H](C(=O)NCCN)NC(=O)[C@H](C(C)(C)C)NC(=O)C(CC(C)C)CC(=O)NO

InChI

InChI=1S/C19H37N5O5/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25)/t12-,13?,15+/m0/s1

InChIKey

LMIQCBIEAHJAMZ-RMTCENKZSA-N

IUPAC name

N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2069 TAPI-2. 2069-1 is the same size as the 1 mg size of ab142219.

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