tBuBHQ (BHQ), Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor
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MW 222.32 Da, Purity >99%. Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
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ACLS, AI838772, AIS, ANDR_HUMAN, AR, AR8, ARO, ARO1, AW493413, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Aromatase, Atherosclerosis, susceptibility to, included, BXR, CCE1, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen synthase, Estrogen synthetase, Estrogen-related receptor alpha, Estrra, FLJ00280, FLJ00318, FLJ11090, FLJ16020, FLJ16733, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HDL cholesterol, augmented response of, to hormone replacement, included, HUMARA, HYSP1, IMD42, KD, Kennedy disease (KD), MGC102720, MGC104252, MGC104309, MGC112732, MGC119570, MGC119571, MGC119572, MGC119573, MGC129539, Microsomal monooxygenase, Myocardial infarction, susceptibility to, included, NR1B1, NR1F3, NR1I2_HUMAN, NR2B1, NR3A1, NR3A2, NR3B1, NR3C4, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000022510, OTTHUMP00000162543, OTTHUMP00000198350, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, P 450AROM, PAP A, PAPB, PAR, PAR q, PPD IV, PRR, Pregnane X receptor, RAR, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-alpha, RAR-related orphan receptor C, RARA_HUMAN, RARalpha1, RNESTROR, RORG_HUMAN, RP11-10M8.1, RP24-311F12.2, RXR alpha1, RXRA_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor RXR-alpha, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SCAN1, SMAX1, STRPC4, SXR, Short transient receptor potential channel 4, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TOR, TRP 4, TRPC 4, TRPC4 protein, TRPC4_HUMAN, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transient receptor potential 4, Transient receptor potential cation channel subfamily C member 4, Trp-related protein 4, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Zinc finger protein GLI 3, androgen receptor splice variant 4b, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, hTrp-4, pregnane X nuclear receptor variant 2, transient receptor potential cation channel subfamily C, transient receptor potential channel 4
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Chemical Structure - tBuBHQ (BHQ), Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor (AB120276)
2D chemical structure image of ab120276, tBuBHQ (BHQ), Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins participate in essential signaling pathways and maintain physiological balance. ER and AR influence cell proliferation and differentiation in various tissues including cancerous cells by modulating gene networks. RARα and RXRA act together to affect processes like embryonic development and immune regulation. TDP1 primarily repairs damaged DNA while ROR gamma expressed in immune cells modulates inflammation and autoimmunity. The collective action of these proteins supports cellular processes including hormonal synthesis and calcium homeostasis with TRPC4 being integral for calcium signaling in cells.
Pathways
These targets are embedded in key biological pathways. ER and AR are critical components of the steroid hormone signaling pathway impacting gene regulatory networks through interaction with other signaling proteins. RARα with RXRA contributes to the retinoic acid signaling pathway important for regulating gene expression during development. Aromatase activity directly links to steroid biosynthesis affecting hormone-driven pathways. BHQ a compound that acts on calcium ATPase influences intracellular calcium levels interacting with endoplasmic reticulum components.
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Publications (1)
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Biomaterials 259:120283 PubMed32827796
2020
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