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AB120276

tBuBHQ (BHQ), Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor

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(1 Publication)

MW 222.32 Da, Purity >99%. Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.

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ACLS, AI838772, AIS, ANDR_HUMAN, AR, AR8, ARO, ARO1, AW493413, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Aromatase, Atherosclerosis, susceptibility to, included, BXR, CCE1, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), DHTR, DKFZp686N23123, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen synthase, Estrogen synthetase, Estrogen-related receptor alpha, Estrra, FLJ00280, FLJ00318, FLJ11090, FLJ16020, FLJ16733, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HDL cholesterol, augmented response of, to hormone replacement, included, HUMARA, HYSP1, IMD42, KD, Kennedy disease (KD), MGC102720, MGC104252, MGC104309, MGC112732, MGC119570, MGC119571, MGC119572, MGC119573, MGC129539, Microsomal monooxygenase, Myocardial infarction, susceptibility to, included, NR1B1, NR1F3, NR1I2_HUMAN, NR2B1, NR3A1, NR3A2, NR3B1, NR3C4, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, ONR 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000022510, OTTHUMP00000162543, OTTHUMP00000198350, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, P 450AROM, PAP A, PAPB, PAR, PAR q, PPD IV, PRR, Pregnane X receptor, RAR, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-alpha, RAR-related orphan receptor C, RARA_HUMAN, RARalpha1, RNESTROR, RORG_HUMAN, RP11-10M8.1, RP24-311F12.2, RXR alpha1, RXRA_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor RXR-alpha, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SCAN1, SMAX1, STRPC4, SXR, Short transient receptor potential channel 4, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, TFM, TOR, TRP 4, TRPC 4, TRPC4 protein, TRPC4_HUMAN, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transient receptor potential 4, Transient receptor potential cation channel subfamily C member 4, Trp-related protein 4, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Zinc finger protein GLI 3, androgen receptor splice variant 4b, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, hTrp-4, pregnane X nuclear receptor variant 2, transient receptor potential cation channel subfamily C, transient receptor potential channel 4

1 Images
Chemical Structure - tBuBHQ (BHQ), Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor (AB120276)
  • Chemical Structure

Lab

Chemical Structure - tBuBHQ (BHQ), Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor (AB120276)

2D chemical structure image of ab120276, tBuBHQ (BHQ), Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor

Key facts

CAS number

88-58-4

Purity

>99%

Form

Solid

form

Molecular weight

222.32 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>2</sub><sub>2</sub>O<sub>2</sub>

PubChem

2374

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

2,5-Di-tert-butylhydroquinone

Biological description

Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor

Canonical smiles

CC(C)(C)C1=CC(=C(C=C1O)C(C)(C)C)O

InChi

InChI=1S/C14H22O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8,15-16H,1-6H3

InChiKey

JZODKRWQWUWGCD-UHFFFAOYSA-N

IUPAC Name

2,5-ditert-butylbenzene-1,4-diol

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor also known as ER is a group of proteins with a mass around 66 kDa mainly expressed in reproductive tissues like the ovary uterus and also in breast tissue. Mechanically ER binds estrogen hormones acting as a transcription factor to regulate gene expression. Androgen Receptor (AR) with a mass of approximately 110 kDa shares similar functionality in its response to androgens being key in male reproductive tissues. Aromatase plays a pivotal role by converting androgens into estrogens influencing the action of both ER and AR. Retinoic Acid Receptor alpha (RARα) which forms complexes with Retinoid X Receptor alpha (RXRA) responds to retinoic acids to regulate gene expression. Other important targets include TRPC4 a channel protein involved in calcium transport and PXR which mediates the body's response to xenobiotics.
Biological function summary

These proteins participate in essential signaling pathways and maintain physiological balance. ER and AR influence cell proliferation and differentiation in various tissues including cancerous cells by modulating gene networks. RARα and RXRA act together to affect processes like embryonic development and immune regulation. TDP1 primarily repairs damaged DNA while ROR gamma expressed in immune cells modulates inflammation and autoimmunity. The collective action of these proteins supports cellular processes including hormonal synthesis and calcium homeostasis with TRPC4 being integral for calcium signaling in cells.

Pathways

These targets are embedded in key biological pathways. ER and AR are critical components of the steroid hormone signaling pathway impacting gene regulatory networks through interaction with other signaling proteins. RARα with RXRA contributes to the retinoic acid signaling pathway important for regulating gene expression during development. Aromatase activity directly links to steroid biosynthesis affecting hormone-driven pathways. BHQ a compound that acts on calcium ATPase influences intracellular calcium levels interacting with endoplasmic reticulum components.

These proteins show significant implications. ER and AR are heavily implicated in cancers such as breast and prostate cancer respectively making them targets for cancer therapy. Aromatase is important in estrogen-related disorders like aromatase excess syndrome. ROR gamma has links to autoimmune diseases with its role in immune cell differentiation being critical. By modulating these proteins and their pathways therapeutic interventions aim to manage diseases by targeting specific molecular mechanisms involved.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biomaterials 259:120283 PubMed32827796

2020

Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel.

Applications

Unspecified application

Species

Unspecified reactive species

Kapish Gupta,Inn Chuan Ng,Gowri Manohari Balachander,Binh P Nguyen,Lisa Tucker-Kellogg,Boon Chuan Low,Hanry Yu
View all publications

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