Skip to main content

MW 434 Da, Purity >98%. Potent, selective orexin-2 receptor antagonist (IC50 = 40 nM). Neurological and insomnia agent. Active in vitro and in vivo.

Be the first to review this product! Submit a review

Images

Chemical Structure - TCS OX2 29, Orexin-2 receptor antagonist (AB141316), expandable thumbnail

Key facts

CAS number
1610882-30-8
Purity
> 98%
Form
Solid
Molecular weight
434 Da
Molecular formula
C23H32ClN3O3
PubChem identifier
53302033
Nature
Synthetic

Target data

Recommended products

MW 434 Da, Purity >98%. Potent, selective orexin-2 receptor antagonist (IC50 = 40 nM). Neurological and insomnia agent. Active in vitro and in vivo.

Key facts

Purity
> 98%
PubChem identifier
53302033
Solubility

Soluble in water to 100 mM.

Soluble in DMSO to 10mM.

Biochemical name
(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride
Biological description

Potent, selective orexin-2 receptor antagonist (IC50 = 40 nM). Neurological and insomnia agent. Active in vitro and in vivo.

Canonical SMILES
CC(C)(C)C(C(=O)N1CCC2=CC(=C(C=C2C1)OC)OC)NCC3=CC=NC=C3.Cl
Isomeric SMILES
CC(C)(C)[C@@H](C(=O)N1CCC2=CC(=C(C=C2C1)OC)OC)NCC3=CC=NC=C3.Cl
InChI
InChI=1S/C23H31N3O3.ClH/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26;/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3;1H/t21-;/m1./s1
InChIKey
NHKNHFJTMINMBP-ZMBIFBSDSA-N
IUPAC name
(2S)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(pyridin-4-ylmethylamino)butan-1-one;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - TCS OX2 29, Orexin-2 receptor antagonist (ab141316), expandable thumbnail

    Chemical Structure - TCS OX2 29, Orexin-2 receptor antagonist (ab141316)

    2D chemical structure image of ab141316, TCS OX2 29, Orexin-2 receptor antagonist

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com