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AB141316

TCS OX2 29, Orexin-2 receptor antagonist

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MW 434 Da, Purity >98%. Potent, selective orexin-2 receptor antagonist (IC50 = 40 nM). Neurological and insomnia agent. Active in vitro and in vivo.
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Chemical Structure - TCS OX2 29, Orexin-2 receptor antagonist (AB141316)
  • Chemical Structure

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Chemical Structure - TCS OX2 29, Orexin-2 receptor antagonist (AB141316)

2D chemical structure image of ab141316, TCS OX2 29, Orexin-2 receptor antagonist

Key facts

CAS number

1610882-30-8

Purity

>98%

Form

Solid

form

Molecular weight

434 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>3</sub><sub>2</sub>ClN<sub>3</sub>O<sub>3</sub>

PubChem

53302033

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 10mM

Biochemical name

(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride

Biological description

Potent, selective orexin-2 receptor antagonist (IC50 = 40 nM). Neurological and insomnia agent. Active in vitro and in vivo.

Canonical smiles

CC(C)(C)C(C(=O)N1CCC2=CC(=C(C=C2C1)OC)OC)NCC3=CC=NC=C3.Cl

Isomeric smiles

CC(C)(C)[C@@H](C(=O)N1CCC2=CC(=C(C=C2C1)OC)OC)NCC3=CC=NC=C3.Cl

InChi

InChI=1S/C23H31N3O3.ClH/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26;/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3;1H/t21-;/m1./s1

InChiKey

NHKNHFJTMINMBP-ZMBIFBSDSA-N

IUPAC Name

(2S)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(pyridin-4-ylmethylamino)butan-1-one;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Biochemicals

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Biochemicals

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Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

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