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AB120831

Telmisartan, angiotensin II (AT1) antagonist

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(1 Publication)

MW 514.63 g/mol, Purity >99%. Selective AT1 receptor antagonist (Ki = 3.7 nM). Partial PPAR-γ agonist.
2 Images
Functional Studies - Telmisartan, angiotensin II (AT1) antagonist (AB120831)
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Functional Studies - Telmisartan, angiotensin II (AT1) antagonist (AB120831)

ab8934 staining PPARα in serum starved HepG2 cells treated with telmisartan (ab120831), by ICC/IF. Increase in PPARα expression correlates with increased concentration of telmisartan, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120831 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab8934 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Telmisartan, angiotensin II (AT1) antagonist (AB120831)
  • Chemical Structure

Lab

Chemical Structure - Telmisartan, angiotensin II (AT1) antagonist (AB120831)

2D chemical structure image of ab120831, Telmisartan, angiotensin II (AT1) antagonist

Key facts

CAS number

144701-48-4

Purity

>99%

Form

Solid

form

Molecular weight

514.63 g/mol

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biological description

Selective AT1 receptor antagonist (Ki = 3.7 nM) . Partial PPAR-γ agonist.

IUPAC Name

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

ACS omega 6:11756-11761 PubMed34056329

2021

Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX-9.

Applications

Unspecified application

Species

Unspecified reactive species

Xiuying Zhang,Yanfeng Dong,Hanyu Dong,Yanhui Cui,Qing Du,Xiaoli Wang,Lanlan Li,Hongju Zhang
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