MW 514.63 g/mol, Purity >99%.
Selective AT1 receptor antagonist (Ki = 3.7 nM) . Partial PPAR-γ agonist.
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- ACS omega 6:11756-117612021Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX-9.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiuying Zhang,Yanfeng Dong,Hanyu Dong,Yanhui Cui,Qing Du,Xiaoli Wang,Lanlan Li,Hongju ZhangPubMed 34056329
Key facts
- CAS number
- 144701-48-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 514.63 g/mol
- Nature
- Synthetic
Recommended products
MW 514.63 g/mol, Purity >99%.
Selective AT1 receptor antagonist (Ki = 3.7 nM) . Partial PPAR-γ agonist.
Key facts
- CAS number
- 144701-48-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 514.63 g/mol
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 10 mM.
- Biological description
Selective AT1 receptor antagonist (Ki = 3.7 nM) . Partial PPAR-γ agonist.
- IUPAC name
- 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Telmisartan, angiotensin II (AT1) antagonist (ab120831)
2D chemical structure image of ab120831, Telmisartan, angiotensin II (AT1) antagonist
Functional Studies - Telmisartan, angiotensin II (AT1) antagonist (ab120831)
ab8934 staining PPARα in serum starved HepG2 cells treated with telmisartan (ab120831), by ICC/IF. Increase in PPARα expression correlates with increased concentration of telmisartan, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120831 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab8934 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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