MW 194.15 Da, Purity >99%. DNA alkylating/methylating chemotherapeutic agent. Inhibits DNA replication. Anti-cancer and apoptotic activity in vitro and in vivo. Crosses the blood-brain barrier.
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- Bioengineered 13:14125-141372022SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJie Yu,Lin Han,Feng Yang,Mingliang Zhao,Hong Zhou,Linwang HuPubMed 35730472
Key facts
- CAS number
- 85622-93-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 194.15 Da
- Molecular formula
- C6H6N6O2
- PubChem identifier
- 5394
- Nature
- Synthetic
Target data
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MW 194.15 Da, Purity >99%. DNA alkylating/methylating chemotherapeutic agent. Inhibits DNA replication. Anti-cancer and apoptotic activity in vitro and in vivo. Crosses the blood-brain barrier.
Key facts
- CAS number
- 85622-93-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 194.15 Da
- Molecular formula
- C6H6N6O2
- PubChem identifier
- 5394
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Temozolomide
- Biological description
DNA alkylating/methylating chemotherapeutic agent. Inhibits DNA replication. Anti-cancer and apoptotic activity in vitro and in vivo. Crosses the blood-brain barrier.
- Canonical SMILES
- CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
- InChI
- InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
- InChIKey
- BPEGJWRSRHCHSN-UHFFFAOYSA-N
- IUPAC name
- 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - Temozolomide, DNA alkylating/methylating chemotherapeutic agent (ab141055)
2D chemical structure image of ab141055, Temozolomide, DNA alkylating/methylating chemotherapeutic agent
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