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AB141055

Temozolomide, DNA alkylating/methylating chemotherapeutic agent

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(3 Publications)

MW 194.15 Da, Purity >99%. DNA alkylating/methylating chemotherapeutic agent. Inhibits DNA replication. Anti-cancer and apoptotic activity in vitro and in vivo. Crosses the blood-brain barrier.
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Chemical Structure - Temozolomide, DNA alkylating/methylating chemotherapeutic agent (AB141055)
  • Chemical Structure

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Chemical Structure - Temozolomide, DNA alkylating/methylating chemotherapeutic agent (AB141055)

2D chemical structure image of ab141055, Temozolomide, DNA alkylating/methylating chemotherapeutic agent

Key facts

CAS number

85622-93-1

Purity

>99%

Form

Solid

form

Molecular weight

194.15 Da

Molecular formula

C<sub>6</sub>H<sub>6</sub>N<sub>6</sub>O<sub>2</sub>

PubChem

5394

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Temozolomide

Biological description

DNA alkylating/methylating chemotherapeutic agent. Inhibits DNA replication. Anti-cancer and apoptotic activity in vitro and in vivo. Crosses the blood-brain barrier.

Canonical smiles

CN1C(=O)N2C=NC(=C2N=N1)C(=O)N

InChi

InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChiKey

BPEGJWRSRHCHSN-UHFFFAOYSA-N

IUPAC Name

3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

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Primary Antibodies

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Biochemicals

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Primary Antibodies

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20ul selling size|RabMAb|Recombinant|KO Validated

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 29:127 PubMed39807099

2025

Adiponectin facilitates the cell cycle, inhibits cell apoptosis and induces temozolomide resistance in glioblastoma via the Akt/mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Sun,Fude Liu,Kang Huo,Jianyi Wang,Yawen Cheng,Suhang Shang,Wenlong Ma,Jia Yu,Jianfeng Han

Journal of neurochemistry 168:205-223 PubMed38225203

2024

Molecular prognostic of nine parthanatos death-related genes in glioma, particularly in COL8A1 identification.

Applications

Unspecified application

Species

Unspecified reactive species

Shuangshi Fan,Hao Li,Kun Liu

Bioengineered 13:14125-14137 PubMed35730472

2022

SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Yu,Lin Han,Feng Yang,Mingliang Zhao,Hong Zhou,Linwang Hu
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