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AB235551

Teneligliptin, DPP-4 inhibitor

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(1 Publication)

MW 426.6 Da, Purity >98%. Potent, long-lasting DPP-4 (dipeptidylpeptidase-4) inhibitor. Competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro (IC50 = ~ 1 nM). Attenuates lipogenesis in the liver by activating AMPK and downregulating the expression of genes involved in lipogenesis. Improves metabolic abnormalities in a mouse model of postmenopausal obesity.

View Alternative Names

ADA-binding protein, ADABP, ADCP-2, Adenosine deaminase complexing protein 2, CD 26, CD26 antigen, CD26 antigen 3, DPP IV, DPP IV estoenzyme, DPP4_HUMAN, Dipeptidyl peptidase 4, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase, intestinal, Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), Intestinal dipeptidyl peptidase, T-cell activation antigen CD26, TP 103

Key facts

CAS number

760937-92-6

Purity

>98%

Form

Solid

form

Molecular weight

426.6 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>3</sub><sub>0</sub>N<sub>6</sub>OS

PubChem

11949652

Nature

Synthetic

Solubility

Soluble in water to 159.01 mM

Soluble in DMSO to 159.01 mM

Soluble in ethanol to 27.03 mM

Biochemical name

Teneligliptin

Biological description

Potent, long-lasting DPP-4 (dipeptidylpeptidase-4) inhibitor. Competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro (IC50 = ~ 1 nM). Attenuates lipogenesis in the liver by activating AMPK and downregulating the expression of genes involved in lipogenesis. Improves metabolic abnormalities in a mouse model of postmenopausal obesity.

Canonical smiles

CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5

Isomeric smiles

CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5

InChi

InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1

InChiKey

WGRQANOPCQRCME-PMACEKPBSA-N

IUPAC Name

[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B1932 Teneligliptin. B1932-50 is the same size as the 50 mg size of ab235551.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dipeptidyl peptidase 4 also known as DPP4 or CD26 functions as a serine exopeptidase. This enzyme is involved in cleaving dipeptides from the N-terminus of polypeptides. DPP4 with a mass of approximately 110 kDa is expressed in various tissues such as the liver intestines kidney and lymphocytes. It exists in both a membrane-bound form and a soluble form in blood plasma.
Biological function summary

DPP4 plays a significant role in glucose metabolism and immune function. The enzyme interacts with members of the immune system and regulates proteins such as chemokines growth factors and neuropeptides. DPP4 acts independently and is not known to be part of a larger complex. It modulates biological processes by inactivating peptide hormones and signaling molecules which impacts glucose homeostasis and immune responses.

Pathways

DPP4 impacts the incretin signaling pathway and the immune response pathway. Incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are substrates of DPP4 and play important roles in glucose metabolism. DPP4 also interacts with proteins such as adenosine deaminase (ADA) which impacts T-cell function and immune regulation. The regulation of these pathways by DPP4 influences metabolic and immune health.

DPP4 involvement is relevant in type 2 diabetes and immunological disorders. In type 2 diabetes DPP4 inhibitors modulate the incretin hormones improving glycemic control. Proteins like GLP-1 are affected by DPP4 activity connecting it to diabetes management. In autoimmune diseases altered DPP4 expression can impact immune cell functions influencing conditions such as rheumatoid arthritis. Through its effects on ADA and associated pathways DPP4 can influence both metabolic and immune-related disorders.
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Diabetes, metabolic syndrome and obesity : targets 12:2289-2302 PubMed31807042

2019

Essential Role Of High Glucose-Induced Overexpression Of PKCβ And PKCδ In GLP-1 Resistance In Rodent Cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xietian Pan,Jiangwei Chen,Tingting Wang,Mingming Zhang,Haichang Wang,Haokao Gao
View all publications
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Complementary Products

Assay Kits

AB204722

Dipeptidyl peptidase IV (DPP4) Activity Assay Kit (Fluorometric)

Functional Studies - Dipeptidyl peptidase IV (DPP4) Activity Assay Kit (Fluorometric) (AB204722)

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Biochemicals

AB142101

Sitagliptin Phosphate Monohydrate

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Primary Antibodies

AB215711

Anti-DPP4 antibody [EPR20819]

RabMAb|Recombinant

Western blot - Anti-DPP4 antibody [EPR20819] (AB215711)

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Assay Kits

AB252365

Human DPP4 (CD26) ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human DPP4 (CD26) ELISA Kit (AB252365)

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