MW 2295.8 Da, Purity >95%. Tertiapin Q, blocker of inward-rectifier r K+ channels. Achieve your results faster with highly validated, pure and trusted compounds.
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8 Publications for All applications
- The Journal of neuroscience : the official journal of the Society for Neuroscience 41:7086-71022021G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSouhail Djebari,Guillermo Iborra-Lázaro,Sara Temprano-Carazo,Irene Sánchez-Rodríguez,Mauricio O Nava-Mesa,Alejandro Múnera,Agnès Gruart,José M Delgado-García,Lydia Jiménez-Díaz,Juan D Navarro-LópezPubMed 34261700
- Biomedicine & pharmacotherapy = Biomedecine & phar 101:362-3702018GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYian Huang et. al.PubMed 29499411
- Nature communications 8:18622017Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichael H Berry et. al.PubMed 29192252
- Frontiers in pharmacology 7:452016Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBruno Bragança et. al.PubMed 27014060
- PloS one 10:e01403692015Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlberto Montalbano et. al.PubMed 26460748
- Hypertension (Dallas, Tex. : 1979) 63:783-92014Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeena Murthy et. al.PubMed 24420545
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33:18951-652013Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBruno Vilar,Jérôme Busserolles,Bing Ling,Sophie Laffray,Lauriane Ulmann,Fanny Malhaire,Eric Chapuy,Youssef Aissouni,Monique Etienne,Emmanuel Bourinet,Francine Acher,Jean-Philippe Pin,Alain Eschalier,Cyril GoudetPubMed 24285900
- Journal of hypertension 30:1827-332012Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeena Murthy,Elena A B Azizan,Morris J Brown,Kevin M O'ShaughnessyPubMed 22743686
Key facts
- CAS number
- 252198-49-5
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 2295.8 Da
- Molecular formula
- C100H163N31O23S4
- PubChem identifier
- 92131436
- Nature
- Synthetic
Recommended products
MW 2295.8 Da, Purity >95%. Tertiapin Q, blocker of inward-rectifier r K+ channels. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 252198-49-5
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 2295.8 Da
- Molecular formula
- C100H163N31O23S4
- PubChem identifier
- 92131436
- Nature
- Synthetic
- Solubility
Soluble in water.
- Biochemical name
- tertiapin-Q
- Canonical SMILES
- CCC(C)C1C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC3CSSCC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC3=O)CC4=CNC5=CC=CC=C54)CCCCN)CCCCN)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)N)C(=O)NC(C(=O)N1)CC(=O)N)CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(C)N)CCC(=
- Isomeric SMILES
- CC[C@H](C)[C@H]1C(=O)NC(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]3CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CC4=CNC5=CC=CC=C54)CCCCN)CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N)C(=O)N[C@H](C(=O)N1)CC(=O)N)CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)CCC(=O)N)CC6=CNC=N6)[C@@H](C)CC)[C@@H](C)CC
- InChI
- InChI=1S/C100H163N31O23S4/c1-10-52(6)79-98(152)129-80(53(7)11-2)99(153)130-81(54(8)12-3)100(154)131-37-23-30-74(131)97(151)123-67(40-57-44-110-50-113-57)91(145)118-64(31-32-75(106)132)88(142)125-71-47-157-158-48-72(126-89(143)65(38-51(4)5)119-83(137)55(9)105)95(149)121-68(41-76(107)133)92(146)127-73(96(150)122-69(42-77(108)134)93(147)128-79)49-156-155-46-70(84(138)112-45-78(135)114-61(27-16-20-34-102)85(139)115-60(82(109)136)26-15-19-33-101)124-87(141)63(29-18-22-36-104)116-86(140)62(28-17-21-35-103)117-90(144)66(120-94(71)148)39-56-43-111-59-25-14-13-24-58(56)59/h13-14,24-25,43-44,50-55,60-74,79-81,111H,10-12,15-23,26-42,45-49,101-105H2,1-9H3,(H2,106,132)(H2,107,133)(H2,108,134)(H2,109,136)(H,110,113)(H,112,138)(H,114,135)(H,115,139)(H,116,140)(H,117,144)(H,118,145)(H,119,137)(H,120,148)(H,121,149)(H,122,150)(H,123,151)(H,124,141)(H,125,142)(H,126,143)(H,127,146)(H,128,147)(H,129,152)(H,130,153)/t52-,53-,54-,55-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,79-,80?,81-/m0/s1
- InChIKey
- GYOKDEHVCCTTJF-VJPNZKQTSA-N
- IUPAC name
- (1R,4S,7S,10S,16S,22S,25S,28R,33R,36S,39S,42S,49R,52S)-36,39-bis(4-aminobutyl)-N-[2-[[(2S)-6-amino-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-25,52-bis(2-amino-2-oxoethyl)-4-(3-amino-3-oxopropyl)-49-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-methylpentanoyl]amino]-16,19,22-tris[(2S)-butan-2-yl]-7-(1H-imidazol-4-ylmethyl)-42-(1H-indol-3-ylmethyl)-3,6,9,15,18,21,24,27,35,38,41,44,50,53-tetradecaoxo-30,31,46,47-tetrathia-2,5,8,14,17,20,23,26,34,37,40,43,51,54-tetradecazatricyclo[26.16.10.010,14]tetrapentacontane-33-carboxamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
Sold under license granted by the University of Pennsylvania.
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2 product images
Chemical Structure - Tertiapin Q, blocker of inward-rectifier r K+ channels (ab120432)
2D chemical structure image of ab120432, Tertiapin Q, blocker of inward-rectifier r K+ channels
Image from Montalbano A, et al. Plos One, 10(10), e0140369. Fig 3,; doi: 10.1371/journal.pone.0140369Cellular Activation - Tertiapin Q, blocker of inward-rectifier r K+ channels (ab120432)
Tertiapin Q, blocker of inward-rectifier r K+ channels
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