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AB142080

Tetrahydrouridine, cytidine deaminase inhibitor

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(1 Publication)

Tetrahydrouridine (ab142080) is a potent competitive cytidine deaminase (CDA) inhibitor (IC50= 152 µM) that modulates antiproliferative effects. The molecular weight of Tetrahydrouridine (THU) is 248.23 g/mol.

- Orally active
- Available in different sizes to fit your experiment needs
1 Images
Chemical Structure - Tetrahydrouridine, cytidine deaminase inhibitor (AB142080)
  • Chemical Structure

Lab

Chemical Structure - Tetrahydrouridine, cytidine deaminase inhibitor (AB142080)

2D chemical structure image of ab142080, Tetrahydrouridine, cytidine deaminase inhibitor

Key facts

CAS number

18771-50-1

Purity

>80%

Molecular weight

248.23 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>6</sub>

PubChem

270480

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-

Biological description

Competitive cytidine deaminase inhibitor (IC50= 152 μM). Modulates antiproliferative effects. Orally active.

Canonical smiles

C1CN(C(=O)NC1O)C2C(C(C(O2)CO)O)O

InChi

InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)

InChiKey

UCKYOOZPSJFJIZ-UHFFFAOYSA-N

IUPAC Name

1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

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Product details

Tetrahydrouridine (THU) is a synthetic pyrimidine nucleoside analogue and is a well characterized and potent inhibitor of cytidine deaminase (CDA). Cytidine deaminase is a key enzyme involved in the pyrimidine salvage pathway.

Use our Tetrahydrouridine, cytidine deaminase inhibitor (ab142080) for applications related to nucleotide metabolism and cancer-programmed cell death.

This product is manufactured by BioVision, an Abcam company and was previously called 1671 Tetrahydrouridine. 1671-25 is the same size as the 25 mg size of ab142080.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:4451 PubMed40360497

2025

Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs.

Applications

Unspecified application

Species

Unspecified reactive species

Julie A I Thoms,Feng Yan,Henry R Hampton,Sarah Davidson,Swapna Joshi,Jesslyn Saw,Chowdhury H Sarowar,Xin Ying Lim,Andrea C Nunez,Purvi M Kakadia,Golam Sarower Bhuyan,Xiaoheng Zou,Mary Nguyen,Elaheh S Ghodousi,Forrest C Koch,Fatemeh Vafaee,I Richard Thompson,Mohammad M Karimi,Russell Pickford,Mark J Raftery,Sally Hough,Griselda Buckland,Michelle Bailey,Yuvaraj Ghodke,Noorul Absar,Lachlin Vaughan,Leonardo Pasalic,Chun Y Fong,Melita Kenealy,Devendra K Hiwase,Rohanna I Stoddart,Soma Mohammed,Linda Lee,Freda H Passam,Stephen R Larsen,Kevin J Spring,Kristen K Skarratt,Patricia Rebeiro,Peter Presgrave,William S Stevenson,Silvia Ling,Campbell Tiley,Stephen J Fuller,Fernando Roncolato,Anoop K Enjeti,Dirk Hoenemann,Charlotte Lemech,Christopher J Jolly,Stefan K Bohlander,David J Curtis,Jason W H Wong,Ashwin Unnikrishnan,Mark Hertzberg,Jake Olivier,Mark N Polizzotto,John E Pimanda
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Biochemicals

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Chemical Structure - Tetrahydrouridine (aqueous solution), cytidine deaminase inhibitor (AB146617)

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

AB178846

Anti-Iba1 antibody [EPR16588] - Microglia marker

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Iba1 antibody [EPR16588] - Microglia marker (AB178846)

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Product promise

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