Tetrandrine, Calcium channel blocker

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(3 Publications)

MW 622.7 Da, Purity >98%. Calcium channel blocker. (IC₅₀ values are 8 and 20 μM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling.

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7TM receptor, ACM2_HUMAN, ACM3_HUMAN, ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, AI838772, ASL13, ATX2_HUMAN, AW493413, Acetylcholine receptor muscarinic 5, Acetylcholine receptor, muscarinic, 2, Antigen NY-CO-13, Ataxin-2, Atxn2, BCC7, CAC1C_HUMAN, CAC1D_HUMAN, CAC1S_HUMAN, CACH 2, CACH1, CACH3, CACN 2, CACN1, CACN4, CACNA 1D, CACNL1A1, CACNL1A2, CACNL1A3, CCHL1A1, CCHL1A2, CCHL1A3, CHKM5MR, CHRM 2, CHRM 3, CHRM1, CM2, CaV1.2, Cach1b, Calcium channel, Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle, Calcium channel L type alpha 1 polypeptide isoform 2, Calcium channel cardic dihydropyridine sensitive alpha 1 subunit, Calcium channel neuroendocrine/brain type alpha 1 subunit, Calcium channel voltage dependent L type alpha 1, Calcium channel voltage dependent L type alpha 1C subunit, Calcium channel voltage dependent L type alpha 1D subunit, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, hypokalemic periodic paralysis, Calcium channel, skeletal muscle dihydropyridine sensitive , alpha 1 subunit, Calcium channel, voltage dependent, L type, alpha 1S subunit, Calcium channel, voltage-dependent, L type, alpha 1S subunit, b, Cav1.1, Cav1.3, Cellular tumor antigen p53, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 2, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Cholinergic receptor, muscarinic 2, cardiac, Cholinergic receptor, muscarinic 2, isoform a, Cholinergic receptor, muscarinic 2a, Chrm 4, Chrm 5, Cytosolic NADP-isocitrate dehydrogenase, DHPR alpha 1, DHPR alpha 1 subunit, Dihydropyridine receptor, Dihydropyridine sensitive L type calcium channel alpha 1 subunit, EGBRS, Epididymis luminal protein 216, Epididymis secretory protein Li 26, FLJ11090, FLJ43243, FLJ92943, HEL-216, HEL-S-26, HM 2, HM 3, HM 4, HM 5, HM1, HOKPP, HypoPP, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, L type, LFS1, LQT8, M2 muscarinic receptor, M2-mAChR, M3 muscarinic receptor, M4, M5R, MGC104252, MGC112732, MGC120006, MGC120007, MGC41838, MHS5, Malignant hyperthermia susceptibility 5, Muscarinic M2 receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Mutant tumor protein 53, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, Olivopontocerebellar ataxia 2, autosomal dominant, Oxalosuccinate decarboxylase, P53_HUMAN, PASNA, PICD, Phosphoprotein p53, ROB1, RP24-311F12.2, SANDD, SCAN1, Spinocerebellar ataxia type 2 protein, TNRC13, TRP53, TS, TTPP1, TYDP, TYDP1_HUMAN, Tp53, Transformation related protein 53, Trinucleotide repeat containing 13, Trinucleotide repeat-containing gene 13 protein, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Voltage dependent L type calcium channel alpha 1C subunit, Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*, Voltage gated calcium channel alpha 1 subunit, Voltage gated calcium channel alpha subunit Cav1.2, Voltage gated calcium channel alpha subunit Cav1.3, Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-gated calcium channel subunit alpha Cav1.1, Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-gated calcium channel subunit alpha Cav1.3, alpha-1 polypeptide, cardiac muscle, cholinergic receptor muscarinic 3, chrm2a, fmd, isoform 1, isoform 2, isoform 3, m3 muscarinic acetylcholine receptor, m5, muscarinic 3, muscarinic cholinergic m3 receptor, muscarinic m3 receptor, p53 tumor suppressor, sj, tumor antigen p55