MW 622.7 Da, Purity >98%. Calcium channel blocker. (IC50 values are 8 and 20 μM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling.
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- Science (New York, N.Y.) 367:301-3052019Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSpencer A Freeman,Stefan Uderhardt,Amra Saric,Richard F Collins,Catherine M Buckley,Sivakami Mylvaganam,Parastoo Boroumand,Jonathan Plumb,Ronald N Germain,Dejian Ren,Sergio GrinsteinPubMed 31806695
- PloS one 11:e01496512016The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarkus Hoffmann et. al.PubMed 26901159
Key facts
- CAS number
- 518-34-3
- Purity
- > 98%
- Form
- Solid
- Source
- Stephania tetrandra
- Molecular weight
- 622.7 Da
- Molecular formula
- C38H42N2O6
- PubChem identifier
- 73078
- Nature
- Native
Target data
Alternative names
7TM receptor, ACM2_HUMAN, ACM3_HUMAN, ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, AI838772, ASL13, ATX2_HUMAN, AW493413, Acetylcholine receptor muscarinic 5, Acetylcholine receptor, muscarinic, 2, Antigen NY-CO-13, Ataxin-2, Atxn2, BCC7, CAC1C_HUMAN, CAC1D_HUMAN, CAC1S_HUMAN, CACH 2, CACH1, CACH3, CACN 2, CACN1, CACN4, CACNA 1D, CACNL1A1, CACNL1A2, CACNL1A3, CCHL1A1, CCHL1A2, CCHL1A3, CHKM5MR, CHRM 2, CHRM 3, CHRM1, CM2, CaV1.2, Cach1b, Calcium channel, Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle, Calcium channel L type alpha 1 polypeptide isoform 2, Calcium channel cardic dihydropyridine sensitive alpha 1 subunit, Calcium channel neuroendocrine/brain type alpha 1 subunit, Calcium channel voltage dependent L type alpha 1, Calcium channel voltage dependent L type alpha 1C subunit, Calcium channel voltage dependent L type alpha 1D subunit, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, Calcium channel, L type, alpha 1 polypeptide, isoform 3, skeletal muscle, hypokalemic periodic paralysis, Calcium channel, skeletal muscle dihydropyridine sensitive , alpha 1 subunit, Calcium channel, voltage dependent, L type, alpha 1S subunit, Calcium channel, voltage-dependent, L type, alpha 1S subunit, b, Cav1.1, Cav1.3, Cellular tumor antigen p53, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 2, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Cholinergic receptor, muscarinic 2, cardiac, Cholinergic receptor, muscarinic 2, isoform a, Cholinergic receptor, muscarinic 2a, Chrm 4, Chrm 5, Cytosolic NADP-isocitrate dehydrogenase, DHPR alpha 1, DHPR alpha 1 subunit, Dihydropyridine receptor, Dihydropyridine sensitive L type calcium channel alpha 1 subunit, EGBRS, Epididymis luminal protein 216, Epididymis secretory protein Li 26, FLJ11090, FLJ43243, FLJ92943, HEL-216, HEL-S-26, HM 2, HM 3, HM 4, HM 5, HM1, HOKPP, HypoPP, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, L type, LFS1, LQT8, M2 muscarinic receptor, M2-mAChR, M3 muscarinic receptor, M4, M5R, MGC104252, MGC112732, MGC120006, MGC120007, MGC41838, MHS5, Malignant hyperthermia susceptibility 5, Muscarinic M2 receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Mutant tumor protein 53, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, Olivopontocerebellar ataxia 2, autosomal dominant, Oxalosuccinate decarboxylase, P53_HUMAN, PASNA, PICD, Phosphoprotein p53, ROB1, RP24-311F12.2, SANDD, SCAN1, Spinocerebellar ataxia type 2 protein, TNRC13, TRP53, TS, TTPP1, TYDP, TYDP1_HUMAN, Tp53, Transformation related protein 53, Trinucleotide repeat containing 13, Trinucleotide repeat-containing gene 13 protein, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Voltage dependent L type calcium channel alpha 1C subunit, Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*, Voltage gated calcium channel alpha 1 subunit, Voltage gated calcium channel alpha subunit Cav1.2, Voltage gated calcium channel alpha subunit Cav1.3, Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-gated calcium channel subunit alpha Cav1.1, Voltage-gated calcium channel subunit alpha Cav1.2, Voltage-gated calcium channel subunit alpha Cav1.3, alpha-1 polypeptide, cardiac muscle, cholinergic receptor muscarinic 3, chrm2a, fmd, isoform 1, isoform 2, isoform 3, m3 muscarinic acetylcholine receptor, m5, muscarinic 3, muscarinic cholinergic m3 receptor, muscarinic m3 receptor, p53 tumor suppressor, sj, tumor antigen p55
Recommended products
MW 622.7 Da, Purity >98%. Calcium channel blocker. (IC50 values are 8 and 20 μM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling.
Key facts
- CAS number
- 518-34-3
- Purity
- > 98%
- Form
- Solid
- Source
- Stephania tetrandra
- Molecular weight
- 622.7 Da
- Molecular formula
- C38H42N2O6
- PubChem identifier
- 73078
- Nature
- Native
- Solubility
Soluble in ethanol to 5 mM.
Soluble in DMSO to 5 mM.
- Biochemical name
- Tetrandrine
- Biological description
Calcium channel blocker. (IC50 values are 8 and 20 μM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling.
- Canonical SMILES
- CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
- Isomeric SMILES
- CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
- InChI
- InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
- InChIKey
- WVTKBKWTSCPRNU-KYJUHHDHSA-N
- IUPAC name
- (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Product promise
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Chemical Structure - Tetrandrine, Calcium channel blocker (ab142464)
2D chemical structure image of ab142464, Tetrandrine, Calcium channel blocker
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