MW 258.23 Da, Purity >99%. Immunomodulator. Antiproliferative, antiangiogenic and pro-apoptotic. Achieve your results faster with highly validated, pure and trusted compounds.
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- iScience 26:1070592023iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHabib Bouguenina,Stephanos Nicolaou,Yann-Vaï Le Bihan,Elizabeth A Bowling,Cheyenne Calderon,John J Caldwell,Brinley Harrington,Angela Hayes,P Craig McAndrew,Costas Mitsopoulos,Fernando Jr Sialana,Andrea Scarpino,Mark Stubbs,Arjun Thapaliya,Siddhartha Tyagi,Hannah Z Wang,Francesca Wood,Rosemary Burke,Florence Raynaud,Jyoti Choudhary,Rob L M van Montfort,Amine Sadok,Thomas F Westbrook,Ian Collins,Rajesh ChopraPubMed 37360684
- Frontiers in medicine 9:8999982022The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum.Applications:Unspecified applicationReactive species:Unspecified reactive speciesThabatta Leal Silveira Andrezo Rosa,Mayara Abud Mendes,Natasha Ribeiro Cardoso Linhares,Thais Fernanda Rodrigues,André Alves Dias,Thyago Leal-Calvo,Mariana Gandini,Helen Ferreira,Fabrício da Mota Ramalho Costa,Anna Maria Sales,Thaís Porto Amadeu,Veronica Schmitz,Roberta Olmo Pinheiro,Luciana Silva Rodrigues,Milton Ozório Moraes,Maria Cristina Vidal PessolaniPubMed 35733868
- Oncotarget 8:88670-886882017Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLewis A Quayle et. al.PubMed 29179466
Key facts
- CAS number
- 50-35-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 258.23 Da
- Molecular formula
- C13H10N2O4
- PubChem identifier
- 5426
- Nature
- Synthetic
Target data
Alternative names
2610203G15Rik, 2900045O07Rik, AF229032, AW108261, CRBN_HUMAN, Cereblon, DKFZp781K0715, MGC27358, MRT2A, OTTHUMP00000209555, Protein cereblon, Protein x 0001, piL
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MW 258.23 Da, Purity >99%. Immunomodulator. Antiproliferative, antiangiogenic and pro-apoptotic. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 50-35-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 258.23 Da
- Molecular formula
- C13H10N2O4
- PubChem identifier
- 5426
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 25 mM.
- Biochemical name
- Thalidomide
- Biological description
Immunomodulator. Antiproliferative, antiangiogenic and pro-apoptotic.
- Canonical SMILES
- C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
- InChI
- InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
- InChIKey
- UEJJHQNACJXSKW-UHFFFAOYSA-N
- IUPAC name
- 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CRBN also known as cereblon is a protein involved in the regulation of protein homeostasis. It has a molecular weight of approximately 51 kDa. CRBN is expressed in various tissues including the brain kidney and muscle. It functions as a substrate receptor for the CRL4-CRBN E3 ubiquitin ligase complex recognizing proteins for ubiquitination and degradation. The chemical structure of thalidomide shows binding affinity to CRBN influencing its function.
- Biological function summary
Cereblon plays a role in the regulation of protein stability and degradation. It forms part of the CRL4-CRBN complex which tags specific proteins for ubiquitination and subsequent proteasomal degradation. This function is critical for maintaining cellular protein balance. Additionally CRBN modulates immune response and has immunomodulator properties influencing cell-mediated responses.
- Pathways
CRBN participates in the ubiquitin-proteasome pathway which regulates protein turnover and quality control within cells. Moreover CRBN is involved in immune signaling pathways partly by modulating the expression of various cytokines and immune-related proteins. It interacts with proteins such as DDB1 and CUL4 within these pathways impacting cellular responses to stress and immune challenges.
- Associated diseases and disorders
CRBN is associated with multiple myeloma and intellectual disability. Cereblon acts as a target for drugs like thalidomide and lenalidomide which are used in the treatment of multiple myeloma by altering ubiquitination processes. In intellectual disability alterations in CRBN function or expression can disrupt neuronal development and signaling. CRBN interacts with proteins like IKZF1 and IKZF3 within these contexts affecting their roles in disease progression and treatment responses.
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Chemical Structure - (±)-Thalidomide, Immunomodulator and anticancer agent (ab120032)
2D chemical structure image of ab120032, Thalidomide, Immunomodulator and anticancer agent
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