JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB146193

Thiamet G, O-GlcNAcase inhibitor

Be the first to review this product! Submit a review

|

(2 Publications)

MW 248.3 Da. Potent, selective O-GlcNAcase inhibitor (Ki = 21 nM). Blocks tau phosphorylation. Increases O-GlcNAc-modified protein levels (EC50 = 30 nM). Shows antitauopathic effects in vivo. Orally active. Blood-brain barrier permeable.
1 Images
Chemical Structure - Thiamet G, O-GlcNAcase inhibitor (AB146193)
  • Chemical Structure

Lab

Chemical Structure - Thiamet G, O-GlcNAcase inhibitor (AB146193)

2D chemical structure image of ab146193, Thiamet G, O-GlcNAcase inhibitor

Key facts

Form

Solid

form

Molecular weight

248.3 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>4</sub>S

PubChem

53393934

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

CID 53393934

Biological description

Potent, selective O-GlcNAcase inhibitor (Ki = 21 nM). Blocks tau phosphorylation. Increases O-GlcNAc-modified protein levels (EC50 = 30 nM). Shows antitauopathic effects in vivo. Orally active. Blood-brain barrier permeable.

Canonical smiles

CCNC1=NC2C(C(C(OC2S1)CO)O)O

Isomeric smiles

CCNC1=NC2C(C(C(OC2S1)CO)O)O

InChi

InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)

InChiKey

PPAIMZHKIXDJRN-UHFFFAOYSA-N

IUPAC Name

2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol

style
left-column

Complementary Products

Biochemicals

AB141254

DBeQ, p97 ATPase inhibitor

Chemical Structure - DBeQ, p97 ATPase inhibitor (AB141254)

  • 0
  • 0
Biochemicals

AB235455

OSMI-1, O-GlcNAc transferase (OGT) inhibitor

  • 0
  • 0
Primary Antibodies

AB22595

Anti-Calnexin antibody - ER Marker

Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Calnexin antibody - ER Marker (AB22595)

  • 5
  • 28
Primary Antibodies

AB180578

Anti-MGAT1 antibody [EPR14247]

RabMAb|Recombinant

Western blot - Anti-MGAT1 antibody [EPR14247] (AB180578)

  • 5
  • 5
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:7430 PubMed39198412

2024

hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Abdolhossein Zare,Saeede Salehi,Jakob Bader,Cornelius Schneider,Utz Fischer,Alexander Veh,Panagiota Arampatzi,Matthias Mann,Michael Briese,Michael Sendtner

BioFactors (Oxford, England) 47:992-1015 PubMed34418170

2021

O-GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics-oriented study.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Weng,Ziyi Wang,Yoko Fukuhara,Airi Tanai,Mika Ikegame,Daisuke Yamada,Takeshi Takarada,Takashi Izawa,Satoru Hayano,Kaya Yoshida,Hiroshi Kamioka,Hirohiko Okamura
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com