MW 248.3 Da. Potent, selective O-GlcNAcase inhibitor (Ki = 21 nM). Blocks tau phosphorylation. Increases O-GlcNAc-modified protein levels (EC50 = 30 nM). Shows antitauopathic effects in vivo. Orally active. Blood-brain barrier permeable.
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- BioFactors (Oxford, England) 47:992-10152021O-GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics-oriented study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYao Weng,Ziyi Wang,Yoko Fukuhara,Airi Tanai,Mika Ikegame,Daisuke Yamada,Takeshi Takarada,Takashi Izawa,Satoru Hayano,Kaya Yoshida,Hiroshi Kamioka,Hirohiko OkamuraPubMed 34418170
- Biochemical and biophysical research communication 453:392-72014Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent paclitaxel.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNing Ding et. al.PubMed 25268318
- PloS one 8:e844422013Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeter Borghgraef et. al.PubMed 24376810
- Neuropharmacology 79:307-132013Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDanielle L Graham,Audrey J Gray,John A Joyce,Dongzi Yu,Jill O'Moore,George A Carlson,Mark S Shearman,Tammy L Dellovade,Heike HeringPubMed 24326295
Key facts
- Form
Solid
- Molecular weight
248.3 Da
- Molecular formula
C9H16N2O4S
- PubChem identifier
53393934
- Nature
Synthetic
Target data
Recommended products
MW 248.3 Da. Potent, selective O-GlcNAcase inhibitor (Ki = 21 nM). Blocks tau phosphorylation. Increases O-GlcNAc-modified protein levels (EC50 = 30 nM). Shows antitauopathic effects in vivo. Orally active. Blood-brain barrier permeable.
Key facts
- Form
Solid
- Molecular weight
248.3 Da
- Molecular formula
C9H16N2O4S
- PubChem identifier
53393934
- Nature
Synthetic
- Solubility
Soluble in DMSO to 50 mM.
- Biochemical name
CID 53393934
- Biological description
Potent, selective O-GlcNAcase inhibitor (Ki = 21 nM). Blocks tau phosphorylation. Increases O-GlcNAc-modified protein levels (EC50 = 30 nM). Shows antitauopathic effects in vivo. Orally active. Blood-brain barrier permeable.
- Canonical SMILES
CCNC1=NC2C(C(C(OC2S1)CO)O)O
- Isomeric SMILES
CCNC1=NC2C(C(C(OC2S1)CO)O)O
- InChI
InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)
- InChIKey
PPAIMZHKIXDJRN-UHFFFAOYSA-N
- IUPAC name
2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - Thiamet G, O-GlcNAcase inhibitor (ab146193)
2D chemical structure image of ab146193, Thiamet G, O-GlcNAcase inhibitor
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