AB120751

Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt

Name: Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (CAS 2390-54-7) | Abcam
Brand: Abcam Limited
SKU: AB120751
Price: 75 USD
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(23 Publications)

MW 318.9 Da, Purity >97%. Fluorescent cell-permeable amyloid binding benzothiazole salt. Dye used to visualise stacked β sheets in vitro and in vivo. Binding induces a shift in excitation maximum (385 nm to 450 nm) and emission maximum (445 nm to 482 nm). Highly soluble in water. Limited ability to cross the blood-brain barrier.

1 Images

Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (AB120751)

Chemical Structure

Lab

Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (AB120751)

2D chemical structure image of ab120751, Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt

Key facts

CAS number

2390-54-7

Purity

>97%

Form

Solid

form

Molecular weight

318.9 Da

Molecular formula

C17H19ClN2S

PubChem

16953

Nature

Synthetic

Solubility

Soluble in water to 25mM

Soluble in DMSO to 100 mM

Biochemical name

Thioflavin T

Biological description

Fluorescent cell-permeable amyloid binding benzothiazole salt. Dye used to visualise stacked β sheets in vitro and in vivo. Binding induces a shift in excitation maximum (385 nm to 450 nm) and emission maximum (445 nm to 482 nm). Highly soluble in water. Limited ability to cross the blood-brain barrier.

Canonical smiles

CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]

InChi

InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChiKey

JADVWWSKYZXRGX-UHFFFAOYSA-M

IUPAC Name

4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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Product protocols

Visit the General protocols
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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eads6132 PubMed40561024

2025

External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics.

Applications

Unspecified application

Species

Unspecified reactive species

Ziming Chen,Peilin Chen,Jiayue Li,Euphemie Landao-Bassonga,John Papadimitriou,Junjie Gao,Delin Liu,Andrew Tai,Jinjin Ma,David Lloyd,Brendan F Kennedy,Ming Hao Zheng

MedComm 6:e70156 PubMed40276647

2025

DEAD-Box Helicase 6 Blockade in Brain-Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxu Wang,Lu Dai,Na Wu,Donghui Wu,Xinyuan Wang,Xia Meng,Qilei Zhang,Jing Lu,Xiaoxin Yan,Jing Zhang,Baian Chen

PLoS biology 23:e3002845 PubMed39982916

2025

RIPK1 is required for ZBP1-driven necroptosis in human cells.

Applications

Unspecified application

Species

Unspecified reactive species

Oluwamuyiwa T Amusan,Shuqi Wang,Chaoran Yin,Heather S Koehler,Yixun Li,Tencho Tenev,Rebecca Wilson,Benjamin Bellenie,Ting Zhang,Jian Wang,Chang Liu,Kim Seong,Seyedeh L Poorbaghi,Joseph Yates,Yuchen Shen,Jason W Upton,Pascal Meier,Siddharth Balachandran,Hongyan Guo

Scientific reports 15:4393 PubMed39910105

2025

Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage.

Applications

Unspecified application

Species

Unspecified reactive species

Diego Alem,César X García-Laviña,Francisco Garagorry,Dardo Centurión,Joaquina Farias,Hany Pazos-Espinosa,María Noel Cuitiño-Mendiberry,Carolina Villadóniga,Susana Castro-Sowinski,Martín Fló,Federico Carrión,Brenda Iglesias,Kevin Madauss,Lucía Canclini

Life science alliance 7: PubMed38171595

2024

Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter.

Applications

Unspecified application

Species

Unspecified reactive species

Ellen Oudejans,Diede Witkamp,Gino V Hu-A-Ng,Leoni Hoogterp,Gemma van Rooijen-van Leeuwen,Iris Kruijff,Pleun Schonewille,Zeinab Lalaoui El Mouttalibi,Imke Bartelink,Marjo S van der Knaap,Truus Em Abbink

Science advances 9:eadi7359 PubMed37967183

2023

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.

Applications

Unspecified application

Species

Unspecified reactive species

Rebecca S Saleeb,Craig Leighton,Ji-Eun Lee,Judi O'Shaughnessy,Kiani Jeacock,Alexandre Chappard,Robyn Cumberland,Tianxiao Zhao,Sarah R Ball,Margaret Sunde,David J Clarke,Kristin Piché,Jacob A McPhail,Ariel Louwrier,Rachel Angers,Sonia Gandhi,Patrick Downey,Tilo Kunath,Mathew H Horrocks

The Journal of clinical investigation 133: PubMed37432737

2023

Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis.

Applications

Unspecified application

Species

Unspecified reactive species

Deepika Awasthi,Sahil Chopra,Byuri A Cho,Alexander Emmanuelli,Tito A Sandoval,Sung-Min Hwang,Chang-Suk Chae,Camilla Salvagno,Chen Tan,Liliana Vasquez-Urbina,Jose J Fernandez Rodriguez,Sara F Santagostino,Takao Iwawaki,E Alfonso Romero-Sandoval,Mariano Sanchez Crespo,Diana K Morales,Iliyan D Iliev,Tobias M Hohl,Juan R Cubillos-Ruiz

Journal of Parkinson's disease 13:841-844 PubMed37393438

2023

Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Linn Oftedal,Jodi Maple-Grødem,Ole-Bjørn Tysnes,Guido Alves,Johannes Lange

Cell reports 33:108266 PubMed33053340

2020

FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.

Applications

Unspecified application

Species

Unspecified reactive species

James C Sears,Kendal Broadie

International journal of molecular sciences 21: PubMed32365658

2020

Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Chiung-Chi Peng,Chang-Rong Chen,Chang-Yu Chen,Yen-Chung Lin,Kuan-Chou Chen,Robert Y Peng

View all publications

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Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt

Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (AB120751)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Complementary Products

Proteins & Peptides

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Handling instructions

Product protocols

Publications (23)

Product promise