AB143556

Thiolutin, antibiotic agent

Name: Thiolutin, antibiotic agent (CAS 87-11-6) | Abcam
Brand: Abcam Limited
SKU: AB143556
Price: 140 USD
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(8 Publications)

MW 228.3 Da, Purity >98%. Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC₅₀ = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo. .

1 Images

Chemical Structure - Thiolutin, antibiotic agent (AB143556)

Chemical Structure

Lab

Chemical Structure - Thiolutin, antibiotic agent (AB143556)

2D chemical structure image of ab143556, Thiolutin, antibiotic agent

Key facts

CAS number

87-11-6

Purity

>98%

Form

Solid

form

Molecular weight

228.3 Da

Molecular formula

C8H8N2O2S2

PubChem

6870

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

Thiolutin

Biological description

Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC₅₀ = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo.

Canonical smiles

CC(=O)NC1=C2C(=CSS2)N(C1=O)C

InChi

InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)

InChiKey

MHMRAFONCSQAIA-UHFFFAOYSA-N

IUPAC Name

N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
Visit the Troubleshooting

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Cell 187:2875-2892.e21 PubMed38626770

2024

Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties.

Applications

Unspecified application

Species

Unspecified reactive species

Gabriela Prus,Shankha Satpathy,Brian T Weinert,Takeo Narita,Chunaram Choudhary

Molecular cell 84:867-882.e5 PubMed38295804

2024

Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils.

Applications

Unspecified application

Species

Unspecified reactive species

Kristian Jeppsson,Biswajit Pradhan,Takashi Sutani,Toyonori Sakata,Miki Umeda Igarashi,Davide Giorgio Berta,Takaharu Kanno,Ryuichiro Nakato,Katsuhiko Shirahige,Eugene Kim,Camilla Björkegren

Science advances 8:eabn7063 PubMed35687682

2022

Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks.

Applications

Unspecified application

Species

Unspecified reactive species

Kristian Jeppsson,Toyonori Sakata,Ryuichiro Nakato,Stefina Milanova,Katsuhiko Shirahige,Camilla Björkegren

Journal of cell science 134: PubMed34350963

2021

The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription.

Applications

Unspecified application

Species

Unspecified reactive species

David Z Kochan,Julia S P Mawer,Jennifer Massen,Kiril Tishinov,Swati Parekh,Martin Graef,Anne Spang,Peter Tessarz

eLife 9: PubMed33095156

2020

Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm complex.

Applications

Unspecified application

Species

Unspecified reactive species

Yulia Vasianovich,Emmanuel Bajon,Raymund J Wellinger

Cells 8: PubMed31200564

2019

Hyperosmotic Stress Response Memory is Modulated by Gene Positioning in Yeast.

Applications

Unspecified application

Species

Unspecified reactive species

Zacchari Ben Meriem,Yasmine Khalil,Pascal Hersen,Emmanuelle Fabre

Molecular cell 70:1054-1066.e4 PubMed29932900

2018

Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Raghuvar Dronamraju,Austin J Hepperla,Yoichiro Shibata,Alexander T Adams,Terry Magnuson,Ian J Davis,Brian D Strahl

Molecular cell 68:130-143.e5 PubMed28918903

2017

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Tiago Baptista,Sebastian Grünberg,Nadège Minoungou,Maria J E Koster,H T Marc Timmers,Steve Hahn,Didier Devys,László Tora

View all publications

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Product promise

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Thiolutin, antibiotic agent

Chemical Structure - Thiolutin, antibiotic agent (AB143556)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Complementary Products

Secondary Antibodies

Assay Kits

Primary Antibodies

Primary Antibodies

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (8)

Product promise