MW 228.3 Da, Purity >98%. Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC50 = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo. .
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- Science advances 8:eabn70632022Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKristian Jeppsson,Toyonori Sakata,Ryuichiro Nakato,Stefina Milanova,Katsuhiko Shirahige,Camilla BjörkegrenPubMed 35687682
- Journal of cell science 134:2021The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDavid Z Kochan,Julia S P Mawer,Jennifer Massen,Kiril Tishinov,Swati Parekh,Martin Graef,Anne Spang,Peter TessarzPubMed 34350963
- eLife 9:2020Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm complex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYulia Vasianovich et. al.PubMed 33095156
- Cells 8:2019Hyperosmotic Stress Response Memory is Modulated by Gene Positioning in Yeast.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZacchari Ben Meriem et. al.PubMed 31200564
- Molecular cell 70:1054-1066.e42018Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRaghuvar Dronamraju,Austin J Hepperla,Yoichiro Shibata,Alexander T Adams,Terry Magnuson,Ian J Davis,Brian D StrahlPubMed 29932900
- Molecular cell 68:130-143.e52017SAGA Is a General Cofactor for RNA Polymerase II Transcription.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTiago Baptista et. al.PubMed 28918903
Key facts
- CAS number
- 87-11-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 228.3 Da
- Molecular formula
- C8H8N2O2S2
- PubChem identifier
- 6870
- Nature
- Synthetic
Target data
Alternative names
IMD42, MGC129539, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RORG_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, TOR
Recommended products
MW 228.3 Da, Purity >98%. Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC50 = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo. .
Key facts
- CAS number
- 87-11-6
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 228.3 Da
- Molecular formula
- C8H8N2O2S2
- PubChem identifier
- 6870
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 10 mM.
- Biochemical name
- Thiolutin
- Biological description
Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC50 = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo.
- Canonical SMILES
- CC(=O)NC1=C2C(=CSS2)N(C1=O)C
- InChI
- InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
- InChIKey
- MHMRAFONCSQAIA-UHFFFAOYSA-N
- IUPAC name
- N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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Chemical Structure - Thiolutin, antibiotic agent (ab143556)
2D chemical structure image of ab143556, Thiolutin, antibiotic agent
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