Thiorphan, Neprilysin/neutral endopeptidase inhibitor

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD10 also known as neprilysin or neutral endopeptidase is a zinc-dependent metalloprotease with a molecular mass of approximately 100 kDa. It is predominantly expressed in various tissues such as kidney lung intestine and liver. Besides CD10 is found on the surface of certain types of immune cells like lymphocytes and neutrophils. As an enzyme it plays a role in the proteolytic cleavage of peptides by releasing their terminal amino acids except those blocked by proline.

Biological function summary

CD10 acts to modulate peptide signaling by degrading bioactive peptides including enkephalins natriuretic peptides and bradykinin. It does not function as part of a complex but participates individually in the regulation and termination of signaling events at the cellular surface. This action ensures the precise control over processes like inflammation blood pressure regulation and pain sensation by inhibiting excessive peptide activity through its enzymatic action.

Pathways

CD10 plays an important role in the renin-angiotensin system and the natriuretic peptide system. In these pathways CD10 interacts with angiotensin converting enzyme 1 often regulating blood pressure and fluid balance. In addition CD10's ability to degrade peptides contributes to the maintenance of endocrine and neuroendocrine homeostasis impacting cellular communication and signaling within these pathways.

The malfunction or altered expression of CD10 can lead to hypertension and heart failure. These disorders relate to its role in regulating the renin-angiotensin and natriuretic peptide systems. Additionally a relationship exists between CD10 and Nrf2 in cellular stress response modulation linking to oxidative stress conditions. Through these associations CD10 remains a potential therapeutic target for disease intervention strategies involving cardiovascular and neurodegenerative diseases.