Tiagabine hydrochloride, GAT-1 inhibitor

• FuncS

PubMed

Functional Studies - Tiagabine hydrochloride, GAT-1 inhibitor (AB120237)

Tiagabine restored LTD via the activation of GABA_B receptors in LPS animals.

Tiagabine (20 μM) and/or CGP55845 {"type" : "entrez-protein","attrs" : {"text" : "CGP55845","term_id" : "875097176","term_text" : "CGP55845"}}(1 μM) were applied in the perfusate during both the recording of baseline activity and LFS (1 Hz stimulation, 15 min) delivery. (Panel A) Time-course and recapitulative graph depicting LTD induction in control (SAL) animals. LFS induced an LTD of fEPSP amplitude in control animals (SAL; filled circles; N = 8), which was significantly blocked by the GABA_B receptor antagonist CGP55845 {"type" : "entrez-protein","attrs" : {"text" : "CGP55845","term_id" : "875097176","term_text" : "CGP55845"}}(SAL+CGP; open circles; N = 5; * p<0.05 vs SAL group). Tiagabine had no significant effect on LTD level (SAL+T; filled triangles; N = 8).

Rideau Batista Novais et al PLoS One. 2014 Sep 3;9(9):e106302. doi: 10.1371/journal.pone.0106302. eCollection 2014. Fig 4. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

• Chemical Structure

Lab

Chemical Structure - Tiagabine hydrochloride, GAT-1 inhibitor (AB120237)

2D chemical structure image of ab120237, Tiagabine hydrochloride, GAT-1 inhibitor