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AB120793

TMPyP4 tosylate, Telomerase inhibitor

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(2 Publications)

MW 1363.6 g/mol, Purity >94%. Cationic porphyrin. Telomerase inhibitor (IC50 = 6.5 μM). Binds and stabilizes DNA G quadruplexes resulting in telomerase inhibition. Displays antitumor effect.
2 Images
Immunocytochemistry/ Immunofluorescence - TMPyP4 tosylate, Telomerase inhibitor (AB120793)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - TMPyP4 tosylate, Telomerase inhibitor (AB120793)

ab2893 staining γH2A.X in weri cells treated with TMPyP4 tosylate (ab120793), by ICC/IF. Increase of γH2A.X nuclear expression correlates with increased concentration of TMPyP4 tosylate, as described in literature.
The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab120793 (TMPyP4 tosylate ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2893 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - TMPyP4 tosylate, Telomerase inhibitor (AB120793)
  • Chemical Structure

Lab

Chemical Structure - TMPyP4 tosylate, Telomerase inhibitor (AB120793)

2D chemical structure image of ab120793, TMPyP4 tosylate, Telomerase inhibitor

Key facts

CAS number

36951-72-1

Purity

>94%

Form

Solid

form

Molecular weight

1363.6 g/mol

Molecular formula

C<sub>7</sub><sub>2</sub>H<sub>6</sub><sub>6</sub>N<sub>8</sub>O<sub>1</sub><sub>2</sub>S<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biological description

Cationic porphyrin. Telomerase inhibitor (IC50 = 6.5 μM). Binds and stabilizes DNA G quadruplexes resulting in telomerase inhibition. Displays antitumor effect.

IUPAC Name

5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

ACS omega 4:16724-16732 PubMed31646217

2019

Label-Free Telomerase Activity Detection via Electrochemical Impedance Spectroscopy.

Applications

Unspecified application

Species

Unspecified reactive species

Diana C Díaz-Cartagena,Griselle Hernández-Cancel,Dina P Bracho-Rincón,José A González-Feliciano,Lisandro Cunci,Carlos I González,Carlos R Cabrera

Cell reports 25:3422-3434.e7 PubMed30566867

2018

An Integrative Study of Protein-RNA Condensates Identifies Scaffolding RNAs and Reveals Players in Fragile X-Associated Tremor/Ataxia Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Fernando Cid-Samper,Mariona Gelabert-Baldrich,Benjamin Lang,Nieves Lorenzo-Gotor,Riccardo Delli Ponti,Lies-Anne W F M Severijnen,Benedetta Bolognesi,Ellen Gelpi,Renate K Hukema,Teresa Botta-Orfila,Gian Gaetano Tartaglia
View all publications
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