MW 324.5 Da, Purity >99%. Potent, reversible, competitive acetyl-CoA carboxylase (ACC) inhibitor.
Hypolipidemic agent, active in vivo. Cell-permeable.
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- The Journal of biological chemistry 299:1027202022Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShaoyou Liu,Jiarun Lai,Yuanfa Feng,Yangjia Zhuo,Hui Zhang,Yupeng Chen,Jinchuang Li,Xinyue Mei,Yanting Zeng,Jiaming Su,Yulin Deng,Funeng Jiang,Shengbang Yang,Huijing Tan,Chi Tin Hon,Sun Wei,Zhaodong Han,Fen Wang,Weide ZhongPubMed 36410440
- Communications biology 5:2382022Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnna Veprik,Geoffrey Denwood,Dong Liu,Rula Bany Bakar,Valentin Morfin,Kara McHugh,Nchimunya N Tebeka,Laurène Vetterli,Ekaterina Yonova-Doing,Fiona Gribble,Frank Reimann,Kyle L Hoehn,Piers A Hemsley,Jonas Ahnfelt-Rønne,Patrik Rorsman,Quan Zhang,Heidi de Wet,James CantleyPubMed 35304577
- British journal of pharmacology 178:1507-15232021Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCristina Miralpeix,Ana Cristina Reguera,Anna Fosch,Maria Casas,Jaume Lillo,Gemma Navarro,Rafael Franco,Josefina Casas,Stephen P H Alexander,Núria Casals,Rosalía Rodríguez-RodríguezPubMed 33444462
- The Journal of cell biology 219:2020Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaria Casas,Rut Fadó,José Luis Domínguez,Aina Roig,Moena Kaku,Shigeru Chohnan,Montse Solé,Mercedes Unzeta,Alfredo Jesús Miñano-Molina,José Rodríguez-Álvarez,Eamonn James Dickson,Núria CasalsPubMed 32931550
- eLife 8:2019Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarta Palomo-Guerrero et. al.PubMed 31868590
- Molecular and cellular biology 37:2017RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJae Ho Lee et. al.PubMed 28827316
- Cancer biology & therapy 12:80-52011TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNatalya V Guseva,Oskar W Rokhlin,Rebecca A Glover,Michael B CohenPubMed 21525791
- Journal of lipid research 33:843-511992Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster.Applications:Unspecified applicationReactive species:Unspecified reactive speciesC M Arbeeny,D S Meyers,K E Bergquist,R E GreggPubMed 1512511
- Lipids 19:851-61984Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid.Applications:Unspecified applicationReactive species:Unspecified reactive speciesD L Halvorson,S A McCunePubMed 6549204
- Journal of medicinal chemistry 20:781-9119775-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids.Applications:Unspecified applicationReactive species:Unspecified reactive speciesR A Parker,T Kariya,J M Grisar,V PetrowPubMed 406395
Key facts
- CAS number
54857-86-2
- Purity
> 99%
- Molecular weight
324.5 Da
- Molecular formula
C19H32O4
- PubChem identifier
115175
- Nature
Synthetic
Recommended products
MW 324.5 Da, Purity >99%. Potent, reversible, competitive acetyl-CoA carboxylase (ACC) inhibitor.
Hypolipidemic agent, active in vivo. Cell-permeable.
Key facts
- CAS number
54857-86-2
- Purity
> 99%
- Molecular weight
324.5 Da
- Molecular formula
C19H32O4
- PubChem identifier
115175
- Nature
Synthetic
- Solubility
Soluble in DMSO to 25 mM. Soluble in ethanol.
- Biochemical name
5-(Tetradecyloxy)-2-furoic acid
- Biological description
Potent, reversible, competitive acetyl-CoA carboxylase (ACC) inhibitor.
Hypolipidemic agent, active in vivo. Cell-permeable.- Canonical SMILES
CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O
- InChI
InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
- InChIKey
CZRCFAOMWRAFIC-UHFFFAOYSA-N
- IUPAC name
5-tetradecoxyfuran-2-carboxylic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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Chemical Structure - TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. (ab141578)
2D chemical structure image of ab141578, TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor.
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