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MW 312.37 Da, Purity >99%. Potent, cell-permeable Janus kinase 3 (JAK3) inhibitor with some JAK1 inhibitory activity as well. Pyrrolo[2,3-d]pyrimidine derivative. Blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity.

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Images

Chemical Structure - Tofacitinib, Janus kinase (JAK) inhibitor (AB142068), expandable thumbnail

Key facts

CAS number
477600-75-2
Purity
> 99%
Form
Solid
Molecular weight
312.37 Da
Molecular formula
C16H20N6O
PubChem identifier
9926791
Nature
Synthetic

Target data

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MW 312.37 Da, Purity >99%. Potent, cell-permeable Janus kinase 3 (JAK3) inhibitor with some JAK1 inhibitory activity as well. Pyrrolo[2,3-d]pyrimidine derivative. Blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity.

Key facts

Purity
> 99%
PubChem identifier
9926791
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
Tofacitinib
Biological description

Potent, cell-permeable Janus kinase 3 (JAK3) inhibitor with some JAK1 inhibitory activity as well. Pyrrolo[2,3-d]pyrimidine derivative. Blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity.

Canonical SMILES
CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N
Isomeric SMILES
C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N
InChI
InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
InChIKey
UJLAWZDWDVHWOW-YPMHNXCESA-N
IUPAC name
3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

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1 product image

  • Chemical Structure - Tofacitinib, Janus kinase (JAK) inhibitor (ab142068), expandable thumbnail

    Chemical Structure - Tofacitinib, Janus kinase (JAK) inhibitor (ab142068)

    2D chemical structure image of ab142068, Tofacitinib, Janus kinase (JAK) inhibitor

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Product protocols

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