MW 270.35 Da, Purity >99%. Blocker of ATP-sensitive (KIR6.x) inward rectifier K+ channels. Achieve your results faster with highly validated, pure and trusted compounds.
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- Communications biology 5:7792022Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBryan J González,Haoquan Zhao,Jacqueline Niu,Damian J Williams,Jaeyop Lee,Chris N Goulbourne,Yuan Xing,Yong Wang,Jose Oberholzer,Maria H Blumenkrantz,Xiaojuan Chen,Charles A LeDuc,Wendy K Chung,Henry M Colecraft,Jesper Gromada,Yufeng Shen,Robin S Goland,Rudolph L Leibel,Dieter EgliPubMed 35918471
Key facts
- CAS number
- 64-77-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 270.35 Da
- Molecular formula
- C12H18N2O3S
- PubChem identifier
- 5505
- Nature
- Synthetic
Target data
Alternative names
ALBU_HUMAN, Albumin (32 AA), Albumin (AA 34), DKFZp779N1935, GIG20, GIG42, OTTHUMP00000220436, OTTHUMP00000220438, OTTHUMP00000220439, PRO0883, PRO0903, PRO1341, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341, cell growth inhibiting protein 42, growth-inhibiting protein 20
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MW 270.35 Da, Purity >99%. Blocker of ATP-sensitive (KIR6.x) inward rectifier K+ channels. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 64-77-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 270.35 Da
- Molecular formula
- C12H18N2O3S
- PubChem identifier
- 5505
- Nature
- Synthetic
- Solubility
DISSOLVES READILY IN AQ NAOH TO FORM SODIUM DERIV.
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- Tolbutamide
- Biological description
Blocker of ATP-sensitive (KIR6.x) inward rectifier K+ channels.
- Canonical SMILES
- CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
- InChI
- InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
- InChIKey
- JLRGJRBPOGGCBT-UHFFFAOYSA-N
- IUPAC name
- 1-butyl-3-(4-methylphenyl)sulfonylurea
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Albumin also known as ALB is a major plasma protein with a molecular mass of approximately 66.5 kDa. It predominantly gets synthesized in the liver and found abundantly in blood plasma. Albumin serves multiple functions including maintaining osmotic pressure and acting as a carrier protein for various endogenous substances like hormones fatty acids and bilirubin.
- Biological function summary
Albumin plays a critical role in transporting small molecules like metabolites and drugs through the circulatory system. It is not a part of any complex but functions independently to bind transport and release various ligands. Albumin's affinity for hydrophobic molecules makes it essential for they to be solubilized in blood for proper metabolism and excretion.
- Pathways
More than five binding sites on albumin facilitate its role in the fatty acid metabolism and renin-angiotensin system pathways. In fatty acid metabolism albumin interacts with transport proteins carrying fatty acids to tissues for energy production. Additionally during the renin-angiotensin system albumin modulates blood pressure through its interaction with angiotensin II which can influence vasoconstriction.
- Associated diseases and disorders
Researchers link albumin with nephrotic syndrome and liver cirrhosis. In nephrotic syndrome low levels of albumin (albumin low) can cause edema due to imbalanced osmotic pressure. In liver cirrhosis a reduction in albumin synthesis signifies liver damage. Albumin's interaction with proteins like angiotensin II correlates with complications such as hypertension further establishing the protein's role in health and disease contexts.
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2 product images
Chemical Structure - Tolbutamide, K+ channel blocker (ab120278)
2D chemical structure image of ab120278, Tolbutamide, K+ channel blocker
Functional Studies - Tolbutamide, K+ channel blocker (ab120278)
U-87 MG cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and 200 μM of tolbutamide (ab120278) in DMSO. Increased expression of hexokinase type II (ab70360) correlates with an increase in tolbutamide concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab70360 at 2 μg/ml and Anti-beta Actin antibody ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.
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