Tolbutamide, K+ channel blocker
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(1 Publication)
MW 270.35 Da, Purity >99%. Blocker of ATP-sensitive (KIR6.x) inward rectifier K+ channels. Achieve your results faster with highly validated, pure and trusted compounds.
View Alternative Names
ALBU_HUMAN, Albumin (32 AA), Albumin (AA 34), DKFZp779N1935, GIG20, GIG42, OTTHUMP00000220436, OTTHUMP00000220438, OTTHUMP00000220439, PRO0883, PRO0903, PRO1341, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341, cell growth inhibiting protein 42, growth-inhibiting protein 20
- FuncS
Unknown
Functional Studies - Tolbutamide, K+ channel blocker (AB120278)
U-87 MG cells were incubated at 37°C for 30 minutes with vehicle control (0 μM) and 200 μM of tolbutamide (ab120278) in DMSO. Increased expression of hexokinase type II (ab70360) correlates with an increase in tolbutamide concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab70360 at 2 μg/ml and ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.
- Chemical Structure
Lab
Chemical Structure - Tolbutamide, K+ channel blocker (AB120278)
2D chemical structure image of ab120278, Tolbutamide, K+ channel blocker
Properties and storage information
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Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Albumin plays a critical role in transporting small molecules like metabolites and drugs through the circulatory system. It is not a part of any complex but functions independently to bind transport and release various ligands. Albumin's affinity for hydrophobic molecules makes it essential for they to be solubilized in blood for proper metabolism and excretion.
Pathways
More than five binding sites on albumin facilitate its role in the fatty acid metabolism and renin-angiotensin system pathways. In fatty acid metabolism albumin interacts with transport proteins carrying fatty acids to tissues for energy production. Additionally during the renin-angiotensin system albumin modulates blood pressure through its interaction with angiotensin II which can influence vasoconstriction.
Publications (1)
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Communications biology 5:779 PubMed35918471
2022
Applications
Unspecified application
Species
Unspecified reactive species
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