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AB120388

Topotecan hydrochloride (SKF 104864), Topoisomerase inhibitor

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MW 457.9 Da, Purity >98%. Topoisomerase I inhibitor. Water-soluble derivative of camptothecin (ab120115). Anticancer agent.

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A830040C14Rik, ACLS, AI838772, AIS, ANDR_HUMAN, APOPAIN, AR, AR8, ARNT-interacting protein, ARO, ARO1, AW493413, Abacavir hypersensitivity, susceptibility to, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Antigen NY-CO-13, Apoptotic protease Mch-3, Aromatase, Atherosclerosis, susceptibility to, included, BCC7, Basic-helix-loop-helix-PAS protein MOP1, Beta-interferon, CAR, CAR BETA, CARA, CASP3_HUMAN, CASP7_HUMAN, CC3, CMH-1, CMT1A, CMT1E, CP19A_HUMAN, CPP-32, CPP32B, CPV1, CYAR, CYP19, CYPXIX, Car 1, Casp3a, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase 7, Caspase 7 apoptosis related cysteine peptidase, Caspase-3, Caspase-3 subunit p12, Caspase-7 subunit p11, Cell cycle regulated protein kinase, Cellular tumor antigen p53, Class E basic helix-loop-helix protein 78, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, Cyp19a1, Cysteine protease CPP32, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), Cytosolic NADP-isocitrate dehydrogenase, DHTR, DKFZp686N23123, DNA binding protein, DNA topoisomerase 1, DNA topoisomerase I, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Drug-induced liver injury due to flucloxacillin, EC 3.4.22.56, ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen synthase, Estrogen synthetase, Estrogen-related receptor alpha, Estrra, FLJ11090, FLJ92943, Fibroblast interferon, GAS-3, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, Growth Arrest Specific 3, Growth arrest-specific protein 3, HDL cholesterol, augmented response of, to hormone replacement, included, HEL-216, HEL-S-26, HIF-1, HIF-1-alpha, HIF-alpha, HIF1A_HUMAN, HLA class I histocompatibility antigen, B-13 alpha chain, HLA class I histocompatibility antigen, B-14 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, HLA class I histocompatibility antigen, B-18 alpha chain, HLA class I histocompatibility antigen, B-27 alpha chain, HLA class I histocompatibility antigen, B-35 alpha chain, HLA class I histocompatibility antigen, B-37 alpha chain, HLA class I histocompatibility antigen, B-38 alpha chain, HLA class I histocompatibility antigen, B-40 alpha chain, HLA class I histocompatibility antigen, B-41 alpha chain, HLA class I histocompatibility antigen, B-42 alpha chain, HLA class I histocompatibility antigen, B-44 alpha chain, HLA class I histocompatibility antigen, B-45 alpha chain, HLA class I histocompatibility antigen, B-46 alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-48 alpha chain, HLA class I histocompatibility antigen, B-49 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-51 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain, HLA class I histocompatibility antigen, B-53 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-56 alpha chain, HLA class I histocompatibility antigen, B-57 alpha chain, HLA class I histocompatibility antigen, B-58 alpha chain, HLA class I histocompatibility antigen, B-59 alpha chain, HLA class I histocompatibility antigen, B-67 alpha chain, HLA class I histocompatibility antigen, B-7 alpha chain, HLA class I histocompatibility antigen, B-73 alpha chain, HLA class I histocompatibility antigen, B-78 alpha chain, HLA class I histocompatibility antigen, B-8 alpha chain, HLA class I histocompatibility antigen, B-81 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, HMSNIA, HNPP, HUMARA, HYSP1, Hypoxia inducible factor 1 alpha isoform I.3, Hypoxia inducible factor 1 alpha subunit, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor, Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor), Hypoxia-inducible factor 1-alpha, ICDH, ICE-LAP3, ICE-like apoptotic protease 3, ICE3, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, KD, Kennedy disease (KD), LFS1, LICE, LICE2, Lymphocyte antigen, MB67, MCH3, MGC104252, MGC104309, MGC112732, MGC20769, MGC96956, MGC97144, MHC class I antigen B 7, MOP 1, Major Histocompatibility Complex Class I B, Member of PAS protein 1, Member of PAS superfamily 1, Member of the PAS Superfamily 1, Microsomal monooxygenase, Mutant tumor protein 53, Myocardial infarction, susceptibility to, included, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NR1B1, NR1I3_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, NUP98 fusion gene, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group I member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000158659, OTTHUMP00000158660, OTTHUMP00000162543, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, OTTHUMP00000198350, OTTHUMP00000203723, OTTHUMP00000203724, Oncogene GLI3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3, Oxalosuccinate decarboxylase, P 450AROM, P53_HUMAN, PAP A, PAPB, PARP cleavage protease, PAS domain-containing protein 8, PASD 8, PAX8_HUMAN, PICD, PLK, PLK1_HUMAN, PMP22_HUMAN, PPD IV, Paired box 8, Paired box gene 8, Paired box protein Pax-8, Paired domain gene 8, Peripheral myelin protein 22, Phosphoprotein p53, Polo-like kinase 1, Procaspase3, Protein Yama, RAR, RAR-alpha, RARA_HUMAN, RARalpha1, RNESTROR, RP24-311F12.2, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, SBMA, SCA-1, SCAN1, SMAX1, SREBP cleavage activity 1, STPK 13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, Synovitis, chronic, susceptibility to, TFM, TOP I, TOP1_HUMAN, TRP53, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Topoisomerase (DNA) I, Topoisomerase 1, TopoisomeraseI, Tp53, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transformation related protein 53, Trembler, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Type I DNA topoisomerase, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Yama, Yama protein, Zinc finger protein GLI 3, androgen receptor splice variant 4b, bHLHe78, constitutive active receptor, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, hifla, leukocyte antigen class I-B, mldy, orphan nuclear hormone receptor, p53 tumor suppressor, paired box homeotic gene 8, tumor antigen p55

1 Images
Chemical Structure - Topotecan hydrochloride (SKF 104864), Topoisomerase inhibitor (AB120388)
  • Chemical Structure

Lab

Chemical Structure - Topotecan hydrochloride (SKF 104864), Topoisomerase inhibitor (AB120388)

2D chemical structure image of ab120388, Topotecan hydrochloride (SKF 104864), Topoisomerase inhibitor

Key facts

CAS number

119413-54-6

Purity

>98%

Form

Solid

form

Molecular weight

457.9 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>4</sub>ClN<sub>3</sub>O<sub>5</sub>

PubChem

60699

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Topotecan hydrochloride

Biological description

Topoisomerase I inhibitor. Water-soluble derivative of camptothecin (ab120115). Anticancer agent.

Canonical smiles

CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl

Isomeric smiles

CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl

InChi

InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1

InChiKey

DGHHQBMTXTWTJV-BQAIUKQQSA-N

IUPAC Name

(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

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