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AB146171

Toyocamycin, IRE1alpha inhibitor. Adenosine analog.

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MW 291.26 g/mol. Selective IRE1α inhibitor. Adenosine (ab120498) analog. PI3-kinase inhibitor. Inhibits RNA self-cleavage. Induces apoptosis in cancer cell lines. Suppresses thapsigargin-, tunicamycin- and 2-deoxyglucose-induced XBP1 mRNA splicing. Shows antitumor and antimicrobial effects in vivo. .
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Chemical Structure - Toyocamycin, IRE1alpha inhibitor. Adenosine analog. (AB146171)
  • Chemical Structure

Lab

Chemical Structure - Toyocamycin, IRE1alpha inhibitor. Adenosine analog. (AB146171)

2D chemical structure image of ab146171, Toyocamycin, IRE1alpha inhibitor. Adenosine analog.

Key facts

CAS number

606-58-6

Form

Solid

form

Source

Streptomyces rimosus

Molecular weight

291.26 g/mol

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>3</sub>N<sub>5</sub>O<sub>4</sub>

Nature

Native

Biological description

Selective IRE1α inhibitor. Adenosine (ab120498) analog. PI3-kinase inhibitor. Inhibits RNA self-cleavage. Induces apoptosis in cancer cell lines. Suppresses thapsigargin-, tunicamycin- and 2-deoxyglucose-induced XBP1 mRNA splicing. Shows antitumor and antimicrobial effects in vivo.

Isomeric smiles

C1C(C2C(NCNC2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C#N

InChi

InChI=1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1

InChiKey

XOKJUSAYZUAMGJ-WOUKDFQISA-N

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Product promise

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