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AB145522

TPCA 1, IkappaB kinase inhibitor

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(4 Publications)

MW 279.29 Da, Purity >98%. Potent, selective IκB kinase inhibitor (IC50 = 17.9 nM). Inhibits NF-κB nuclear localization. Shows anti-inflammatory effects in vivo. .
1 Images
Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)
  • Chemical Structure

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Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)

2D chemical structure image of ab145522, TPCA 1, IkappaB kinase inhibitor

Key facts

CAS number

507475-17-4

Purity

>98%

Form

Solid

form

Molecular weight

279.29 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>0</sub>FN<sub>3</sub>O<sub>2</sub>S

PubChem

9903786

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide

Biological description

Potent, selective IκB kinase inhibitor (IC50 = 17.9 nM). Inhibits NF-κB nuclear localization. Shows anti-inflammatory effects in vivo.

Canonical smiles

C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

InChi

InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

InChiKey

SAYGKHKXGCPTLX-UHFFFAOYSA-N

IUPAC Name

2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide

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Biochemicals

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Biochemicals

AB141003

MG-132, proteasome inhibitor

Immunocytochemistry/ Immunofluorescence - MG-132, proteasome inhibitor (AB141003)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

European heart journal open 5:oeaf011 PubMed40201592

2025

Modulation of cell fate by shock wave therapy in ischaemic heart disease.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Graber,Can Gollmann-Tepeköylü,Victor Schweiger,Jakob Hirsch,Leo Pölzl,Felix Nägele,Daniela Lener,Hubert Hackl,Sieghart Sopper,Elke Kirchmair,Sophia Mair,Jakob Voelkl,Christina Plattner,Felix Eichin,Zlatko Trajanoski,Anne Krogsdam,Jonas Eder,Manuel Fiegl,Dominik Hau,Ivan Tancevski,Michael Grimm,John P Cooke,Johannes Holfeld

Nature 617:827-834 PubMed37165186

2023

EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.

Applications

Unspecified application

Species

Unspecified reactive species

Sevval Nur Bilgic,Aylin Domaniku,Batu Toledo,Samet Agca,Bahar Z C Weber,Dilsad H Arabaci,Zeynep Ozornek,Pascale Lause,Jean-Paul Thissen,Audrey Loumaye,Serkan Kir

The Journal of experimental medicine 219: PubMed36098746

2022

Induction of natural IgE by glucocorticoids.

Applications

Unspecified application

Species

Unspecified reactive species

Jaechul Lim,Erica V Lin,Jun Young Hong,Bharat Vaidyanathan,Steven A Erickson,Charles Annicelli,Ruslan Medzhitov

Reproduction (Cambridge, England) 159:503-511 PubMed32103820

2020

IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle.

Applications

Unspecified application

Species

Unspecified reactive species

Keigo Nakamura,Kazuya Kusama,Atsushi Ideta,Kazuhiko Imakawa,Masatoshi Hori
View all publications
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