MW 351.8 Da, Purity >98%. Irreversible chymotrypsin inhibitor and SMase inhibitor. Inhibits the activation of PDK1-dependent AGC kinases. Selectively inhibits RSK, Akt and S6K1. Shows antitumor effects in vivo. Centrally active.
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Key facts
- CAS number
- 402-71-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 351.8 Da
- Molecular formula
- C17H18ClNO3S
- PubChem identifier
- 439647
- Nature
- Synthetic
Alternative names
1-acylglycerol-3-phosphate O-acyltransferase ABHD5, ABHD5_HUMAN, AHD2, AL1A1_HUMAN, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH, liver cytosolic, ALDH-E1, ALHDII, Abhydrolase domain containing 5, Abhydrolase domain-containing protein 5, Acetaldehyde dehydrogenase 1, Aldehyde dehydrogenase, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase liver cytosolic, CDS, CGI 58, CGI58 protein, HEL-S-53e, IECN2, LSDA5, Lipid droplet-associated protein, Lipid droplet-binding protein CGI-58, Lipid storage droplet protein 5, MGC2318, MGC8731, MLDP, NCIE2, OXPAT, PLIN, PLIN1_HUMAN, PLIN5_HUMAN, PUMB 1, Perilipin, Perilipin A, Perilipin-1, Perilipin-5, RALDH 1, Retinal dehydrogenase 1, cytosolic, epididymis luminal protein 12, epididymis luminal protein 9, epididymis secretory sperm binding protein Li 53e
Recommended products
MW 351.8 Da, Purity >98%. Irreversible chymotrypsin inhibitor and SMase inhibitor. Inhibits the activation of PDK1-dependent AGC kinases. Selectively inhibits RSK, Akt and S6K1. Shows antitumor effects in vivo. Centrally active.
Key facts
- CAS number
- 402-71-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 351.8 Da
- Molecular formula
- C17H18ClNO3S
- PubChem identifier
- 439647
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 25 mM.
- Biochemical name
- Tosylphenylalanyl chloromethyl ketone
- Biological description
Irreversible chymotrypsin inhibitor and SMase inhibitor. Inhibits the activation of PDK1-dependent AGC kinases. Selectively inhibits RSK, Akt and S6K1. Shows antitumor effects in vivo. Centrally active.
- Canonical SMILES
- CC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CC=CC=C2)C(=O)CCl
- Isomeric SMILES
- CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl
- InChI
- InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1
- InChIKey
- MQUQNUAYKLCRME-INIZCTEOSA-N
- IUPAC name
- N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Perilipin-1 also known as PLIN1 is a lipid droplet-associated protein with a mass of approximately 57 kDa. It belongs to the perilipin family and localizes to the surfaces of intracellular lipid droplets. Perilipin-1 plays an important role in lipid metabolism by regulating the storage and hydrolysis of these lipids. Its expression is abundant in adipose tissues and is prominent in white and brown adipose cells. Other alternate names include lipid droplet-associated protein and perilipin A.
- Biological function summary
This protein acts as a protective barrier for lipid droplets regulating access to lipase enzymes. It interacts closely with proteins such as ALDH1A1 and Abhd5/CGI-58. The latter enhances lipase activity when perilipin-1 undergoes phosphorylation. This dynamic interaction is vital for the efficient mobilization of stored lipids through lipolytic processes. It is part of a complex that includes perilipin family proteins like LSDP5 which also associates with lipid droplets.
- Pathways
Perilipin-1 is integral to the regulation of lipolysis and lipid storage in the metabolic pathway. Key pathways include the cAMP-dependent protein kinase pathway and the broader lipid metabolism pathway. Its interaction with the protein hormone-sensitive lipase (HSL) modulates the breakdown of triacylglycerol to free fatty acids emphasizing its role in energy balance and supply. Perilipin-1's regulation by kinases serves as a checkpoint in lipid mobilization and is important to maintaining energy homeostasis.
- Associated diseases and disorders
Alterations in perilipin-1 expression or function relate to metabolic disorders such as obesity and insulin resistance. Mutations or dysregulation of this protein can disrupt lipid homeostasis contributing to excessive fat storage and impaired energy metabolism. Furthermore its interaction with perilipin 2 also known as ADRP can influence disease progression by affecting lipid droplet dynamics. Understanding perilipin-1’s role in these conditions may offer insights for therapeutic approaches.
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1 product image
Chemical Structure - TPCK, chymotrypsin and SMase inhibitor (ab144608)
2D chemical structure image of ab144608, TPCK, chymotrypsin and SMase inhibitor
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