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AB141116

Tramiprosate, Binds soluble amyloid-beta

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(2 Publications)

MW 139.18 Da. Binds soluble amyloid-β. Antifibrillogenic activity in vitro and in vivo. Sulfated glycosaminoglycan (sGAG) mimetic. Inhibits amyloid-β induced neuronal cytotoxicity. A synthetic GABA analog. Blood-brain barrier permeable and orally active.

View Alternative Names

AW061132, B230208N19Rik, BcDNA:GH07312, CAE 2, CG6706, CT20836, D Gaba2, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, FLJ36928, FLJ92613, G-protein coupled receptor 51, GAA 5, GAB B R2, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor, alpha 1, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABA-B receptor 1, GABA-B receptor 2, GABA-B-R1, GABA-B-R2, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABAB subunit 1c, GABBR1, GABBR1 3, GABR A3, GABR B3, GABR G3, GABR1_HUMAN, GABR2_HUMAN, GABRA 1, GABRA 5, GABRA 6, GABRB2, GABRG 1, GABRG 2, GABRP, GARB1, GBRA1_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GC138184, GEFSP 3, GH07312, GPR 51, GPRC 3B, GPRC3A, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid (GABA) B receptor 1, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid B receptor 2, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid GABA B receptor 2, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, Gamma-aminobutyric-acid receptor subunit beta-2, Gb 2, Gb1, HG 20, HRIHFB2099, MGC116903, MGC116904, MGC126386, MGC126387, MGC33793, MGC45284, MGC9051, Metabotropic GABA B receptor subtype 2, OTTHUMP00000021776, OTTHUMP00000063797, R2 SUBUNIT, Seven transmembrane helix receptor, dJ271M21.1.1, dJ271M21.1.2

1 Images
Chemical Structure - Tramiprosate, Binds soluble amyloid-beta (AB141116)
  • Chemical Structure

Lab

Chemical Structure - Tramiprosate, Binds soluble amyloid-beta (AB141116)

2D chemical structure image of ab141116, Tramiprosate, Binds soluble amyloid-beta

Key facts

CAS number

3687-18-1

Form

Solid

form

Molecular weight

139.18 Da

Molecular formula

C<sub>3</sub>H<sub>9</sub>NO<sub>3</sub>S

PubChem

1646

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Tramiprosate

Biological description

Binds soluble amyloid-β. Antifibrillogenic activity in vitro and in vivo. Sulfated glycosaminoglycan (sGAG) mimetic. Inhibits amyloid-β induced neuronal cytotoxicity. A synthetic GABA analog. Blood-brain barrier permeable and orally active.

Canonical smiles

C(CN)CS(=O)(=O)O

InChi

InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

InChiKey

SNKZJIOFVMKAOJ-UHFFFAOYSA-N

IUPAC Name

3-aminopropane-1-sulfonic acid

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

Product protocols

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40332390

2025

Combination of Epigallocatechin-3-Gallate and Tramiprosate Prevent Accumulation of Intracellular Aβ and Dysfunctional Autophagy-Lysosomal Pathway at Earliest Stage of Transdifferentiation of Mesenchymal Stromal Cells into PSEN1 E280A Cholinergic-like Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Viviana Soto-Mercado,Miguel Mendivil-Perez,Marlene Jimenez-Del-Rio,Carlos Velez-Pardo

International journal of molecular sciences 25: PubMed38732141

2024

Combination of Tramiprosate, Curcumin, and SP600125 Reduces the Neuropathological Phenotype in Familial Alzheimer Disease PSEN1 I416T Cholinergic-like Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Nicolas Gomez-Sequeda,Marlene Jimenez-Del-Rio,Carlos Velez-Pardo
View all publications

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