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MW 327.34 g/mol, Purity >99%. Potent mast cell membrane stabilizer. Exhibits a wide range of anti-inflammatory effects. Inhibits antigen-induced release of cytokines, chemokines and proteases. Able to inhibit angiotensin II induced contractions (IC50 = 36 μM).

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Images

Chemical Structure - Tranilast, Anti-inflammatory agent (AB120643), expandable thumbnail
  • Functional Studies - Tranilast, Anti-inflammatory agent (AB120643), expandable thumbnail

Publications

Key facts

CAS number

53902-12-8

Purity

> 99%

Form

Solid

Molecular weight

327.34 g/mol

Molecular formula

C18H17NO5

Nature

Synthetic

Recommended products

MW 327.34 g/mol, Purity >99%. Potent mast cell membrane stabilizer. Exhibits a wide range of anti-inflammatory effects. Inhibits antigen-induced release of cytokines, chemokines and proteases. Able to inhibit angiotensin II induced contractions (IC50 = 36 μM).

Key facts

Purity

> 99%

Solubility

Soluble in DMSO to 100 mM.

Biological description

Potent mast cell membrane stabilizer. Exhibits a wide range of anti-inflammatory effects. Inhibits antigen-induced release of cytokines, chemokines and proteases. Able to inhibit angiotensin II induced contractions (IC50 = 36 μM).

IUPAC name

N-(3',4'-Dimethoxycinnamoyl)anthranilic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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2 product images

  • Chemical Structure - Tranilast, Anti-inflammatory agent (ab120643), expandable thumbnail

    Chemical Structure - Tranilast, Anti-inflammatory agent (ab120643)

    2D chemical structure image of ab120643, Tranilast, Anti-inflammatory agent

  • Functional Studies - Tranilast, Anti-inflammatory agent (ab120643), expandable thumbnail

    Functional Studies - Tranilast, Anti-inflammatory agent (ab120643)

    ab84833 staining Aryl hydrocarbon receptor in MDA-MB-231 cells treated with tranilast (ab120643), by ICC/IF. Increase in Aryl hydrocarbon receptor expression correlates with increased concentration of tranilast, as described in literature.
    The cells were incubated at 37°C for 24h in media containing different concentrations of ab120643 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab84833 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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Product protocols

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