MW 327.34 g/mol, Purity >99%. Potent mast cell membrane stabilizer. Exhibits a wide range of anti-inflammatory effects. Inhibits antigen-induced release of cytokines, chemokines and proteases. Able to inhibit angiotensin II induced contractions (IC50 = 36 μM).
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- Oncotarget 8:88670-886882017Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLewis A Quayle et. al.PubMed 29179466
Key facts
- CAS number
- 53902-12-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 327.34 g/mol
- Molecular formula
- C18H17NO5
- Nature
- Synthetic
Recommended products
MW 327.34 g/mol, Purity >99%. Potent mast cell membrane stabilizer. Exhibits a wide range of anti-inflammatory effects. Inhibits antigen-induced release of cytokines, chemokines and proteases. Able to inhibit angiotensin II induced contractions (IC50 = 36 μM).
Key facts
- CAS number
- 53902-12-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 327.34 g/mol
- Molecular formula
- C18H17NO5
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biological description
Potent mast cell membrane stabilizer. Exhibits a wide range of anti-inflammatory effects. Inhibits antigen-induced release of cytokines, chemokines and proteases. Able to inhibit angiotensin II induced contractions (IC50 = 36 μM).
- IUPAC name
- N-(3',4'-Dimethoxycinnamoyl)anthranilic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Tranilast, Anti-inflammatory agent (ab120643)
2D chemical structure image of ab120643, Tranilast, Anti-inflammatory agent
Functional Studies - Tranilast, Anti-inflammatory agent (ab120643)
ab84833 staining Aryl hydrocarbon receptor in MDA-MB-231 cells treated with tranilast (ab120643), by ICC/IF. Increase in Aryl hydrocarbon receptor expression correlates with increased concentration of tranilast, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120643 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab84833 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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