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AB120801

TRAP-6, PAR1 agonist

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MW 748.88 g/mol, Purity >95%. Peptide fragment (residues 42 - 47) of protease-activated receptor 1. PAR1 hexapeptide agonist. Stimulates transient mobilization of free intracellular calcium, platelet aggregation (EC50 = 0.8μM) and rapidly phosphorylates PDE3A.
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Functional Studies - TRAP-6, PAR1 agonist (AB120801)
  • FuncS

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Functional Studies - TRAP-6, PAR1 agonist (AB120801)

ab6672 staining IL6 in serum starved PC3 cells treated with TRAP-6 (ab120801), by ICC/IF. Increase in expression of IL6 correlates with increased concentration of TRAP-6, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120801 (TRAP-6) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab6672 (1/500 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - TRAP-6, PAR1 agonist (AB120801)
  • Chemical Structure

Lab

Chemical Structure - TRAP-6, PAR1 agonist (AB120801)

2D chemical structure image of ab120801, TRAP-6, PAR1 agonist

Key facts

CAS number

141136-83-6

Purity

>95%

Molecular weight

748.88 g/mol

Nature

Synthetic

Solubility

Soluble in water to 1 mg/ml

Biological description

Peptide fragment (residues 42 - 47) of protease-activated receptor 1. PAR1 hexapeptide agonist. Stimulates transient mobilization of free intracellular calcium, platelet aggregation (EC50 = 0.8μM) and rapidly phosphorylates PDE3A.

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Biochemicals

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Chemical Structure - AY-NH2, PAR4 agonist peptide (AB120179)

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Proteins & Peptides

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Biochemicals

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13,14-Dihydroprostaglandin E1, Prostaglandin E1 (PGE1) metabolite

Chemical Structure - 13,14-Dihydroprostaglandin E1, Prostaglandin E1 (PGE1) metabolite (AB141716)

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Primary Antibodies

AB16502

Anti-NF-kB p65 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NF-kB p65 antibody (AB16502)

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