MW 207.27 Da, Purity >90%. Potent, specific acyl-CoA synthetase inhibitor (Ki values are 15 nM and 2 μM for Faa2p and Faa4p respectively). Inhibits synthesis of cholesteryl ester and triacylglycerol in vitro. Vasodilator agent. Orally active. Active in vivo and in vitro.
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- Journal of lipid research 64:1004502023Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun-Ichi Morishige,Kazuaki Yoshioka,Hiroki Nakata,Kazuhiro Ishimaru,Naoto Nagata,Tamotsu Tanaka,Yoh Takuwa,Hitoshi AndoPubMed 37751791
- Cancer research 83:2461-24702023Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmmanuel Griessinger,Diego Pereira-Martins,Marielle Nebout,Claudie Bosc,Estelle Saland,Emiline Boet,Ambrine Sahal,Johanna Chiche,Delphine Debayle,Lucile Fleuriot,Maurien Pruis,Véronique De Mas,François Vergez,Christian Récher,Gerwin Huls,Jean-Emmanuel Sarry,Jan Jacob Schuringa,Jean-François PeyronPubMed 37272750
- Cell death discovery 4:1092018Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlex Wong et. al.PubMed 30510774
- Nature communications 7:134572016Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesStephen L Pinkosky et. al.PubMed 27892461
- The Journal of antibiotics 61:318-212008Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaisuke Matsuda,Ichiji Namatame,Taichi Ohshiro,Shun Ishibashi,Satoshi Omura,Hiroshi TomodaPubMed 18653998
- The Journal of biological chemistry 270:20090-71995Comparison of the reactivity of tetradecenoic acids, a triacsin, and unsaturated oximes with four purified Saccharomyces cerevisiae fatty acid activation proteins.Applications:Unspecified applicationReactive species:Unspecified reactive speciesL J Knoll,O F Schall,I Suzuki,G W Gokel,J I GordonPubMed 7650027
- Prostaglandins 37:655-711989Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesE J Hartman,S Omura,M LaposataPubMed 2505330
Key facts
- CAS number
76896-80-5
- Purity
> 90%
- Form
Liquid
- Source
Streptomyces aureofaciens
- Molecular weight
207.27 Da
- Molecular formula
C11H17N3O
- PubChem identifier
9576787
- Nature
Native
Target data
Recommended products
MW 207.27 Da, Purity >90%. Potent, specific acyl-CoA synthetase inhibitor (Ki values are 15 nM and 2 μM for Faa2p and Faa4p respectively). Inhibits synthesis of cholesteryl ester and triacylglycerol in vitro. Vasodilator agent. Orally active. Active in vivo and in vitro.
Key facts
- CAS number
76896-80-5
- Purity
> 90%
- Form
Liquid
- Source
Streptomyces aureofaciens
- Molecular weight
207.27 Da
- Molecular formula
C11H17N3O
- PubChem identifier
9576787
- Nature
Native
- Biochemical name
Triacsin c
- Biological description
Potent, specific acyl-CoA synthetase inhibitor (Ki values are 15 nM and 2 μM for Faa2p and Faa4p respectively). Inhibits synthesis of cholesteryl ester and triacylglycerol in vitro. Vasodilator agent. Orally active. Active in vivo and in vitro.
- Canonical SMILES
CCCC=CCC=CC=CC=NNN=O
- Isomeric SMILES
CCC/C=C/C/C=C/C=C/C=N/NN=O
- InChI
InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+
- InChIKey
NKTGCVUIESDXPU-YLEPRARLSA-N
- IUPAC name
N-[(E)-[(2E,4E,7E)-undeca-2,4,7-trienylidene]amino]nitrous amide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
2D chemical structure image of ab141888, Triacsin C, acyl-CoA synthetase inhibitor
Functional Studies - Triacsin C, acyl-CoA synthetase inhibitor (ab141888)
Triacsin C inhibits the proliferation of 3T3-L1 cells.Cells were treated with different concentrations of Triacsin C (ab141888) for 3 days. The number of live cells was measured by XTT cell proliferation assay kit, normalized to the control (100%) and plotted against the drug concentration.
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