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AB141888

Triacsin C, acyl-CoA synthetase inhibitor

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(5 Publications)

MW 207.27 Da, Purity >90%. Potent, specific acyl-CoA synthetase inhibitor (Ki values are 15 nM and 2 μM for Faa2p and Faa4p respectively). Inhibits synthesis of cholesteryl ester and triacylglycerol in vitro. Vasodilator agent. Orally active. Active in vivo and in vitro.
2 Images
Functional Studies - Triacsin C, acyl-CoA synthetase inhibitor (AB141888)
  • FuncS

Unknown

Functional Studies - Triacsin C, acyl-CoA synthetase inhibitor (AB141888)

Triacsin C inhibits the proliferation of 3T3-L1 cells.Cells were treated with different concentrations of Triacsin C (ab141888) for 3 days. The number of live cells was measured by XTT cell proliferation assay kit, normalized to the control (100%) and plotted against the drug concentration.

Chemical Structure - Triacsin C, acyl-CoA synthetase inhibitor (AB141888)
  • Chemical Structure

Lab

Chemical Structure - Triacsin C, acyl-CoA synthetase inhibitor (AB141888)

2D chemical structure image of ab141888, Triacsin C, acyl-CoA synthetase inhibitor

Key facts

CAS number

76896-80-5

Purity

>90% HPLC

Form

Liquid

form

Molecular weight

207.27 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>7</sub>N<sub>3</sub>O

PubChem

9576787

Nature

Synthetic

Biochemical name

Triacsin c

Biological description

Potent, specific acyl-CoA synthetase inhibitor (Ki values are 15 nM and 2 μM for Faa2p and Faa4p respectively). Inhibits synthesis of cholesteryl ester and triacylglycerol in vitro. Vasodilator agent. Orally active. Active in vivo and in vitro.

Canonical smiles

CCCC=CCC=CC=CC=NNN=O

Isomeric smiles

CCC/C=C/C/C=C/C=C/C=N/NN=O

InChi

InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+

InChiKey

NKTGCVUIESDXPU-YLEPRARLSA-N

IUPAC Name

N-[(E)-[(2E,4E,7E)-undeca-2,4,7-trienylidene]amino]nitrous amide

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Product details

Supplied in DMSO (1 mg/ml).
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Endocrinology 166: PubMed40105689

2025

IGF1 Signaling Regulates Neuropeptide Expression in Hypothalamic Neurons Under Physiological and Pathological Conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyuan He,Neruja Loganathan,Denise D Belsham

Journal of lipid research 64:100450 PubMed37751791

2023

Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Ichi Morishige,Kazuaki Yoshioka,Hiroki Nakata,Kazuhiro Ishimaru,Naoto Nagata,Tamotsu Tanaka,Yoh Takuwa,Hitoshi Ando

Cancer research 83:2461-2470 PubMed37272750

2023

Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold.

Applications

Unspecified application

Species

Unspecified reactive species

Emmanuel Griessinger,Diego Pereira-Martins,Marielle Nebout,Claudie Bosc,Estelle Saland,Emiline Boet,Ambrine Sahal,Johanna Chiche,Delphine Debayle,Lucile Fleuriot,Maurien Pruis,Véronique De Mas,François Vergez,Christian Récher,Gerwin Huls,Jean-Emmanuel Sarry,Jan Jacob Schuringa,Jean-François Peyron

Cell death discovery 4:109 PubMed30510774

2018

Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Alex Wong,Sixun Chen,Lay Kien Yang,Yoganathan Kanagasundaram,Karen Crasta

Nature communications 7:13457 PubMed27892461

2016

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen L Pinkosky,Roger S Newton,Emily A Day,Rebecca J Ford,Sarka Lhotak,Richard C Austin,Carolyn M Birch,Brennan K Smith,Sergey Filippov,Pieter H E Groot,Gregory R Steinberg,Narendra D Lalwani
View all publications
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