Trichostatin A, histone deacetylase inhibitor (CAS 58880-19-6) (ab120850)

MW 302.37 Da, Purity >98%. Potent, selective histone deacetylase (HDAC) inhibitor (K_i = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.

Also available as a solid (ab120850).

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Alternative names=2810449N18Rik, ABC 35, ABCC 7, AHDC, AHO3, AI043036, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, Abacavir hypersensitivity, susceptibility to, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldh, Antigen NY-CO-9, BCD541, BDMR, Beta-interferon, CD142, CD142 antigen, CDA07, CDLS5, CF, CFTR/MRP, CFTR_HUMAN, CPBHM, CTG 26, CTG repeat protein 26, Channel conductance-controlling ATPase, Coagulation factor III, Coagulation factor III (thromboplastin tissue factor), Component of gems 1, Cystic Fibrosis Transmembrane Regulator, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, D10Wsu179e, DKFZP586J0917, DKFZP761B039, DKFZp686H12203, Drug-induced liver injury due to flucloxacillin, EC 3.5.1.98, F3, FLJ16239, FLJ17960, FLJ22237, FLJ35621, FLJ37491, FLJ99588, Fibroblast interferon, GON 10, Gemin-1, HA6116, HD 10, HD 11, HD 2, HD 4, HD 6, HD 7, HD 7B, HD 7a, HD 8, HD 9, HD1, HD3, HD5, HDA10_HUMAN, HDA11_HUMAN, HDAC, HDAC 11, HDAC 7A, HDAC 7B, HDAC 9B, HDAC 9FL, HDAC A, HDAC1_HUMAN, HDAC2_HUMAN, HDAC3_HUMAN, HDAC4_HUMAN, HDAC5_HUMAN, HDAC6_HUMAN, HDAC7_HUMAN, HDAC8_HUMAN, HDAC9_HUMAN, HDACL-1, HDRP, HLA class I histocompatibility antigen, B-13 alpha chain, HLA class I histocompatibility antigen, B-14 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, HLA class I histocompatibility antigen, B-18 alpha chain, HLA class I histocompatibility antigen, B-27 alpha chain, HLA class I histocompatibility antigen, B-35 alpha chain, HLA class I histocompatibility antigen, B-37 alpha chain, HLA class I histocompatibility antigen, B-38 alpha chain, HLA class I histocompatibility antigen, B-40 alpha chain, HLA class I histocompatibility antigen, B-41 alpha chain, HLA class I histocompatibility antigen, B-42 alpha chain, HLA class I histocompatibility antigen, B-44 alpha chain, HLA class I histocompatibility antigen, B-45 alpha chain, HLA class I histocompatibility antigen, B-46 alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-48 alpha chain, HLA class I histocompatibility antigen, B-49 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-51 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain, HLA class I histocompatibility antigen, B-53 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-56 alpha chain, HLA class I histocompatibility antigen, B-57 alpha chain, HLA class I histocompatibility antigen, B-58 alpha chain, HLA class I histocompatibility antigen, B-59 alpha chain, HLA class I histocompatibility antigen, B-67 alpha chain, HLA class I histocompatibility antigen, B-7 alpha chain, HLA class I histocompatibility antigen, B-73 alpha chain, HLA class I histocompatibility antigen, B-78 alpha chain, HLA class I histocompatibility antigen, B-8 alpha chain, HLA class I histocompatibility antigen, B-81 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, Histone Deacetylase A, Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 2 (HD2), Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 4/5 related protein, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 6 (HD6), Histone deacetylase 7, Histone deacetylase 7A, Histone deacetylase 7B, Histone deacetylase 8, Histone deacetylase 9, Histone deacetylase 9A, Histone deacetylase like 1, Histone deacetylase-related protein, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, JM 21, KIAA0017, KIAA0288, KIAA0744, KIAA0901, KIAA1047, Liver mitochondrial ALDH, Lymphocyte antigen, MEF2 interacting transcription repressor protein, MEF2-interacting transcription repressor MITR, MGC149722, MGC1806, MGC2318, MGC96956, MHC class I antigen B 7, MITR, MRXS6, Major Histocompatibility Complex Class I B, Mitochondrial aldehyde dehydrogenase 2, Mono ADP ribosyltransferase sirtuin 6, N Cor/SMRT corepressor Rip13, N-CoR, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-6, NCOR1_HUMAN, NCOR2_HUMAN, NY CO 9, Nuclear Receptor Co-Repressor 2, Nuclear receptor corepressor 1, Nucleus encoded mitochondrial aldehyde dehydrogenase 2, OTTHUMP00000017046, OTTHUMP00000028555, OTTHUMP00000032398, OTTHUMP00000125198, OTTHUMP00000197663, OTTHUMP00000202813, OTTHUMP00000202814, OTTHUMP00000223567, OTTHUMP00000223568, OTTHUMP00000224066, OTTHUMP00000226924, OTTHUMP00000227077, OTTHUMP00000227078, PPP1R90, PUMB 1, Pre-mRNA-splicing factor SF3b 130 kDa subunit, Protein phosphatase 1 regulatory subunit 90, RALDH 1, RIP13, RPD 3, RPD3-2, RPD3L1, RSE1, Reduced potassium dependency yeast homolog like 1, Regulatory protein SIR2 homolog, Regulatory protein SIR2 homolog 2, Regulatory protein SIR2 homolog 6, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, Retinoid X receptor interacting protein 13, Rxrip13, SF3B3_HUMAN, SF3b130, SIR2 like 6, SIR2, S. cerevisiae, homolog-loke 2, SIR2-like protein 2, SIR2-like protein 6, SIR2L, SIR2L2, SIR2L6, SIR6_HUMAN, SIRT 2, SIRT2_HUMAN, SMA, SMA 1, SMA 2, SMA 3, SMA 4, SMAP 270, SMAP45, SMN1, SMN2, SMNT, SMN_HUMAN, SMRT, SMRTE, SMRTE tau, STAF130, Silencing Mediator for Retanoid and Thyroid Hormone Receptors, Silencing information regulator 2 like, Silencing mediator of retinoic acid and thyroid hormone receptor, Silent information regulator 2, Sir2 related protein type 2, Sir2 related protein type 6, Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), Sirtuin 2, Sirtuin 6, Sirtuin type 2, Sirtuin type 6, Spliceosome-associated protein 130, Splicing factor 3B subunit 3, Splicing factor 3b subunit 3 130kD, Survival motor neuron protein, Survival of motor neuron 1, telomeric, Synovitis, chronic, susceptibility to, T-BCD541, T3 receptor-associating factor, TFA, TF_HUMAN, TNR CFTR, TNRC 14, TRAC 1, Thromboplastin, Thyroid retinoic acid receptor associated corepressor, Thyroid-, Tissue factor, WTS, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, cAMP-dependent chloride channel, dJ760C5.1, hN CoR, leukocyte antigen class I-B, retinoic-acid-receptor-associated corepressor, thyroid hormone and retinoic acid receptor associated corepressor 1, transcriptional regulator homolog RPD3

CAS number: 58880-19-6
Purity: > 98%
Form: Solid
Source: Streptomyces sp.
Molecular weight: 302.37 Da
Molecular formula: C₁₇H₂₂N₂O₃
PubChem identifier: 444732
Nature: Native

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Target data

trichostatin A

Key facts

CAS number: 58880-19-6
Purity: > 98%
Form: Solid
Source: Streptomyces sp.
Molecular weight: 302.37 Da
Molecular formula: C₁₇H₂₂N₂O₃
PubChem identifier: 444732
Nature: Native
Biochemical name: trichostatin A
Biological description: Potent, selective histone deacetylase (HDAC) inhibitor (K_i = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.

Also available as a solid (ab120850).
Canonical SMILES: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Isomeric SMILES: C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChI: InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChIKey: RTKIYFITIVXBLE-QEQCGCAPSA-N
IUPAC name: (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Storage

Shipped at conditions: Ambient - Can Ship with Ice
Appropriate long-term storage conditions: -20°C
Storage information: Store under desiccating conditions, The product can be stored for up to 12 months

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