Trichostatin A, histone deacetylase inhibitor
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(5 Publications)
MW 302.37 Da, Purity >98%. Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
View Alternative Names
2810449N18Rik, ABC 35, ABCC 7, AHDC, AHO3, AI043036, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, Abacavir hypersensitivity, susceptibility to, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldh, Antigen NY-CO-9, BCD541, BDMR, Beta-interferon, CD142, CD142 antigen, CDA07, CDLS5, CF, CFTR/MRP, CFTR_HUMAN, CPBHM, CTG 26, CTG repeat protein 26, Channel conductance-controlling ATPase, Coagulation factor III, Coagulation factor III (thromboplastin tissue factor), Component of gems 1, Cystic Fibrosis Transmembrane Regulator, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, D10Wsu179e, DKFZP586J0917, DKFZP761B039, DKFZp686H12203, Drug-induced liver injury due to flucloxacillin, EC 3.5.1.98, F3, FLJ16239, FLJ17960, FLJ22237, FLJ35621, FLJ37491, FLJ99588, Fibroblast interferon, GON 10, Gemin-1, HA6116, HD 10, HD 11, HD 2, HD 4, HD 6, HD 7, HD 7B, HD 7a, HD 8, HD 9, HD1, HD3, HD5, HDA10_HUMAN, HDA11_HUMAN, HDAC, HDAC 11, HDAC 7A, HDAC 7B, HDAC 9B, HDAC 9FL, HDAC A, HDAC1_HUMAN, HDAC2_HUMAN, HDAC3_HUMAN, HDAC4_HUMAN, HDAC5_HUMAN, HDAC6_HUMAN, HDAC7_HUMAN, HDAC8_HUMAN, HDAC9_HUMAN, HDACL-1, HDRP, HLA class I histocompatibility antigen, B-13 alpha chain, HLA class I histocompatibility antigen, B-14 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, HLA class I histocompatibility antigen, B-18 alpha chain, HLA class I histocompatibility antigen, B-27 alpha chain, HLA class I histocompatibility antigen, B-35 alpha chain, HLA class I histocompatibility antigen, B-37 alpha chain, HLA class I histocompatibility antigen, B-38 alpha chain, HLA class I histocompatibility antigen, B-40 alpha chain, HLA class I histocompatibility antigen, B-41 alpha chain, HLA class I histocompatibility antigen, B-42 alpha chain, HLA class I histocompatibility antigen, B-44 alpha chain, HLA class I histocompatibility antigen, B-45 alpha chain, HLA class I histocompatibility antigen, B-46 alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-48 alpha chain, HLA class I histocompatibility antigen, B-49 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-51 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain, HLA class I histocompatibility antigen, B-53 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-56 alpha chain, HLA class I histocompatibility antigen, B-57 alpha chain, HLA class I histocompatibility antigen, B-58 alpha chain, HLA class I histocompatibility antigen, B-59 alpha chain, HLA class I histocompatibility antigen, B-67 alpha chain, HLA class I histocompatibility antigen, B-7 alpha chain, HLA class I histocompatibility antigen, B-73 alpha chain, HLA class I histocompatibility antigen, B-78 alpha chain, HLA class I histocompatibility antigen, B-8 alpha chain, HLA class I histocompatibility antigen, B-81 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, Histone Deacetylase A, Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 2 (HD2), Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 4/5 related protein, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 6 (HD6), Histone deacetylase 7, Histone deacetylase 7A, Histone deacetylase 7B, Histone deacetylase 8, Histone deacetylase 9, Histone deacetylase 9A, Histone deacetylase like 1, Histone deacetylase-related protein, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, JM 21, KIAA0017, KIAA0288, KIAA0744, KIAA0901, KIAA1047, Liver mitochondrial ALDH, Lymphocyte antigen, MEF2 interacting transcription repressor protein, MEF2-interacting transcription repressor MITR, MGC149722, MGC1806, MGC2318, MGC96956, MHC class I antigen B 7, MITR, MRXS6, Major Histocompatibility Complex Class I B, Mitochondrial aldehyde dehydrogenase 2, Mono ADP ribosyltransferase sirtuin 6, N Cor/SMRT corepressor Rip13, N-CoR, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-6, NCOR1_HUMAN, NCOR2_HUMAN, NY CO 9, Nuclear Receptor Co-Repressor 2, Nuclear receptor corepressor 1, Nucleus encoded mitochondrial aldehyde dehydrogenase 2, OTTHUMP00000017046, OTTHUMP00000028555, OTTHUMP00000032398, OTTHUMP00000125198, OTTHUMP00000197663, OTTHUMP00000202813, OTTHUMP00000202814, OTTHUMP00000223567, OTTHUMP00000223568, OTTHUMP00000224066, OTTHUMP00000226924, OTTHUMP00000227077, OTTHUMP00000227078, PPP1R90, PUMB 1, Pre-mRNA-splicing factor SF3b 130 kDa subunit, Protein phosphatase 1 regulatory subunit 90, RALDH 1, RIP13, RPD 3, RPD3-2, RPD3L1, RSE1, Reduced potassium dependency yeast homolog like 1, Regulatory protein SIR2 homolog, Regulatory protein SIR2 homolog 2, Regulatory protein SIR2 homolog 6, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, Retinoid X receptor interacting protein 13, Rxrip13, SF3B3_HUMAN, SF3b130, SIR2 like 6, SIR2, S. cerevisiae, homolog-loke 2, SIR2-like protein 2, SIR2-like protein 6, SIR2L, SIR2L2, SIR2L6, SIR6_HUMAN, SIRT 2, SIRT2_HUMAN, SMA, SMA 1, SMA 2, SMA 3, SMA 4, SMAP 270, SMAP45, SMN1, SMN2, SMNT, SMN_HUMAN, SMRT, SMRTE, SMRTE tau, STAF130, Silencing Mediator for Retanoid and Thyroid Hormone Receptors, Silencing information regulator 2 like, Silencing mediator of retinoic acid and thyroid hormone receptor, Silent information regulator 2, Sir2 related protein type 2, Sir2 related protein type 6, Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), Sirtuin 2, Sirtuin 6, Sirtuin type 2, Sirtuin type 6, Spliceosome-associated protein 130, Splicing factor 3B subunit 3, Splicing factor 3b subunit 3 130kD, Survival motor neuron protein, Survival of motor neuron 1, telomeric, Synovitis, chronic, susceptibility to, T-BCD541, T3 receptor-associating factor, TFA, TF_HUMAN, TNR CFTR, TNRC 14, TRAC 1, Thromboplastin, Thyroid retinoic acid receptor associated corepressor, Thyroid-, Tissue factor, WTS, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, cAMP-dependent chloride channel, dJ760C5.1, hN CoR, leukocyte antigen class I-B, retinoic-acid-receptor-associated corepressor, thyroid hormone and retinoic acid receptor associated corepressor 1, transcriptional regulator homolog RPD3
- Chemical Structure
Lab
Chemical Structure - Trichostatin A, histone deacetylase inhibitor (AB120850)
2D chemical structure image of ab120850, Trichostatin A, histone deacetylase inhibitor
- FuncS
Unknown
Functional Studies - Trichostatin A, histone deacetylase inhibitor (AB120850)
Trichostatin A inhibits histone deacetylases in NIH/3T3 cells. Cells from logarithmic were incubated overnight with different concentrations of Trichostatin A (ab120850). Cell proteins were resolved by SDS-PAGE and probed with anti-acetylated histone antibodies.
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HDACs play important roles in the regulation of gene expression by modifying the acetylation status of histones. They are integral parts of larger protein complexes such as the Sin3 complex or the NuRD complex which mediate interactions with chromatin to repress transcription. Through these complexes HDACs contribute to cell cycle regulation differentiation and apoptosis. The balance between acetylation and deacetylation maintained by HDACs and histone acetyltransferases (HATs) is critical for normal cellular function.
Pathways
These enzymes are essential in signaling and regulatory networks such as the Notch and p53 pathways. HDAC1 for instance interacts with the p53 protein to regulate cell cycle arrest and apoptosis. In the Notch signaling pathway HDACs participate in the regulation of cell fate determination. Their activity in these pathways often involves collaboration with other proteins including co-repressor proteins to exert their biological effects.
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Publications (5)
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Animals : an open access journal from MDPI 15: PubMed40218304
2025
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Anatomy & cell biology 58:247-263 PubMed39809587
2025
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Cell death & disease 13:466 PubMed35585040
2022
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Molecular medicine reports 19:533-540 PubMed30483749
2018
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Learning & memory (Cold Spring Harbor, N.Y.) 23:195-207 PubMed27084927
2016
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