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AB120720

Triptolide from Tripterygium wilfordii, Anti-inflammatory agent

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(2 Publications)

MW 360.41 g/mol, Purity >99%. Active ingredient of the vineTripterygium wilfodii Hook. f. Anti-inflammatory and immunosuppressive agent. Inhibits NF-κB transcriptional activity. Additionally, shows antiproliferative and pro-apoptotic activites. Downregulates RAC1, JAK/STAT 3 pathway and has anticancer properties.
2 Images
Immunocytochemistry/ Immunofluorescence - Triptolide from Tripterygium wilfordii, Anti-inflammatory agent (AB120720)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Triptolide from Tripterygium wilfordii, Anti-inflammatory agent (AB120720)

ab22758 staining nucleolin in HeLa cells treated with Triptolide from Tripterygium wilfordii (ab120720), by ICC/IF. Changes in nuclear localization of nucleolin correlates with increased concentration of Triptolide from Tripterygium wilfordii, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120720 (Triptolide from Tripterygium wilfordii ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab22758 (1 μg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Chemical Structure - Triptolide from Tripterygium wilfordii, Anti-inflammatory agent (AB120720)
  • Chemical Structure

Lab

Chemical Structure - Triptolide from Tripterygium wilfordii, Anti-inflammatory agent (AB120720)

2D chemical structure image of ab120720, Triptolide from Tripterygium wilfordii, Anti-inflammatory agent

Key facts

CAS number

38748-32-2

Purity

>99%

Form

Solid

form

Source

Tripterygium wilfordii

Molecular weight

360.41 g/mol

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>4</sub>O<sub>6</sub>

Nature

Native

Solubility

Soluble in DMSO to 100 mM

Biological description

Active ingredient of the vineTripterygium wilfodii Hook. f. Anti-inflammatory and immunosuppressive agent. Inhibits NF-κB transcriptional activity. Additionally, shows antiproliferative and pro-apoptotic activites. Downregulates RAC1, JAK/STAT 3 pathway and has anticancer properties.

IUPAC Name

(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Genome biology 22:284 PubMed34615539

2021

Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah L Gillen,Chiara Giacomelli,Kelly Hodge,Sara Zanivan,Martin Bushell,Ania Wilczynska

Cell reports 30:81-97.e7 PubMed31914400

2020

DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Zhang,Zhongyang Wu,J Yuyang Lu,Bo Huang,Hongwei Zhou,Wei Xie,Jianlong Wang,Xiaohua Shen
View all publications
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