MW 250.29 g/mol, Purity >98%. Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
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- Protein & cell 8:735-7492017Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeipei Liu et. al.PubMed 28730546
- PloS one 9:e910632014Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTing Wang et. al.PubMed 24608713
Key facts
- CAS number
- 53188-07-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 250.29 g/mol
- Molecular formula
- C14H18O4
- Nature
- Synthetic
Recommended products
MW 250.29 g/mol, Purity >98%. Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
Key facts
- CAS number
- 53188-07-1
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 250.29 g/mol
- Molecular formula
- C14H18O4
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biological description
Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
- IUPAC name
- 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Product promise
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2 product images
Chemical Structure - Trolox, Antioxidant vitamin E derivative (ab120747)
2D chemical structure image of ab120747, Trolox, Antioxidant vitamin E derivative
Image from Wang T, et al. Plos One, 9(3), e91063. Fig 6C and D,; doi: 10.1371/journal.pone.0091063Cellular Activation - Trolox, Antioxidant vitamin E derivative (ab120747)
Endothelial cells were cocultured with Nef-transfected Jurkat cells for 24 h, and then treated with apocynin (200 nM), trolox (200 nM), Nox2 inhibitor (1 µM) or IKKi (100 nM) and incubated an additional 18 h, then analyzed for Nef-induced MCP-1 production (C) and apoptosis of endothelial cells (D). Data were expressed as fold MCP-1 production and apoptosis, normalized to the mean of control measurements.
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