MW 250.29 g/mol, Purity >98%. Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
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- Protein & cell 8:735-7492017Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeipei Liu et. al.PubMed 28730546
- PloS one 9:e910632014Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTing Wang et. al.PubMed 24608713
- Archiv der Pharmazie 345:323-342011Synthesis and antioxidant properties of (3,4-dihydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone and its derivatives.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYasin Cetinkaya,Hülya Göçer,Abdullah Menzek,Ilhami GülçinPubMed 22147548
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 42:843-502004Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTian-Jye Hsieh,Tsan-Zon Liu,Yi-Chen Chia,Chi-Liang Chern,Fung-Jou Lu,Man-chun Chuang,Shin-Yi Mau,Shiang-Hsun Chen,Yu-Hua Syu,Ching-Hsein ChenPubMed 15046831
- The Journal of pharmacy and pharmacology 55:1291-72003Comparative study of eight well-known polyphenolic antioxidants.Applications:Unspecified applicationReactive species:Unspecified reactive speciesP Cos,N Hermans,M Calomme,L Maes,T De Bruyne,L Pieters,A J Vlietinck,D Vanden BerghePubMed 14604473
Key facts
- CAS number
53188-07-1
- Purity
> 98%
- Form
Solid
- Molecular weight
250.29 g/mol
- Molecular formula
C14H18O4
- Nature
Synthetic
Recommended products
MW 250.29 g/mol, Purity >98%. Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
Key facts
- CAS number
53188-07-1
- Purity
> 98%
- Form
Solid
- Molecular weight
250.29 g/mol
- Molecular formula
C14H18O4
- Nature
Synthetic
- Solubility
Soluble in DMSO to 100 mM. Soluble in ethanol to 100 mM.
- Biological description
Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
- IUPAC name
3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
Ambient
- Appropriate long-term storage conditions
Ambient
- Storage information
The product can be stored for up to 12 months
Product promise
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2 product images
Chemical Structure - Trolox, Antioxidant vitamin E derivative (ab120747)
2D chemical structure image of ab120747, Trolox, Antioxidant vitamin E derivative
Image from Wang T, et al. Plos One, 9(3), e91063. Fig 6C and D,; doi: 10.1371/journal.pone.0091063Cellular Activation - Trolox, Antioxidant vitamin E derivative (ab120747)
Endothelial cells were cocultured with Nef-transfected Jurkat cells for 24 h, and then treated with apocynin (200 nM), trolox (200 nM), Nox2 inhibitor (1 µM) or IKKi (100 nM) and incubated an additional 18 h, then analyzed for Nef-induced MCP-1 production (C) and apoptosis of endothelial cells (D). Data were expressed as fold MCP-1 production and apoptosis, normalized to the mean of control measurements.
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