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AB120747

Trolox, Antioxidant vitamin E derivative

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(5 Publications)

MW 250.29 g/mol, Purity >98%. Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.
2 Images
Functional Studies (Act) - Trolox, Antioxidant vitamin E derivative (AB120747)
  • FuncS (Act)

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Functional Studies (Act) - Trolox, Antioxidant vitamin E derivative (AB120747)

Endothelial cells were cocultured with Nef-transfected Jurkat cells for 24 h, and then treated with apocynin (200 nM), trolox (200 nM), Nox2 inhibitor (1 µM) or IKKi (100 nM) and incubated an additional 18 h, then analyzed for Nef-induced MCP-1 production (C) and apoptosis of endothelial cells (D). Data were expressed as fold MCP-1 production and apoptosis, normalized to the mean of control measurements.

Image from Wang T, et al. Plos One, 9(3), e91063. Fig 6C and D,; doi: 10.1371/journal.pone.0091063

Chemical Structure - Trolox, Antioxidant vitamin E derivative (AB120747)
  • Chemical Structure

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Chemical Structure - Trolox, Antioxidant vitamin E derivative (AB120747)

2D chemical structure image of ab120747, Trolox, Antioxidant vitamin E derivative

Key facts

CAS number

53188-07-1

Purity

>98%

Form

Solid

form

Molecular weight

250.29 g/mol

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>8</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biological description

Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.

IUPAC Name

3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product protocols

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Current protocols 5:e70111 PubMed40029168

2025

Imaging the Intestinal Transcriptome With Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH).

Applications

Unspecified application

Species

Unspecified reactive species

Paolo Cadinu,Evan Yang,Rosalind J Xu,Brianna R Watson,Josh Luce,Jeffrey R Moffitt

Cell 187:2010-2028.e30 PubMed38569542

2024

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Paolo Cadinu,Kisha N Sivanathan,Aditya Misra,Rosalind J Xu,Davide Mangani,Evan Yang,Joseph M Rone,Katherine Tooley,Yoon-Chul Kye,Lloyd Bod,Ludwig Geistlinger,Tyrone Lee,Randall T Mertens,Noriaki Ono,Gang Wang,Liliana Sanmarco,Francisco J Quintana,Ana C Anderson,Vijay K Kuchroo,Jeffrey R Moffitt,Roni Nowarski

eLife 12: PubMed37449973

2023

Succinate mediates inflammation-induced adrenocortical dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Ivona Mateska,Anke Witt,Eman Hagag,Anupam Sinha,Canelif Yilmaz,Evangelia Thanou,Na Sun,Ourania Kolliniati,Maria Patschin,Heba Abdelmegeed,Holger Henneicke,Waldemar Kanczkowski,Ben Wielockx,Christos Tsatsanis,Andreas Dahl,Axel Karl Walch,Ka Wan Li,Mirko Peitzsch,Triantafyllos Chavakis,Vasileia Ismini Alexaki

Protein & cell 8:735-749 PubMed28730546

2017

Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.

Applications

Unspecified application

Species

Unspecified reactive species

Peipei Liu,Jinliang Huang,Qian Zheng,Leiming Xie,Xinping Lu,Jie Jin,Geng Wang

PloS one 9:e91063 PubMed24608713

2014

Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Wang,Linden A Green,Samir K Gupta,Chul Kim,Liang Wang,Sharilyn Almodovar,Sonia C Flores,Igor A Prudovsky,Paul Jolicoeur,Ziyue Liu,Matthias Clauss
View all publications

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