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MW 250.29 g/mol, Purity >98%. Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.

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Images

Chemical Structure - Trolox, Antioxidant vitamin E derivative (AB120747), expandable thumbnail
  • Cellular Activation - Trolox, Antioxidant vitamin E derivative (AB120747), expandable thumbnail

Publications

Key facts

CAS number

53188-07-1

Purity

> 98%

Form

Solid

Molecular weight

250.29 g/mol

Molecular formula

C14H18O4

Nature

Synthetic

Recommended products

MW 250.29 g/mol, Purity >98%. Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.

Key facts

Purity

> 98%

Solubility

Soluble in DMSO to 100 mM. Soluble in ethanol to 100 mM.

Biological description

Antioxidant vitamin E derivative. Exhibits lipid peroxidizing, DPPH° scavenging and HO° scavenging activity. Regularly used as an antioxidant standard. Cell-permeable and water soluble.

IUPAC name

3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

Product promise

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2 product images

  • Chemical Structure - Trolox, Antioxidant vitamin E derivative (ab120747), expandable thumbnail

    Chemical Structure - Trolox, Antioxidant vitamin E derivative (ab120747)

    2D chemical structure image of ab120747, Trolox, Antioxidant vitamin E derivative

  • Cellular Activation - Trolox, Antioxidant vitamin E derivative (ab120747), expandable thumbnail
    Image from Wang T, et al. Plos One, 9(3), e91063. Fig 6C and D,; doi: 10.1371/journal.pone.0091063

    Cellular Activation - Trolox, Antioxidant vitamin E derivative (ab120747)

    Endothelial cells were cocultured with Nef-transfected Jurkat cells for 24 h, and then treated with apocynin (200 nM), trolox (200 nM), Nox2 inhibitor (1 µM) or IKKi (100 nM) and incubated an additional 18 h, then analyzed for Nef-induced MCP-1 production (C) and apoptosis of endothelial cells (D). Data were expressed as fold MCP-1 production and apoptosis, normalized to the mean of control measurements.

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Product protocols

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