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AB141043

Tropicamide, M4 antagonist

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MW 284.35 Da, Purity >98%. Potent, selective M4 antagonist (pKi = 7.85). Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

ACM3_HUMAN, ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, ARO, ARO1, Acetylcholine receptor muscarinic 5, Aromatase, CHKM5MR, CHRM 3, CHRM1, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Chrm 4, Chrm 5, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), EGBRS, Estrogen synthase, Estrogen synthetase, HM 3, HM 4, HM 5, HM1, M3 muscarinic receptor, M4, M5R, MGC104309, MGC41838, Microsomal monooxygenase, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, OTTHUMP00000162543, OTTHUMP00000198350, P 450AROM, cholinergic receptor muscarinic 3, flavoprotein-linked monooxygenase, m3 muscarinic acetylcholine receptor, m5, muscarinic 3, muscarinic cholinergic m3 receptor, muscarinic m3 receptor

1 Images
Chemical Structure - Tropicamide, M4 antagonist (AB141043)
  • Chemical Structure

Lab

Chemical Structure - Tropicamide, M4 antagonist (AB141043)

2D chemical structure image of ab141043, Tropicamide, M4 antagonist

Key facts

CAS number

1508-75-4

Purity

>98%

Form

Solid

form

Molecular weight

284.35 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

5593

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 20 mM

Biochemical name

Tropicamide

Biological description

Potent, selective M4 antagonist (pKi = 7.85).

Canonical smiles

CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2

InChi

InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3

InChiKey

BGDKAVGWHJFAGW-UHFFFAOYSA-N

IUPAC Name

N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Muscarinic acetylcholine receptors specifically CHRM1 CHRM3 CHRM4 and CHRM5 are part of the G protein-coupled receptor family. These receptors also known by names such as M1-M5 receptors play critical roles in mediating cholinergic neurotransmission. Molecular weights vary among these receptors but they generally range around 70 kDa. These receptors are highly expressed in central nervous system regions such as cerebral cortex hippocampus and striatum as well as some peripheral tissues. Aromatase another biological target functions as an enzyme that converts androgens to estrogens and is expressed in various tissues including the brain and gonads.
Biological function summary

Muscarinic receptors affect numerous processes by regulating neurotransmitter release and they are integral to modulating synaptic plasticity memory and learning. They do not form part of a complex but interact with various signaling molecules. Aromatase's biological role involves steroid hormone conversion important for maintaining hormonal balances. Its activity leads to estrogen production impacting reproductive and non-reproductive tissues importantly in the maintenance of physiological homeostasis.

Pathways

These receptors participate prominently in cholinergic pathways that influence cognitive and autonomic functions. They interact with signaling proteins like G-proteins and second messengers which mediate neurotransmission and physiological responses. Aromatase fits primarily into steroidogenesis pathways working alongside steroidogenic enzymes to modulate hormone profiles and impact various metabolic and cellular activities.

Muscarinic receptors are implicated in neurological conditions such as Alzheimer’s disease and schizophrenia. Deregulation of these receptors connects to imbalances in neurotransmission and cognitive functions. Aromatase is associated with hormone-dependent cancers like breast cancer given its role in estrogen production. Its activity links to estrogen receptors highlighting its influence on estrogen-responsive tissues in cancer progression and therapy outcomes.
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Product protocols

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