MW 248.24 Da. Indoloquinazoline alkaloid with broad pharmacological activity. Immunomodulatory activity. Blocks BV2 microglia activation in response to LPS. Inhibits pro-inflammatory cytockine production via Nrf2, HO-1 and NFκB pathways. Inhibits indoleamine 2,3-dioxygenase 2 (IC50 = 5-17 μM). Promotes neuronal differentiation of human neuroblastoma cells. Also reported to have anti-cancer, anti-microbial and anti-oxidant activity.
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- Bioorganic & medicinal chemistry 25:4533-45522017Recent synthetic and medicinal perspectives of tryptanthrin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRamandeep Kaur,Sundeep Kaur Manjal,Ravindra K Rawal,Kapil KumarPubMed 28720329
- Frontiers in cellular neuroscience 11:182017Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoung-Won Kwon et. al.PubMed 28210215
- Natural product research 31:2077-20802016In vitro anti-MRSA activity of Couroupita guianensis extract and its component Tryptanthrin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDanielle Cristina Machado Costa,Mariana Maria Barros de Azevedo,Davi Oliveira E Silva,Maria Teresa Villela Romanos,Thais Cristina Baeta Soares Souto-Padrón,Celuta Sales Alviano,Daniela Sales AlvianoPubMed 28013553
- Archives of pharmacal research 36:517-352013Progress in the studies on tryptanthrin, an alkaloid of history.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYurngdong JahngPubMed 23543631
Key facts
- CAS number
13220-57-0
- Form
Solid
- Molecular weight
248.24 Da
- Molecular formula
C15H8N2O2
- PubChem identifier
73549
- Nature
Synthetic
Recommended products
MW 248.24 Da. Indoloquinazoline alkaloid with broad pharmacological activity. Immunomodulatory activity. Blocks BV2 microglia activation in response to LPS. Inhibits pro-inflammatory cytockine production via Nrf2, HO-1 and NFκB pathways. Inhibits indoleamine 2,3-dioxygenase 2 (IC50 = 5-17 μM). Promotes neuronal differentiation of human neuroblastoma cells. Also reported to have anti-cancer, anti-microbial and anti-oxidant activity.
Key facts
- CAS number
13220-57-0
- Form
Solid
- Molecular weight
248.24 Da
- Molecular formula
C15H8N2O2
- PubChem identifier
73549
- Nature
Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
Indolo[2,1-b]quinazoline-6,12-dione
- Biological description
Indoloquinazoline alkaloid with broad pharmacological activity. Immunomodulatory activity. Blocks BV2 microglia activation in response to LPS. Inhibits pro-inflammatory cytockine production via Nrf2, HO-1 and NFκB pathways. Inhibits indoleamine 2,3-dioxygenase 2 (IC50 = 5-17 μM). Promotes neuronal differentiation of human neuroblastoma cells. Also reported to have anti-cancer, anti-microbial and anti-oxidant activity.
- Canonical SMILES
C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2
- InChI
InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H
- InChIKey
VQQVWGVXDIPORV-UHFFFAOYSA-N
- IUPAC name
indolo[2,1-b]quinazoline-6,12-dione
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions
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Chemical Structure - Tryptanthrin, immunomodulator (ab269884)
Chemical structure of Tryptanthrin, immunomodulator, 13220-57-0
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