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AB269884

Tryptanthrin, immunomodulator

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MW 248.24 Da. Indoloquinazoline alkaloid with broad pharmacological activity. Immunomodulatory activity. Blocks BV2 microglia activation in response to LPS. Inhibits pro-inflammatory cytockine production via Nrf2, HO-1 and NFκB pathways. Inhibits indoleamine 2,3-dioxygenase 2 (IC50 = 5-17 μM). Promotes neuronal differentiation of human neuroblastoma cells. Also reported to have anti-cancer, anti-microbial and anti-oxidant activity.
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Chemical Structure - Tryptanthrin, immunomodulator (AB269884)
  • Chemical Structure

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Chemical Structure - Tryptanthrin, immunomodulator (AB269884)

Chemical structure of Tryptanthrin, immunomodulator, 13220-57-0

Key facts

CAS number

13220-57-0

Form

Solid

form

Molecular weight

248.24 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>8</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

73549

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Indolo[2,1-b]quinazoline-6,12-dione

Biological description

Indoloquinazoline alkaloid with broad pharmacological activity. Immunomodulatory activity. Blocks BV2 microglia activation in response to LPS. Inhibits pro-inflammatory cytockine production via Nrf2, HO-1 and NFκB pathways. Inhibits indoleamine 2,3-dioxygenase 2 (IC50 = 5-17 μM). Promotes neuronal differentiation of human neuroblastoma cells. Also reported to have anti-cancer, anti-microbial and anti-oxidant activity.

Canonical smiles

C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2

InChi

InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H

InChiKey

VQQVWGVXDIPORV-UHFFFAOYSA-N

IUPAC Name

indolo[2,1-b]quinazoline-6,12-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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