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MW 222.19 Da, Purity >98%. Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 μM).

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Images

Chemical Structure - TTFA, Mitochondrial Complex II inhibitor (AB223880), expandable thumbnail

Key facts

CAS number
326-91-0
Purity
> 98%
Form
Solid
Molecular weight
222.19 Da
Molecular formula
C8H5F3O2S
PubChem identifier
5601
Nature
Synthetic

Target data

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MW 222.19 Da, Purity >98%. Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 μM).

Key facts

Purity
> 98%
PubChem identifier
5601
Solubility

Soluble in DMSO to 100 mM.

Soluble in ethanol to 100 mM.

Biochemical name
2-Thenoyltrifluoroacetone
Biological description

Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 μM).

Canonical SMILES
C1=CSC(=C1)C(=O)CC(=O)C(F)(F)F
InChI
InChI=1S/C8H5F3O2S/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
InChIKey
TXBBUSUXYMIVOS-UHFFFAOYSA-N
IUPAC name
4,4,4-trifluoro-1-thiophen-2-ylbutane-1,3-dione

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

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1 product image

  • Chemical Structure - TTFA, Mitochondrial Complex II inhibitor (ab223880), expandable thumbnail

    Chemical Structure - TTFA, Mitochondrial Complex II inhibitor (ab223880)

    2D chemical structure image of ab223880, TTFA, Mitochondrial Complex II inhibitor

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Product protocols

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