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AB223880

TTFA, Mitochondrial Complex II inhibitor

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(1 Publication)

MW 222.19 Da, Purity >98%. Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 μM).
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Chemical Structure - TTFA, Mitochondrial Complex II inhibitor (AB223880)
  • Chemical Structure

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Chemical Structure - TTFA, Mitochondrial Complex II inhibitor (AB223880)

2D chemical structure image of ab223880, TTFA, Mitochondrial Complex II inhibitor

Key facts

CAS number

326-91-0

Purity

>98%

Form

Solid

form

Molecular weight

222.19 Da

Molecular formula

C<sub>8</sub>H<sub>5</sub>F<sub>3</sub>O<sub>2</sub>S

PubChem

5601

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

2-Thenoyltrifluoroacetone

Biological description

Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 μM).

Canonical smiles

C1=CSC(=C1)C(=O)CC(=O)C(F)(F)F

InChi

InChI=1S/C8H5F3O2S/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2

InChiKey

TXBBUSUXYMIVOS-UHFFFAOYSA-N

IUPAC Name

4,4,4-trifluoro-1-thiophen-2-ylbutane-1,3-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular systems biology 19:e11267 PubMed37259925

2023

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability.

Applications

Unspecified application

Species

Unspecified reactive species

Amandine Moretton,Savvas Kourtis,Antoni Gañez Zapater,Chiara Calabrò,Maria Lorena Espinar Calvo,Frédéric Fontaine,Evangelia Darai,Etna Abad Cortel,Samuel Block,Laura Pascual-Reguant,Natalia Pardo-Lorente,Ritobrata Ghose,Matthew G Vander Heiden,Ana Janic,André C Müller,Joanna I Loizou,Sara Sdelci
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