MW 364.4 Da, Purity >=98%. Potent GPR120 (free fatty acid receptor 4; FFAR4) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3).
BMIQ10, FFA1R, FFAR1_HUMAN, Free fatty acid receptor 1, Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor 40, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, GPCR40, GPR 120, GPR 129, GPR 40, GT01, HGNC:19345, MGC119984, O3FA1_HUMAN, O3FAR1, Omega-3 fatty acid receptor 1, PGR 4
MW 364.4 Da, Purity >=98%. Potent GPR120 (free fatty acid receptor 4; FFAR4) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3).
DMSO (~20 mg/ml).
Potent GPR120 (free fatty acid receptor 4; FFAR4) agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4.19 for FFA1; displays no activity at FFA2 or FFA3).
This product is manufactured by BioVision, an Abcam company and was previously called B2285 TUG-891. B2285-5 is the same size as the 5 mg size of ab286985.
GPR120 and GPR40 also known as FFAR4 and FFAR1 respectively are G-protein-coupled receptors (GPCRs) involved in sensing free fatty acids. GPR120 has a molecular mass of approximately 42.6 kDa while GPR40 has a mass of about 34.8 kDa. These receptors are widely expressed in tissues such as the intestine liver and adipose tissue. GPR120 tends to be present in immune cells and hypothalamic neurons reflecting its role in lipid metabolism and inflammation. On the other hand GPR40 is largely found in pancreatic beta cells which suggests its connection to insulin regulation.
GPR120 and GPR40 function as nutrient sensors engaging in the regulation of energy balance and glucose homeostasis. GPR120 operates by binding to various polyunsaturated fatty acids and influences the release of hormones like GLP-1 which regulates appetite and insulin sensitivity. GPR40 primarily engages with medium- and long-chain free fatty acids facilitating insulin secretion. Neither GPR120 nor GPR40 forms part of a larger protein complex functioning independently to transmit signals via G-protein pathways.
GPR120 and GPR40 are integrated into metabolic pathways associated with glucose and lipid metabolism. GPR120 activation triggers downstream signaling pathways such as PI3K and MAPK vital for inflammation control and insulin sensitivity. GPR40 through binding to its ligands affects the phosphatidylinositol pathway which is essential for glucose-stimulated insulin release. Both receptors show interaction with key proteins in these pathways like AKT and ERK1/2 emphasizing their roles in maintaining metabolic balance.
Research connects GPR120 and GPR40 to metabolic conditions specifically type 2 diabetes and obesity. GPR120 exhibits potential anti-inflammatory effects that are beneficial in obesity management aligning with reduced risk for insulin resistance. GPR40 links to type 2 diabetes through its role in enhancing insulin secretion a critical function compromised in the disease. Problems with these receptors can also involve proteins such as IRS1 and PPARs which are important in the development and progression of these metabolic disorders.
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