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AB141557

Tyrphostin 25 (RG-50875), Competitive EGF receptor tyrosine kinase inhibitor

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MW 202.17 Da, Purity >99%. Cell-permeable and competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 μM). Effects platelet-derived growth factor (PDGF) and insulin receptor tyrosine kinases. Active in vivo.

View Alternative Names

Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, DINB protein, DINB1, DINP, DNA damage inducible protein b, DNA polymerase kappa, DinB homolog 1 (E. coli), EGFR_HUMAN, ERBB, ERBB1, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Errp, HER1, NISBD2, Oncogen ERBB, PIG61, POLK_HUMAN, POLQ, Polymerase (DNA directed) kappa, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase ErbB-1, SA7, Species antigen 7, Urogastrone, Wa5, erb-b2 receptor tyrosine kinase 1, mENA, polymerase, DNA, kappa, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2

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Chemical Structure - Tyrphostin 25 (RG-50875), Competitive EGF receptor tyrosine kinase inhibitor (AB141557)
  • Chemical Structure

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Chemical Structure - Tyrphostin 25 (RG-50875), Competitive EGF receptor tyrosine kinase inhibitor (AB141557)

2D chemical structure image of ab141557, Tyrphostin 25 (RG-50875), Competitive EGF receptor tyrosine kinase inhibitor

Key facts

CAS number

118409-58-8

Purity

>99%

Form

Solid

form

Molecular weight

202.17 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>6</sub>N<sub>2</sub>O<sub>3</sub>

PubChem

2061

Nature

Synthetic

Solubility

Soluble in ethanol

Soluble in DMSO

Biochemical name

Tyrphostin A25

Biological description

Cell-permeable and competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 μM). Effects platelet-derived growth factor (PDGF) and insulin receptor tyrosine kinases. Active in vivo.

Canonical smiles

C1=C(C=C(C(=C1O)O)O)C=C(C#N)C#N

InChi

InChI=1S/C10H6N2O3/c11-4-7(5-12)1-6-2-8(13)10(15)9(14)3-6/h1-3,13-15H

InChiKey

YZOFLYUAQDJWKV-UHFFFAOYSA-N

IUPAC Name

2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target EGFR also known as Epidermal Growth Factor Receptor is a transmembrane protein that plays a critical role in cell signaling pathways involved in cell growth and differentiation. It belongs to a family of membrane-bound receptor tyrosine kinases. EGFR has a molecular mass of approximately 170 kDa and is expressed in various epithelial tissues including the lung liver and pancreas. DNA Polymerase Kappa also referred to as POLK is a specialized DNA polymerase involved in DNA repair with a molecular mass of approximately 98 kDa and it is frequently expressed in the nucleus of multiple cell types.
Biological function summary

EGFR functions by binding to ligands like epidermal growth factor (EGF) leading to its autophosphorylation and the activation of downstream signaling. It participates in several cellular processes such as proliferation migration and survival. EGFR often forms a complex with other HER family receptors influencing the dynamic regulation of signaling processes. In contrast POLK participates in error-prone DNA repair mechanisms allowing the bypass of DNA lesions during replication and it does not typically form such complexes.

Pathways

EGFR is an important player in the MAPK and PI3K/AKT pathways which are important for transmitting extracellular signals that affect cellular responses. It interacts closely with proteins like Ras MEK and Akt within these pathways amplifying diverse cellular responses. On the other hand POLK integrates into the DNA damage tolerance pathway involving proteins such as PCNA and RAD18 which facilitate its role in translesion synthesis during DNA replication.

Aberrant EGFR signaling links to various cancers including non-small cell lung cancer and colorectal cancer. Mutations and overexpression of EGFR can activate oncogenic pathways often in conjunction with proteins like KRAS and BRAF promoting tumorigenesis. POLK's role in inaccurate DNA repair associates with genomic instability which can lead to conditions like cancer. Its interactions with DNA repair proteins including RAD18 can influence the propensity for mutations that drive cancer development.
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Product protocols

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