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MW 353.35 Da, Purity >98%. GluK1 (formerly GluR5) and GluK3 (formerly GluR7) receptor selective antagonist (Kb =10 nM and IC50 = 23 nM, respectively). IC50 values are >100 μM at recombinant human GLUA2 (formerly GluR2), GluK2 (formerly GluR6,) GluK2/GluK5 (formerly GluR6/KA2) and GluK2/GluK3 (formerly GluR6/GluR7). Selective over native AMPA receptors (Kd = 83 μM) and exhibits no activity at NMDA and Group I mGlu receptors at concentrations of up to 10 μM.
Alternative names=AMPA 1, AMPA-selective glutamate receptor 1, EEA3, Excitatory amino acid receptor 3, Excitatory amino acid receptor 5, GLR 7, GLR5, GLUH1, GRIA1_HUMAN, GRIK1_HUMAN, GRIK3_HUMAN, GluA1, GluR 7a, GluR-1, GluR-5, GluR-6, GluR-7, GluR-A, GluR-K1, Glutamate receptor, Glutamate receptor 1, Glutamate receptor 5, Glutamate receptor 7, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic kainate 1, Glutamate receptor ionotropic kainate 3, HBGR1, Human glutamate receptor GLUR5, MGC133252, OTTHUMP00000096569, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, ionotropic kainate 1, ionotropic kainate 3
- CAS number
902464-46-4
- Purity
> 98%
- Form
Solid
- Molecular weight
353.35 Da
- Molecular formula
C14H15N3O6S
- PubChem identifier
6420160
- Nature
Synthetic
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MW 353.35 Da, Purity >98%. GluK1 (formerly GluR5) and GluK3 (formerly GluR7) receptor selective antagonist (Kb =10 nM and IC50 = 23 nM, respectively). IC50 values are >100 μM at recombinant human GLUA2 (formerly GluR2), GluK2 (formerly GluR6,) GluK2/GluK5 (formerly GluR6/KA2) and GluK2/GluK3 (formerly GluR6/GluR7). Selective over native AMPA receptors (Kd = 83 μM) and exhibits no activity at NMDA and Group I mGlu receptors at concentrations of up to 10 μM.
Alternative names=AMPA 1, AMPA-selective glutamate receptor 1, EEA3, Excitatory amino acid receptor 3, Excitatory amino acid receptor 5, GLR 7, GLR5, GLUH1, GRIA1_HUMAN, GRIK1_HUMAN, GRIK3_HUMAN, GluA1, GluR 7a, GluR-1, GluR-5, GluR-6, GluR-7, GluR-A, GluR-K1, Glutamate receptor, Glutamate receptor 1, Glutamate receptor 5, Glutamate receptor 7, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic kainate 1, Glutamate receptor ionotropic kainate 3, HBGR1, Human glutamate receptor GLUR5, MGC133252, OTTHUMP00000096569, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, ionotropic kainate 1, ionotropic kainate 3
Key facts
- CAS number
902464-46-4
- Purity
> 98%
- Form
Solid
- Molecular weight
353.35 Da
- Molecular formula
C14H15N3O6S
- PubChem identifier
6420160
- Nature
Synthetic
- Biochemical name
(S)-1-(2-Amino-2-carboxyethyl)-3(2-carboxythiophene-3-YL-methyl)-5-methylpyrimidine-2,4-dione
- Biological description
GluK1 (formerly GluR5) and GluK3 (formerly GluR7) receptor selective antagonist (Kb =10 nM and IC50 = 23 nM, respectively). IC50 values are >100 μM at recombinant human GLUA2 (formerly GluR2), GluK2 (formerly GluR6,) GluK2/GluK5 (formerly GluR6/KA2) and GluK2/GluK3 (formerly GluR6/GluR7). Selective over native AMPA receptors (Kd = 83 μM) and exhibits no activity at NMDA and Group I mGlu receptors at concentrations of up to 10 μM.
- Canonical SMILES
CC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)CC(C(=O)O)N
- Isomeric SMILES
CC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N
- InChI
InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
- InChIKey
ZTAZUCRXCRXNSU-VIFPVBQESA-N
- IUPAC name
3-[[3-[(2S)-2-amino-2-carboxyethyl]-5-methyl-2,6-dioxopyrimidin-1-yl]methyl]thiophene-2-carboxylic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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